Development and validation of a UPLC–MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice

2016 ◽  
Vol 122 ◽  
pp. 148-156 ◽  
Author(s):  
Satish I. Rao ◽  
Michael Pugh ◽  
Melissa Nelson ◽  
Joseph A. Reddy ◽  
Patrick J. Klein ◽  
...  
Keyword(s):  
Small Molecule ◽  
The Novel ◽  
Drug Conjugate ◽  
Small Molecule Drug ◽  
Development And Validation

scholarly journals Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134

2014 ◽  
Vol 8 (5) ◽  
pp. 956-967 ◽  
Author(s):  
Yassar M. Hashim ◽  
Dirk Spitzer ◽  
Suwanna Vangveravong ◽  
Mary C. Hornick ◽  
Gunjal Garg ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Small Molecule ◽  
Drug Conjugate ◽  
Small Molecule Drug ◽  
Pancreatic Cancer Therapy

Phase 1 study of the PSMA-targeted tubulysin small-molecule drug conjugate EC1169 in patients with metastatic castrate-resistant prostate cancer (mCRPC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 2586-2586
Author(s):  
Michael J. Morris ◽  
Daniel Peter Petrylak ◽  
A. Oliver Sartor ◽  
Nicholas J. Vogelzang ◽  
Michael Groaning ◽  
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Keyword(s):  
Prostate Cancer ◽  
Small Molecule ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Drug Conjugate ◽  
Small Molecule Drug ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant

scholarly journals A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2170-2174 ◽  
Author(s):  
Andrew Michael Beekman ◽  
Marco M. D. Cominetti ◽  
Oliver Charles Cartwright ◽  
Dale L. Boger ◽  
Mark Searcey
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Small Molecule ◽  
Solid Phase ◽  
Cancer Cell Lines ◽  
Drug Conjugate ◽  
Small Molecule Drug

A SMDC is delivered to GCPII, an important cancer target. The payload is released by enzymes overexpressed in cancer cell lines. The SMDC relies on GCPII expression for efficacy.

Enhancing the Pharmacokinetics and Antitumor Activity of an α-Amanitin-Based Small-Molecule Drug Conjugate via Conjugation with an Fc Domain

2021 ◽  
Vol 64 (7) ◽  
pp. 4117-4129
Author(s):  
Francesca Gallo ◽  
Barbara Korsak ◽  
Christoph Müller ◽  
Torsten Hechler ◽  
Desislava Yanakieva ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Small Molecule ◽  
Drug Conjugate ◽  
Small Molecule Drug
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