Sample preparation composite and replicate strategy case studies for assay of solid oral drug products

2017 ◽  
Vol 146 ◽  
pp. 59-67 ◽  
Author(s):  
Beverly Nickerson ◽  
Brent Harrington ◽  
Fasheng Li ◽  
Michele Xuemei Guo
Keyword(s):  
Sample Preparation ◽  
Case Studies ◽  
Oral Drug ◽  
Drug Products

Sample Preparation Composite and Replicate Strategy for Assay of Solid Oral Drug Products

2014 ◽  
Vol 86 (24) ◽  
pp. 11930-11936 ◽  
Author(s):  
Brent Harrington ◽  
Beverly Nickerson ◽  
Michele Xuemei Guo ◽  
Marc Barber ◽  
David Giamalva ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Oral Drug ◽  
Drug Products

Development of a sample preparation method for accurate analysis of 24 elemental impurities in oral drug products by ICP-MS according to USP/ICH guidelines

2021 ◽  
Author(s):  
Xiao Gu ◽  
Siqi Zhu ◽  
Linqi Yan ◽  
Lei Cheng ◽  
Peixi Zhu ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Preparation Method ◽  
Oral Drug ◽  
Sample Preparation Method ◽  
Accurate Analysis ◽  
Drug Products ◽  
Elemental Impurities ◽  
Ich Guidelines ◽  
Icp Ms ◽  
Preparation Strategy

A novel sample preparation strategy was developed for accurate analysis of all 24 USP/ICH target elements in oral drug products.

Impacts of Sample Preparation Methodology on TEM Failure Analysis of Advanced Semiconductor Devices

2011 ◽  
Author(s):  
Yongkai Zhou ◽  
Jie Zhu ◽  
Han Wei Teo ◽  
ACT Quah ◽  
Lei Zhu ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Failure Analysis ◽  
Case Studies ◽  
Thickness Measurement ◽  
Interface Roughness ◽  
Silicide Formation ◽  
Cross Sectional ◽  
Inspection Method ◽  
Low Mass

Abstract In this paper, two failure analysis case studies are presented to demonstrate the importance of sample preparation procedures to successful failure analyses. Case study 1 establishes that Palladium (Pd) cannot be used as pre-FIB coating for SiO2 thickness measurement due to the spontaneously Pd silicide formation at the SiO2/Si interface. Platinum (Pt) is thus recommended, in spite of the Pt/SiO2 interface roughness, as the pre-FIB coating in this application. In the second case study, the dual-directional TEM inspection method is applied to characterize the profile of the “invisible” tungsten residue defect. The tungsten residue appears invisible in the planeview specimen due to the low mass-thickness contrast. It is then revealed in the cross-sectional TEM inspection.

Report from the “3rd International Symposium on BA/BE of Oral Drug Products: Biopharmaceutics meets Galenics”

2020 ◽  
Vol 56 ◽  
pp. 101274
Author(s):  
P. Paixão ◽  
K. Kawakami ◽  
M. Bermejo ◽  
Y. Tsume ◽  
N. Silva ◽  
...  
Keyword(s):  
International Symposium ◽  
Oral Drug ◽  
Drug Products

ChemInform Abstract: Package Selection for Moisture Protection for Solid, Oral Drug Products

ChemInform ◽  
2011 ◽  
Vol 42 (6) ◽  
pp. no-no
Author(s):  
Kenneth C. Waterman ◽  
Bruce C. MacDonald
Keyword(s):  
Oral Drug ◽  
Drug Products ◽  
Moisture Protection ◽  
Selection For

scholarly journals Successful sample preparation for serial crystallography experiments

2019 ◽  
Vol 52 (6) ◽  
pp. 1385-1396 ◽  
Author(s):  
John H. Beale ◽  
Rachel Bolton ◽  
Stephen A. Marshall ◽  
Emma V. Beale ◽  
Stephen B. Carr ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Case Studies ◽  
Free Electron Laser ◽  
Laser Light ◽  
Light Sources ◽  
Batch Crystallization ◽  
X Ray ◽  
Vapour Diffusion ◽  
Serial Crystallography ◽  
The Many

Serial crystallography, at both synchrotron and X-ray free-electron laser light sources, is becoming increasingly popular. However, the tools in the majority of crystallization laboratories are focused on producing large single crystals by vapour diffusion that fit the cryo-cooled paradigm of modern synchrotron crystallography. This paper presents several case studies and some ideas and strategies on how to perform the conversion from a single crystal grown by vapour diffusion to the many thousands of micro-crystals required for modern serial crystallography grown by batch crystallization. These case studies aim to show (i) how vapour diffusion conditions can be converted into batch by optimizing the length of time crystals take to appear; (ii) how an understanding of the crystallization phase diagram can act as a guide when designing batch crystallization protocols; and (iii) an accessible methodology when attempting to scale batch conditions to larger volumes. These methods are needed to minimize the sample preparation gap between standard rotation crystallography and dedicated serial laboratories, ultimately making serial crystallography more accessible to all crystallographers.

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