Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC–MS: A potential agent for promoting tumor-targeted drug delivery

A simple and versatile nanoformulation strategy is presented by combining the synthetic lipids, biocompatible polymer, and tumor penetrating peptide (LyP-1) into a composite nanosystem for targeted drug delivery and imaging in a single session.

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Ingenious pH-sensitive etoposide loaded folic acid decorated mesoporous silica-carbon dot with carboxymethyl-βcyclodextrin gatekeeper for targeted drug delivery and imaging

Materials Science and Engineering C ◽

10.1016/j.msec.2018.07.043 ◽

2018 ◽

Vol 92 ◽

pp. 892-901 ◽

Cited By ~ 10

Author(s):

Marziyeh Poshteh Shirani ◽

Behzad Rezaei ◽

Taghi Khayamian ◽

Mohammad Dinari ◽

Fazileh Hosseini Shamili ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Mesoporous Silica ◽

Targeted Drug Delivery ◽

Ph Sensitive ◽

Carbon Dot ◽

Targeted Drug

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Development and characterization of surface engineered PPI dendrimers for targeted drug delivery

Artificial Cells Nanomedicine and Biotechnology ◽

10.3109/21691401.2016.1160912 ◽

2016 ◽

Vol 45 (3) ◽

pp. 414-425 ◽

Cited By ~ 18

Author(s):

Avleen Kaur ◽

Keerti Jain ◽

Neelesh Kumar Mehra ◽

N. K. Jain

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Targeted Drug

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pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method

ACS Applied Materials & Interfaces ◽

10.1021/am4018237 ◽

2013 ◽

Vol 5 (18) ◽

pp. 8939-8947 ◽

Cited By ~ 29

Author(s):

Abdallah Laouini ◽

Konstantinos P. Koutroumanis ◽

Catherine Charcosset ◽

Stella Georgiadou ◽

Hatem Fessi ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Ph Sensitive ◽

Membrane Contactor ◽

Targeted Drug

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Development of Chitosan-Based pH-Sensitive Polymeric Micelles Containing Curcumin for Colon-Targeted Drug Delivery

AAPS PharmSciTech ◽

10.1208/s12249-017-0906-y ◽

2017 ◽

Vol 19 (3) ◽

pp. 991-1000 ◽

Cited By ~ 19

Author(s):

Thisirak Woraphatphadung ◽

Warayuth Sajomsang ◽

Theerasak Rojanarata ◽

Tanasait Ngawhirunpat ◽

Prasopchai Tonglairoum ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Polymeric Micelles ◽

Ph Sensitive ◽

Targeted Drug

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pH-Sensitive Nanomedicine for Treating Gynaecological Cancers

Journal of Woman s Reproductive Health ◽

10.14302/issn.2381-862x.jwrh-19-3143 ◽

2020 ◽

Vol 2 (2) ◽

pp. 35-50

Author(s):

Pramod Vishwanath Prasad ◽

Kakali Purkayastha ◽

Utkarsh Sharma ◽

Mayadhar Barik

Keyword(s):

Drug Delivery ◽

Anticancer Agents ◽

Targeted Drug Delivery ◽

Drug Carrier ◽

Therapeutic Index ◽

Ph Sensitive ◽

Stimuli Responsive ◽

Specific Distribution ◽

Targeted Drug ◽

Host Tissues

Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine.Nonetheless, theside-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive nanocarrier system, particularly pH-sensitive nanosystems offer an attractive strategy. Targeted drug delivery through pH-sensitive nanosystems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumor cells and/or by decreasing the exposure in normal host tissues. Therefore, nanoscale-based drug delivery through pH-sensitive nanosystems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.

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