Ingenious pH-sensitive etoposide loaded folic acid decorated mesoporous silica-carbon dot with carboxymethyl-βcyclodextrin gatekeeper for targeted drug delivery and imaging

pH-Sensitive quercetin/Fe3O4 NPs loaded functionalized mesoporous SBA-15 fabricated for targeted drug delivery to colorectal carcinoma cells with high anti-carcinogenic efficacy.

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Redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles: a folic acid mediated biocompatible cancer-targeted drug delivery system

Journal of Materials Chemistry B ◽

10.1039/c4tb01030b ◽

2014 ◽

Vol 2 (40) ◽

pp. 7009-7016 ◽

Cited By ~ 20

Author(s):

Srivardhan Reddy Gayam ◽

Shu-Pao Wu

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

System P ◽

Redox Responsive ◽

Targeted Drug ◽

Targeted Drug Delivery System

Herein, redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles were designed for an effective cancer-targeted drug delivering system.

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Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery

Advanced Healthcare Materials ◽

10.1002/adhm.201200176 ◽

2012 ◽

Vol 2 (2) ◽

pp. 281-286 ◽

Cited By ~ 98

Author(s):

Fabiola Porta ◽

Gerda E. M. Lamers ◽

Jess Morrhayim ◽

Antonia Chatzopoulou ◽

Marcel Schaaf ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Targeted Drug

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Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery

Journal of Inclusion Phenomena and Macrocyclic Chemistry ◽

10.1007/s10847-017-0741-5 ◽

2017 ◽

Vol 89 (1-2) ◽

pp. 15-27 ◽

Cited By ~ 1

Author(s):

Pervin Deveci ◽

Bilge Taner ◽

Safaa Hashım Mohammed Albayatı

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Targeted Drug Delivery ◽

Ph Sensitive ◽

Targeted Drug

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Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽

10.3390/polym13010059 ◽

2020 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Abeer M. Beagan ◽

Ahlam A. Alghamdi ◽

Shatha S. Lahmadi ◽

Majed A. Halwani ◽

Mohammed S. Almeataq ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Folic Acid ◽

Drug Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Ethyl Methacrylate ◽

Mesoporous Nanoparticles ◽

Targeted Drug ◽

Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽

10.3390/cancers13133321 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3321

Author(s):

Etienne J. Slapak ◽

Lily Kong ◽

Mouad el Mandili ◽

Rienk Nieuwland ◽

Alexander Kros ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Conditioned Medium ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Pdac Cell ◽

Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

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