scholarly journals Quantification of the Relative Contribution of Environmental and Genetic Factors to Variation in Cystic Fibrosis Lung Function

2010 ◽  
Vol 157 (5) ◽  
pp. 802-807.e3 ◽  
Author(s):  
J. Michael Collaco ◽  
Scott M. Blackman ◽  
John McGready ◽  
Kathleen M. Naughton ◽  
Garry R. Cutting
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Genetic Factors ◽  
Cystic Fibrosis Lung ◽  
Relative Contribution

scholarly journals Correction: Pyrosequencing Unveils Cystic Fibrosis Lung Microbiome Differences Associated with a Severe Lung Function Decline

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160726 ◽  
Author(s):  
Giovanni Bacci ◽  
Patrizia Paganin ◽  
Loredana Lopez ◽  
Chiara Vanni ◽  
Claudia Dalmastri ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Cystic Fibrosis Lung ◽  
Lung Function Decline ◽  
Lung Microbiome ◽  
Severe Lung

scholarly journals Pyrosequencing Unveils Cystic Fibrosis Lung Microbiome Differences Associated with a Severe Lung Function Decline

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156807 ◽  
Author(s):  
Giovanni Bacci ◽  
Patrizia Paganin ◽  
Loredana Lopez ◽  
Chiara Vanni ◽  
Claudia Dalmastri ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Cystic Fibrosis Lung ◽  
Lung Function Decline ◽  
Lung Microbiome ◽  
Severe Lung

Rapid lung function decline in adults with early-stage cystic fibrosis lung disease

2020 ◽  
Vol 19 (4) ◽  
pp. 527-533
Author(s):  
Elliott C. Dasenbrook ◽  
Aliza K. Fink ◽  
Michael S. Schechter ◽  
Don B. Sanders ◽  
Stefanie J. Millar ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Lung Disease ◽  
Early Stage ◽  
Cystic Fibrosis Lung ◽  
Lung Function Decline ◽  
Cystic Fibrosis Lung Disease

scholarly journals Immediate effects of lumacaftor/ivacaftor administration on lung function in patients with severe cystic fibrosis lung disease

2017 ◽  
Vol 16 (3) ◽  
pp. 392-394 ◽  
Author(s):  
Natalia Popowicz ◽  
Jamie Wood ◽  
Anna Tai ◽  
Sue Morey ◽  
Siobhain Mulrennan
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Cystic Fibrosis Lung Disease

scholarly journals CXCR4+ granulocytes reflect fungal cystic fibrosis lung disease

2015 ◽  
Vol 46 (2) ◽  
pp. 395-404 ◽  
Author(s):  
Melanie Carevic ◽  
Anurag Singh ◽  
Nikolaus Rieber ◽  
Olaf Eickmeier ◽  
Matthias Griese ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Lung Disease ◽  
Immune Cells ◽  
Therapeutic Target ◽  
Cystic Fibrosis Lung ◽  
Fungal Colonisation ◽  
Cystic Fibrosis Lung Disease ◽  
Potential Biomarker ◽  
Healthy Control

Cystic fibrosis airways are frequently colonised with fungi. However, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.We characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic fibrosis disease controls and healthy control subjects cross-sectionally and longitudinally and correlated these findings with lung function parameters.Cystic fibrosis patients with chronic fungal colonisation by Aspergillus fumigatus were characterised by an accumulation of a distinct granulocyte subset, expressing the HIV coreceptor CXCR4. Percentages of airway CXCR4+ granulocytes correlated with lung disease severity in patients with cystic fibrosis.These studies demonstrate that chronic fungal colonisation with A. fumigatus in cystic fibrosis patients is associated with CXCR4+ airway granulocytes, which may serve as a potential biomarker and therapeutic target in fungal cystic fibrosis lung disease.

scholarly journals Rapid cystic fibrosis lung-function decline and in-vitro CFTR modulation

2021 ◽  
Author(s):  
Emrah Gecili ◽  
Weiji Su ◽  
Cole Brokamp ◽  
Eleni-Rosalina Andrinopoulou ◽  
Francis J. LaRosa III ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Cystic Fibrosis Lung ◽  
Lung Function Decline
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