Influence of Ultraviolet Radiation on the Association between 25-Hydroxy Vitamin D Levels and Cardiovascular Risk Factors in Obesity

Aim. To assess vitamin D level in patients with acute coronary syndrome and to determine the relationships of vitamin D level with specific patterns of cardiovascular disease in this group of patients.Methods. 50 patients (35 (70%) males and 15 (30%) females) urgently admitted to the emergency cardiology department of Kaliningrad Regional Hospital were enrolled in the cross-sectional observational study. Patients with diabetes mellitus, autoimmune diseases and cancer were excluded from the study. The mean age of patients was 60 (55; 66) years. Cardiovascular risk factors (obesity, smoking, physical activity, alcohol consumption, genetic predisposition) were assessed in all patients. Total serum cholesterol levels, GFR (CKD-EPI) and troponin levels were measured in all participants. Echocardiography included the measurement of the left ventricular mass index. Coronary angiography with omnipaque contrast was performed in all cases. 25-OH vitamin D was measured with enzyme-linked immunosorbent assay (ELISA).Results. The majority of patients with acute coronary syndrome had vitamin D deficiency. 3 (6%) patients had severe vitamin D deficiency. The subgroup of patients with marked vitamin D deficiency (n = 39) more often had elevated blood pressure probably related to the left ventricular hypertrophy and left atrial enlargement. Left ventricular systolic dysfunction and occlusive coronary artery disease were more common in patients with lower vitamin D levels. Statistically significant correlations had not been found between vitamin D levels and cardiovascular risk factors as well as laboratory data.Conclusion. Vitamin D level below normal range was detected in the vast majority of patients with acute coronary syndrome, of them 6 % of patients had critically low vitamin D levels.

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Hypovitaminosis D is associated with sleep disorders in workers on alternating shifts with cardiovascular risk factors

10.1101/2021.05.04.21256625 ◽

2021 ◽

Author(s):

Luiz Antonio Alves Menezes Junior ◽

Virginia Capistrano Fajardo ◽

Silvia Nascimento Nascimento de Freitas ◽

Fausto Aloisio Pedrosa Pimenta ◽

Fernando Luiz Luiz Pereira Pereira de Oliveira ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Sleep Disturbances ◽

Hypovitaminosis D ◽

Arterial Oxygen ◽

Shift Workers ◽

Vitamin D Levels ◽

Sleep Parameters

Shift work has serious health impacts due to desynchronization of the circadian rhythm; consequently, the workers have increased sleep disturbances. Another impact is working hours, which can contribute to decreased sun exposure and lead to the development of hypovitaminosis D. Vitamin D has been implicated in extraskeletal functions in many physiological mechanisms, including sleep. Therefore, we aimed to verify the association between sleep parameters and hypovitaminosis D in shift workers with cardiovascular risk. We conducted a cross-sectional study of 82 male rotating shift workers (24-57 years old) with at least one cardiovascular risk factor (such as hyperglycemia, dyslipidemia, abdominal obesity, physical inactivity, hypertension, and smoking). Polysomnography was used to evaluate sleep parameters, while vitamin D levels were measured using a chemiluminescence method. Logistic regression was used to model the association between hypovitaminosis D and sleep parameters after adjustment for relevant covariates. Hypovitaminosis D (< 20 ng/mL) was seen in 30.5% of the workers. Shift workers with hypovitaminosis D had lower sleep efficiency, increased microarousal index, and lower arterial oxygen saturation after adjusting for seasonality, age, and body fat. Therefore, we suggest that hypovitaminosis D is associated with greater sleep disturbances in rotating shift workers with cardiovascular risk factors.

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