Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

Sacrococcygeal teratomas (SCT) are tumors that arise in the sacrococcygeal area containing tissuefrom all three germ layers. SCT has an incidence of approximately one in 35,000 – 40,000 live birthswith malignant transformation with increasing age. We report a case in a four year old which was excisedcompletely via the postanal route with no operative or postoperative morbidity. The histopathology wasthat of yolk sac variant and she is planned for chemoradiotherapy.Key words: Childhood tumors; Sacrum; Sacrococcygeal teratomaDOI: 10.3126/jnps.v30i2.3450J. Nepal Paediatr. Soc. May-August, 2010 Vol 30(2) 113-115

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Early Detection of Malignant Transformation After Neonatal Sacrococcygeal Teratoma

Pediatric Hematology and Oncology ◽

10.3109/08880018709141266 ◽

1987 ◽

Vol 4 (2) ◽

pp. 171-172 ◽

Cited By ~ 3

Author(s):

Markku Heikinheimo ◽

Jukka Rajantie ◽

Pentti Kuusela ◽

Martti A. Siimes

Keyword(s):

Early Detection ◽

Malignant Transformation ◽

Sacrococcygeal Teratoma

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Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1415 ◽

2017 ◽

Vol 8 (2) ◽

pp. 73-76 ◽

Cited By ~ 1

Author(s):

Ruchika Garg ◽

Arvind V Shetti ◽

Anjana S Bagewadi

Keyword(s):

Oral Cancer ◽

Comparative Study ◽

Malignant Transformation ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Oral Leukoplakia ◽

Control Group ◽

Significant Difference ◽

Potentially Malignant ◽

Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

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Recurrent Retrorectal Teratoma

Case Reports in Medicine ◽

10.1155/2014/491605 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3

Author(s):

P. Geoff Vana ◽

Sherri Yong ◽

Dana Hayden ◽

Theodore Saclarides ◽

Michelle Slogoff ◽

...

Keyword(s):

Lower Extremity ◽

Young Woman ◽

Malignant Transformation ◽

Surgical Resection ◽

Cystic Mass ◽

Sacrococcygeal Teratoma ◽

Retrorectal Tumors ◽

Sacrococcygeal Region ◽

Rare Group

Retrorectal tumors are a rare group of neoplasms that occur most commonly in the neonatal and infant population. They vary in presentation, but teratomas are the most common and often present as a protruding mass from the sacrococcygeal region. Immediate surgical resection is indicated when found and coccygectomy is performed to prevent recurrence. When teratomas recur, the patients most often have vague symptoms and the tumors usually have malignant transformation. Here, we present the case of a young woman who underwent surgical resection of a sacrococcygeal teratoma at 3 days of age where the coccyx was not removed. She presented at 31 years of age with lower extremity paresthesias and radiography revealed a cystic mass extending from the sacrum. After resection, pathology revealed a recurrent teratoma with nests of adenocarcinoma.

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Variants of Currarino Syndrome: Embryological Association and Review of Pertinent Literature

International Journal of Embryology ◽

10.1155/2014/636375 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Rahul Gupta ◽

Shyam Bihari Sharma ◽

Praveen Mathur ◽

Ram Babu Goyal

Keyword(s):

Sacrococcygeal Teratoma ◽

Presacral Mass ◽

Wound Sepsis ◽

Causative Gene ◽

Currarino Syndrome ◽

Cloacal Malformation ◽

First Case ◽

Sacral Defect ◽

Malformation Complex ◽

Sigmoid Loop Colostomy

Currarino syndrome is a triad of sacral defect, anorectal malformation and a presacral mass. The diagnosis is usually made late in childhood and about 50% of cases are familial with autosomal dominant inheritance. We present two neonates (one with vestibular fistula, and another with cloacal malformation) with the features consistent with Currarino syndrome, but with Altman’s type II sacrococcygeal teratoma, that is, presacral mass having an external sacrococcygeal component also. We believe that this triad should be considered a variant of Currarino syndrome. In first case, excision of the mass along with coccyx, followed by primary Posterior Sagittal AnoRectoPlasty was performed in the same setting. The patient succumbed to death due to septicemia as a result of wound sepsis. Learning from the previous experience, we decided to do a diverting sigmoid loop colostomy followed by posterior sagittal excision of the mass along with coccyx, in same sitting in the second case. There was no recurrence. Though HLXB9 has been identified as the major causative gene in Currarino syndrome, exact pathogenesis is still unclear. We herein highlight the significance of this variant of Currarino syndrome and propose a theory on the basis of an embryological association between the malformation complex.

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