Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

2017 ◽  
Vol 8 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Ruchika Garg ◽  
Arvind V Shetti ◽  
Anjana S Bagewadi
Keyword(s):  
Oral Cancer ◽  
Comparative Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Control Group ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

scholarly journals Cytomorphometric analysis of exfoliated cells in oral lichen planus

CytoJournal ◽  
2014 ◽  
Vol 11 ◽  
pp. 3 ◽  
Author(s):  
Chitturi Suryaprakash Ravi Teja ◽  
A. Santha Devy ◽  
R. Madhavan Nirmal ◽  
P. M. Sunil ◽  
M. Deepasree
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Exfoliative Cytology ◽  
Normal Tissues ◽  
Exfoliated Cells ◽  
Healthy Mucosa ◽  
Significant Difference ◽  
Malignant Changes ◽  
Oral Lichen

Background: Tumors are distinguished from normal tissues partly by their pronounced variability of cellular and nuclear dimensions. Therefore, such factors may be an indicator to assess whether the cells are malignant or not. Exfoliative cytology is a reliable tool in assessing such changes in the uterine cervix and has been used in the oral cavity also with success. The aims and objectives of the following study were to evaluate the malignant changes by assessing the quantitative parameters such as cytoplasmic diameter, cytoplasmic perimeter and cytoplasmic area (CD, CP, CA) and nuclear diameter, nuclear perimeter and nuclear area (ND, NP, NA) and cytoplasmic to nuclear ratio in the exfoliated cells of various subtypes of oral lichen planus (OLP) using cytomorphometry. Materials and Methods: Oral exfoliated cells from nineteen cases of histologically proven OLP (1 atrophic, 13 reticular, 4 erosive and 1 plaque) and ten controls with healthy mucosa were taken and stained by Feulgen-Rossenback reaction and cytomorphometric analysis was performed using an image analysis software. The parameters taken into account were CD, CP, CA and ND, NP, NA. Furthermore CA/NA was calculated. The parameters were statistically analyzed using the t-test. Results: Cytomorphometric analysis of all the parameters showed no significant difference between the control group and the reticular/plaque subtypes, whereas statistically significant (P < 0.05) differences was obtained between the control group and the atrophic/erosive subtypes group when compared using t-test. Conclusions: The cytomorphometric analysis of OLP shows that erosive/atrophic subtypes of OLP are at more risk and exfoliative cytology and cytomorphometry can be used as a tool to assess the malignant changes.

scholarly journals Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. Methods We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. Results The study population included 123 men and 442 women aged 21–93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

scholarly journals Malignant Transformation of Oral Lichen Planus: A Retrospective Study of 565 Japanese Patients

2021 ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Clear Differentiation ◽  
Oral Lichen

Abstract Objective Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear.Materials and Methods We designed this study to examine the demographic and clinical characteristics of OLP and evaluate its malignant potential. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions (OLCLs), oral lichenoid drug reactions (OLDRs) and oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) were excluded.Results The study population included 123 men and 442 women aged 21-93 years (median, 62 years). The 565 patients were followed up for an average duration of 55.9 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type.Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.Clinical relevance We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia (OED) and OLLs to enable early detection of malignant transformation.

scholarly journals Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fahimeh Rezazadeh ◽  
Sara Haghighat
Keyword(s):  
Immune System ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Serum Levels ◽  
Control Group ◽  
Related Disorder ◽  
Significant Difference ◽  
The Difference ◽  
Southwest Of Iran ◽  
Oral Lichen

Introduction. Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. Methods and Materials. 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C). Results. Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57 . Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant. Conclusion. Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran.

scholarly journals The Assessment of Angiogenesis by Microvessel Density in Patients With Atrophic/Erosive or Reticular Oral Lichen Planus

2021 ◽  
Author(s):  
Maryam Mardani ◽  
Azadeh Andisheh-Tadbir ◽  
Mahya Haghparast
Keyword(s):  
Lichen Planus ◽  
Microvessel Density ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Disease ◽  
Staining Procedure ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
Oral Lichen

The role of angiogenesis in the development of chronic inflammatory diseases, including oral lichen planus (OLP), is of great concern. The most representative method for the assessment of angiogenesis is the semi-quantification of microvessel density (MVD) using specific markers such as CD105. We aimed to assess the MVD in patients with OLP and find its clinical significance to differentiate the atrophic/erosive forms from reticular ones. This cross-sectional study was conducted on 82 patients with clinically and histopathologically proven cases of OLP, including reticular (n=52) or atrophic/erosive (n=30) lesions. The control group comprised 82 age- and sex-matched subjects without any oral disease. To assess the MVD using CD105, tissue blocks were sliced, and the immunoexpression of CD105 was measured by the standard immunohistochemical staining procedure. The mean value of MVD in OLP patients was significantly higher than that in the controls (14.61±12.48 vs. 8.67±1.76, P<0.0001). Furthermore, there was a significant difference in the mean MVD value between reticular and atrophic/erosive lesions (8.19±7.13 vs. 25.73±12.06, P=0.001). However, no significant difference was observed between the reticular lesions and normal tissues (P=0.58). An increased level of CD105 in OLP patients can improve our knowledge about the causes and mechanisms of the disease. The CD105-MVD assessment might be a useful method for semiquantitative measurement of angiogenesis in OLP patients as well as differentiating its clinical forms; therefore, it can open new vistas for formulating strategies based on antiangiogenic treatments for the management of OLP and other precancerous lesions.

scholarly journals Comparative study of biochemical alterations in oral lichen planus patients in comparison with a control group

2016 ◽  
pp. S1-1
Author(s):  
A Yanez Busto ◽  
F Suarez Alen ◽  
M Penamaria Mallon ◽  
G Arias Lopez ◽  
E Otero Rey ◽  
...  
Keyword(s):  
Comparative Study ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Biochemical Alterations ◽  
Oral Lichen

scholarly journals Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study

2018 ◽  
Vol 19 (12) ◽  
pp. 3635-3641 ◽  
Author(s):  
Karandeep Singh Arora ◽  
Rahul Bansal ◽  
Shreeyam Mohapatra ◽  
Akshay Verma ◽  
Sakshi Sharma ◽  
...  
Keyword(s):  
Observational Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Oral Lichen

scholarly journals Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5740
Author(s):  
Paolo G. Arduino ◽  
Alessandro Magliano ◽  
Alessio Gambino ◽  
Alessandra Macciotta ◽  
Mario Carbone ◽  
...  
Keyword(s):  
Cohort Study ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Northern Italy ◽  
Elderly Subjects ◽  
Histopathological Diagnosis ◽  
Oral Lichen

Background: Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP. Methods: A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period. Results: The study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death. Conclusion: This is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.

scholarly journals High-level laser therapy versus scalpel surgery in the treatment of oral lichen planus: a randomized control trial

2021 ◽  
Author(s):  
Svetlana Tarasenko ◽  
Mikhail Stepanov ◽  
Elena Morozova ◽  
Alexey Unkovskiy
Keyword(s):  
Surgical Treatment ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Pain Level ◽  
Level Laser ◽  
Significant Difference ◽  
High Level ◽  
Oral Lichen ◽  
Level Reduction

Abstract Objective To compare the clinical effectiveness of various types of high-level laser therapy (HLLT) toward scalpel excision for the surgical treatment of erosive oral lichen planus (OLP). Materials and methods The total number of 128 individuals were enrolled in the study. The 35 did not meet the inclusion criteria due to malignancy signs and presence of diabetes mellitus. In total, 8 were lost to follow-up, and 10 were excluded from the analysis, due to analgesics intake. This way 75 patients with the erosive form of OLP were analyzed in three intervention groups (Er:YAG, n = 19; Nd:YAG, n = 15; Er:YAG + Nd:YAG combination, n = 20) and one control group with scalpel excision (n = 21). The therapy effectiveness has been assessed based on the comparison of salivary interleukin (IL)-1β, IL-6 and interferon (IFN)-γ preoperative levels to 14, 30 days, and 2 years postoperation, as well as pain level and time of epithelization. Results All HLLT groups demonstrated a significantly (p > 0.05) higher IL-1β, IL-6, IFNγ and pain level reduction and quicker epithelization toward the control group on the 30th day, except Nd:YAG in case of IFNγ level. The highest IL-1β, IFNγ and pain level reduction and quicker epithelization on the 30th day was observed in Er:YAG group, followed by Er:YAG + Nd:YAG combination, Nd:YAG respectively. However no significant difference was observed between the HLLT groups with regard to IL-6 level reduction. After a 2-year follow-up, no significant difference was observed between all study groups with regard to all variables. Conclusion HLLT yields a superior clinical outcome compared to the scalpel excision for the surgical treatment of oral lichen planus, whereby the Er:YAG has been proposed as the most effective laser type at the end of the first postoperative month. Clinical relevance For the surgical treatment of erosive OLP the Er:YAG laser may be a preferable treatment option compared to Nd:YAG and scalpel surgery. Trial registration The present trial was registered retrospectively in the German Clinical Trials Register, as a member of WHO international clinical trials registry platform, on the 18.03.2020 with the following number: DRKS00020986

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