Enhancement of cutaneous immune response to bacterial infection after low-level light therapy with 1072nm infrared light: A preliminary study

2011 ◽  
Vol 105 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Seung Yoon Celine Lee ◽  
In-Wha Seong ◽  
Ji-Seon Kim ◽  
Kyeong-A. Cheon ◽  
Se Hun Gu ◽  
...  
Keyword(s):  
Immune Response ◽  
Bacterial Infection ◽  
Light Therapy ◽  
Infrared Light ◽  
Low Level Light Therapy ◽  
Low Level ◽  
Preliminary Study

Photobiomodulation: The Clinical Applications of Low-Level Light Therapy

2021 ◽  
Author(s):  
Graeme Ewan Glass
Keyword(s):  
Near Infrared ◽  
Clinical Evidence ◽  
Acne Vulgaris ◽  
Body Contouring ◽  
Light Therapy ◽  
Infrared Light ◽  
Skin Rejuvenation ◽  
Near Infrared Light ◽  
Low Level Light Therapy ◽  
Low Level

Abstract Background Low level light therapy is a recent aaddition to the pantheon of light-based therapeutic interventions. Termed “photobiomodulation”, the absorption of red/near infrared light energy induces enhancement of mitochondrial ATP production, cell signaling and growth factor synthesis and attenuates oxidative stress. Photobiomodulation is highly commercialized with devices marketed directly to the consumer. In the grey area between the commercial and therapeutic sectors, harnessing the clinical potential in reproducible and scientifically measurable ways remains challenging. Objectives This article presents a summary of the clinical evidence for photobiomodulation and discusses the regulatory framework for low level light therapy Methods A review of the clinical literature pertaining to the use of low level light therapy for skin rejuvenation (facial rhytids and dyschromias), acne vulgaris, wound healing, body contouring and androgenic alopecia was performed. Results A reasonable body of clinical trial evidence exists in support of the role of low energy red/near infrared light as a safe and effective method of skin rejuvenation, treatment of acne vulgaris, alopecia and, especially, body contouring. Methodological flaws, small patient cohorts and industry funding mean there is ample scope to improve the quality of evidence. It remains unclear if LED-based light sources induces physiologic effects of the nature and magnitude of laser-based systems which were used in most of the higher quality studies. Conclusions Low level light therapy is here to stay. However, its ubiquity and commercial success has outpaced the empirical approach on which solid clinical evidence is established. Thus, the challenge is to prove its therapeutic utility in retrospect. Well-designed, adequately powered, independent clinical trials will help us answer some of the unresolved questions and enable the potential of this therapy to be realized.

Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device–Controlled Multicenter Trial

2013 ◽  
Vol 39 (8) ◽  
pp. 1177-1183 ◽  
Author(s):  
Hyojin Kim ◽  
Jee Woong Choi ◽  
Jun Young Kim ◽  
Jung Won Shin ◽  
Seok-jong Lee ◽  
...  
Keyword(s):  
Light Therapy ◽  
Multicenter Trial ◽  
Androgenetic Alopecia ◽  
Double Blind ◽  
Low Level Light Therapy ◽  
Low Level

Angiogenic Synergistic Effect of Adipose-Derived Stromal Cell Spheroids with Low-Level Light Therapy in a Model of Acute Skin Flap Ischemia

2016 ◽  
Vol 202 (5-6) ◽  
pp. 307-318 ◽  
Author(s):  
In-Su Park ◽  
Phil-Sang Chung ◽  
Jin Chul Ahn
Keyword(s):  
Growth Factors ◽  
Skin Flap ◽  
Light Therapy ◽  
Skin Flaps ◽  
Low Level Light Therapy ◽  
Low Level ◽  
Cell Source ◽  
Hematoxylin And Eosin ◽  
Recipient Tissue ◽  
Regeneration Of Skin

Human adipose-derived mesenchymal stem cells (hASCs) are an attractive cell source for tissue engineering. However, one obstacle to this approach is that the transplanted hASC population can decline rapidly in the recipient tissue. The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted spheroid hASCs in skin flaps of mice. hASCs were cultured in monolayers or spheroids. LLLT, hASCs, spheroids and spheroids transplanted with LLLT were applied to the skin flaps. Healing of the skin flaps was assessed by gross evaluation and by hematoxylin and eosin staining and elastin van Gieson staining. Compared with the spheroid group, skin flap healing was enhanced in the spheroid + LLLT group, including the neovascularization and regeneration of skin appendages. The survival of hASCs was enhanced by decreased apoptosis of hASCs in the skin flaps of the spheroid + LLLT group. The secretion of growth factors was stimulated in the spheroid + LLLT group compared with the ASC and spheroid groups. These data suggest that LLLT was an effective biostimulator of spheroid hASCs in the skin flaps, enhancing the survival of hASCs and stimulating the secretion of growth factors.

195. Phenotype restoration of trophoblasts in preeclampsia by Low Level Light Therapy (LLLT)

2018 ◽  
Vol 13 ◽  
pp. S95-S96
Author(s):  
Dorothee Weihrauch ◽  
Janine Struve ◽  
Alina Brener ◽  
Natalie Mcvey ◽  
Rhett Nances ◽  
...  
Keyword(s):  
Light Therapy ◽  
Low Level Light Therapy ◽  
Low Level
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