Differential Expression of Endothelial Nitric Oxide Synthase in Coronary and Cardiac Tissue in Hypoxic Fetal Guinea Pig Hearts

2006 ◽  
Vol 13 (7) ◽  
pp. 483-490 ◽  
Author(s):  
Yafeng Dong ◽  
Loren P. Thompson
2005 ◽  
Vol 1047 (1) ◽  
pp. 85-96 ◽  
Author(s):  
Ulf-Rüdiger Heinrich ◽  
Oxana Selivanova ◽  
Ralph Feltens ◽  
Jürgen Brieger ◽  
Wolf Mann

2001 ◽  
Vol 76 (3) ◽  
pp. S57-S58
Author(s):  
M.R Freeman ◽  
A Archibong ◽  
G.A Hill ◽  
G.A Weitzman ◽  
C.M Whitworth ◽  
...  

Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).


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