scholarly journals Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement

2021 ◽  
Author(s):  
Nourhan A. Abdulla ◽  
Gehan F. Balata ◽  
Hanaa A. El-ghamry ◽  
Eman Gomaa
Keyword(s):  
Intranasal Delivery ◽  
Bioavailability Enhancement

scholarly journals Intranasal delivery of a bivalent norovirus vaccine formulated in an in situ gelling dry powder

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177310 ◽  
Author(s):  
Jordan P. Ball ◽  
Michael J. Springer ◽  
Yawei Ni ◽  
Isaac Finger-Baker ◽  
Juan Martinez ◽  
...  
Keyword(s):  
Intranasal Delivery ◽  
Dry Powder ◽  
In Situ Gelling

In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA

2001 ◽  
Vol 59 (1) ◽  
pp. 144-151 ◽  
Author(s):  
Jeong-Sook Park ◽  
Yu-Kyoung Oh ◽  
Ho Yoon ◽  
Jung Mogg Kim ◽  
Chong-Kook Kim
Keyword(s):  
Plasmid Dna ◽  
Intranasal Delivery ◽  
Mucoadhesive Polymer ◽  
In Situ Gelling

scholarly journals Intranasal Delivery of Immunotherapeutic Nanoformulations for Treatment of Glioma Through in situ Activation of Immune Response

2020 ◽  
Vol Volume 15 ◽  
pp. 1499-1515 ◽  
Author(s):  
Peidi Yin ◽  
Huifeng Li ◽  
Chao Ke ◽  
Guangxu Cao ◽  
Xiaoqian Xin ◽  
...  
Keyword(s):  
Immune Response ◽  
Intranasal Delivery ◽  
In Situ Activation

scholarly journals Intranasal Delivery of Immunotherapeutic Nanoformulations for Treatment of Glioma Through in situ Activation of Immune Response [Corrigendum]

2020 ◽  
Vol Volume 15 ◽  
pp. 8873-8874
Author(s):  
Peidi Yin ◽  
Huifeng Li ◽  
Chao Ke ◽  
Guangxu Cao ◽  
Xiaoqian Xin ◽  
...  
Keyword(s):  
Immune Response ◽  
Intranasal Delivery ◽  
In Situ Activation

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel

2017 ◽  
Vol 97 ◽  
pp. 30-37 ◽  
Author(s):  
Joana Sousa ◽  
Gilberto Alves ◽  
Paula Oliveira ◽  
Ana Fortuna ◽  
Amílcar Falcão
Keyword(s):  
Intranasal Delivery ◽  
In Situ Gel

scholarly journals Development of a Cyclodextrin-Based Mucoadhesive-Thermosensitive In Situ Gel for Clonazepam Intranasal Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 969
Author(s):  
Marzia Cirri ◽  
Francesca Maestrelli ◽  
Giulia Nerli ◽  
Natascia Mennini ◽  
Mario D’Ambrosio ◽  
...  
Keyword(s):  
Drug Release ◽  
Gelation Time ◽  
Sodium Hyaluronate ◽  
Controlled Drug Release ◽  
Intranasal Delivery ◽  
Gelation Temperature ◽  
In Situ Gel ◽  
Permeation Studies ◽  
The One

A thermosensitive, mucoadhesive in-situ gel for clonazepam (CLZ) intranasal delivery was developed, which aimed to achieve prolonged in-situ residence and controlled drug release, overcoming problems associated with its oral or parenteral administration. Poloxamer was selected as a thermosensitive polymer and chitosan glutamate and sodium hyaluronate as mucoadhesive and permeation enhancer. Moreover, randomly methylated β-Cyclodextrin (RAMEB) was used to improve the low drug solubility. A screening DoE was applied for a systematic examination of the effect of varying the formulation components proportions on gelation temperature, gelation time and pH. Drug-loaded gels at different clonazepam-RAMEB concentrations were then prepared and characterized for gelation temperature, gelation time, gel strength, mucoadhesive strength, mucoadhesion time, and drug release properties. All formulations showed suitable gelation temperature (29–30.5 °C) and time (50–65 s), but the one with the highest drug-RAMEB concentration showed the best mucoadhesive strength, longest mucoadhesion time (6 h), and greatest release rate. Therefore, it was selected for cytotoxicity and permeation studies through Caco-2 cells, compared with an analogous formulation without RAMEB and a drug solution. Both gels were significantly more effective than the solution. However, RAMEB was essential not only to promote drug release, but also to reduce drug cytotoxicity and further improve its permeability.

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