Alvimopan combined with enhanced recovery strategy for managing postoperative ileus after open abdominal surgery: a systematic review and meta-analysis

2016 ◽  
Vol 203 (1) ◽  
pp. 211-221 ◽  
Author(s):  
Liang-Liang Xu ◽  
Xiao-Qin Zhou ◽  
Peng-Sheng Yi ◽  
Ming Zhang ◽  
Jing Li ◽  
...  
2016 ◽  
Vol 40 (10) ◽  
pp. 2319-2330 ◽  
Author(s):  
Julia B. Kössler-Ebs ◽  
Kathrin Grummich ◽  
Katrin Jensen ◽  
Felix J. Hüttner ◽  
Beat Müller-Stich ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121187 ◽  
Author(s):  
André L. Mihaljevic ◽  
Tara C. Müller ◽  
Victoria Kehl ◽  
Helmut Friess ◽  
Jörg Kleeff

2020 ◽  
Vol 102 (3) ◽  
pp. 194-203
Author(s):  
MJ Lee ◽  
P Vaughan-Shaw ◽  
D Vimalachandran ◽  

Introduction Postoperative ileus occurs frequently following abdominal surgery. Identification of groups at high risk of developing ileus before surgery may allow targeted interventions. This review aimed to identify baseline risk factors for ileus. Methods A systematic review was conducted with reference to PRISMA and MOOSE guidelines. It was registered on PROSPERO (CRD42017068697). Searches of MEDLINE, EMBASE and CENTRAL were undertaken. Studies reporting baseline risk factors for the development of postoperative ileus based on cohort or trial data and published in English were eligible for inclusion. Dual screening of abstracts and full texts was undertaken. Independent dual extraction was performed. Bias assessment was undertaken using the quality in prognostic studies tool. Meta-analysis using a random effects model was undertaken where two or more studies assessed the same variable. Findings Searches identified 2,430 papers, of which 28 were included in qualitative analysis and 12 in quantitative analysis. Definitions and incidence of ileus varied between studies. No consistent significant effect was found for association between prior abdominal surgery, age, body mass index, medical comorbidities or smoking status. Male sex was associated with ileus on meta-analysis (odds ratio 1.12, 95% confidence interval 1.02–1.23), although this may reflect unmeasured factors. The literature shows inconsistent effects of baseline factors on the development of postoperative ileus. A large cohort study using consistent definitions of ileus and factors should be undertaken.


2017 ◽  
Vol 45 (06) ◽  
pp. 1127-1145 ◽  
Author(s):  
Yunhong Liu ◽  
Winnie P. Y. Tang ◽  
Shengxiang Gong ◽  
Carmen W. H. Chan

Postoperative ileus is a common and often life-threatening gastrointestinal complication with few management methods available for patients. Integrating acupressure into perioperative care promises to bring benefits into preventing postoperative ileus. This systematic review and meta-analysis aims to evaluate the efficacy of acupressure in identifying the signs and symptoms of postoperative ileus among patients undergoing abdominal surgery. The MEDLINE, EMBASE, Web of Science, CINAHL, China Journal Net and Wanfang databases were searched for high-quality RCTs using keywords such as acupressure, postoperative ileus, abdominal surgery, etc. A total of six studies ([Formula: see text]) were included in this review and meta-analysis. The quality of the literature was found to be uniformly moderate by the Effective Public Health Practice Project (EPHPP) assessment tool. The results of meta-analyses revealed that acupressure could significantly reduce risks for postoperative nausea (OR 0.52, 95% CI 0.39–0.70, [Formula: see text]) and vomiting (OR 0.54, 95% CI 0.39–0.75, [Formula: see text]) compared with the control group, without significant heterogeneity among studies. Meta-analysis of the need for antiemetic drugs suggested that the OR was 0.39 (95% CI 0.20–0.78, [Formula: see text]) with significant heterogeneity among studies. Our results suggested that acupressure might be effective in reducing the incidence of postoperative nausea and vomiting and the need for antiemetic drugs among patients undergoing abdominal surgery. Considering the substantial risk of bias in the articles included, future high-quality RCTs with a rigorous methodology are desirable to provide solid evidence. Furthermore, other signs and symptoms of postoperative ileus should be explored in future.


2021 ◽  
Author(s):  
Jun Watanabe ◽  
Atsushi Miki ◽  
Kazuhiko Kotani ◽  
Naohiro Sata

Introduction: Coffee, a popular and cheap beverage worldwide, may have an important effect on postoperative ileus (POI). However, previous systematic reviews have not clarified whether the effect is due to caffeine or coffee itself, or shortening hospital stay. We will aim to assess the effect of postoperative coffee consumption on POI. Methods: Studies evaluating the effect of postoperative coffee consumption will be searched using the electronic databases and the trial registries. Meta-analyses will be performed using random-effects models. The Grading of Recommendations, Assessment, Development, and Evaluation approach will be used to assess the certainty of evidence.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jean F. Hamel ◽  
Charles Sabbagh ◽  
Arnaud Alves ◽  
Jean M. Regimbeau ◽  
Timothée Vignaud ◽  
...  

AbstractDespite a significant improvement with enhanced recovery programmes (ERP), gastro-intestinal (GI) functions that are impaired after colorectal resection and postoperative ileus (POI) remain a significant issue. In the literature, there is little evidence of the distinction between the treatment assessed within or outside ERP. The purpose was to evaluate the efficiency of treatments to reduce POI and improve GI function recovery within ERP. A search was performed in PubMed and Scopus on 20 September 2019. The studies were included if they compared the effect of the administration of a treatment aiming to treat or prevent POI or improve the early functional outcomes of colorectal surgery within an ERP. The main outcome measures were the occurrence of postoperative ileus, time to first flatus and time to first bowel movement. Treatments that were assessed at least three times were included in a meta-analysis. Among the analysed studies, 28 met the eligibility criteria. Six of them focused on chewing-gum and were only randomized controlled trials (RCT) and 8 of them focused on Alvimopan but none of them were RCT. The other measures were assessed in less than 3 studies over RCTs (n = 11) or retrospective studies (n = 2). In the meta-analysis, chewing gum had no significant effect on the endpoints and Alvimopan allowed a significant reduction of the occurrence of POI. Chewing-gum was not effective on GI function recovery in ERP but Alvimopan and the other measures were not sufficiently studies to draw conclusion. Randomised controlled trials are needed.Systematic review registration number CRD42020167339.


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