Clinical Characteristics and Natural History of Quasi-Moyamoya Disease

Object. The purpose of this study was to delineate the long-term natural history of hemorrhagic moyamoya disease (MMD).Methods. A retrospective review was conducted among 42 patients suffering from hemorrhagic MMD who had been treated conservatively without bypass surgery. The group included four patients who had undergone indirect bypass surgery after an episode of rebleeding. The follow-up period averaged 80.6 months. The clinical features of the first bleeding episode and repeated bleeding episodes were analyzed to determine the risk factors of rebleeding and poor outcome.Intraventricular hemorrhage with or without intracerebral hemorrhage was a dominant finding on computerized tomography scans during the first bleeding episode in 29 cases (69%). During the follow-up period, 14 patients experienced a second episode of bleeding, which occurred 10 years or longer after the original hemorrhage in five cases (35.7%). The annual rebleeding rate was 7.09%/person/year. The second bleeding episode was characterized by a change in which hemisphere bleeding occurred in three cases (21.4%) and by the type of bleeding in seven cases (50%). After rebleeding the rate of good recovery fell from 45.5% to 21.4% and the mortality rate rose from 6.8% to 28.6%. Rebleeding and patient age were statistically significant risk factors of poor outcome. All four patients in whom there was indirect revascularization after the second bleeding episode experienced a repeated bleeding episode within 8 years.Conclusions. The occurrence of rebleeding a long time after the first hemorrhagic episode was not uncommon. Furthermore, the change in which hemisphere and the type of bleeding that occurred after the first episode suggested the difficulty encountered in the prevention of repeated hemorrhage.

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Multicenter registry of CRPC patients: Clinical characteristics and natural history of the disease

European Urology Supplements ◽

10.1016/s1569-9056(18)33765-5 ◽

2018 ◽

Vol 17 (14) ◽

pp. e2905-e2906

Author(s):

V.J. Valencia Guadalajara ◽

L. Martinez Cayuelas ◽

P. Sarrio Sanz ◽

L. Sanchez Caballero ◽

J.J. Pacheco Bru ◽

...

Keyword(s):

Natural History ◽

Clinical Characteristics ◽

History Of ◽

Multicenter Registry

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Clinical Characteristics and Natural History of Autoimmune Forms of Interstitial Lung Disease: A Single-Center Experience

Lung ◽

10.1007/s00408-019-00276-7 ◽

2019 ◽

Vol 197 (6) ◽

pp. 709-713

Author(s):

Sandra Chartrand ◽

Joyce S. Lee ◽

Jeffrey J. Swigris ◽

Lina Stanchev ◽

Aryeh Fischer

Keyword(s):

Interstitial Lung Disease ◽

Natural History ◽

Lung Disease ◽

Clinical Characteristics ◽

Single Center ◽

Single Center Experience ◽

History Of

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Comparative clinical characteristics and natural history of three variants of sclerosing cholangitis: IgG4-related SC, PSC/AIH and PSC alone

Autoimmunity Reviews ◽

10.1016/j.autrev.2017.05.018 ◽

2017 ◽

Vol 16 (8) ◽

pp. 875-882 ◽

Cited By ~ 9

Author(s):

Min Lian ◽

Bo Li ◽

Xiao Xiao ◽

Yue Yang ◽

Pan Jiang ◽

...

Keyword(s):

Natural History ◽

Sclerosing Cholangitis ◽

Clinical Characteristics ◽

History Of

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Epidemiology, clinical characteristics and natural history of vertically transmitted human immunodeficiency virus-1 infection in Japan

Pediatrics International ◽

10.1111/j.1442-200x.1998.tb01979.x ◽

1998 ◽

Vol 40 (5) ◽

pp. 496-502

Author(s):

Kunihiko Akagi

Keyword(s):

Human Immunodeficiency Virus ◽

Natural History ◽

Clinical Characteristics ◽

Immunodeficiency Virus ◽

History Of ◽

Human Immunodeficiency Virus 1

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The Neurosyphilitic Psychoses Today

The British Journal of Psychiatry ◽

10.1192/bjp.115.518.31 ◽

1969 ◽

Vol 115 (518) ◽

pp. 31-38 ◽

Cited By ~ 49

Author(s):

Kenneth Dewhurst

Keyword(s):

Natural History ◽

Clinical Picture ◽

Mental Hospital ◽

Clinical Characteristics ◽

Psychotic Illness ◽

Mental Hospitals ◽

Complete Ignorance ◽

History Of

Neurosyphilis, causing a psychotic illness of such severity as to necessitate admission to a mental hospital, though now rare, has not been completely eradicated. This study is based on 91 psychotic patients with neurosyphilis admitted to six mental hospitals between 1950 and 1965. Its main purpose is to ascertain the incidence, and to present the natural history of the neurosyphilitic psychoses during a period when antibiotics were available. It is likely that some patients in this series were given penicillin for an intercurrent infection in complete ignorance of the underlying syphilitic process. Indeed, Joffe, Black and Floyd (1968) and Heathfield (1968) have reported modifications in the clinical picture of neurosyphilis, tending to mask the diagnosis, caused by earlier administration of antibiotics for intercurrent infections. Thus the widespread use of antibiotics, though greatly reducing the incidence of neurosyphilitic psychosis, may well have increased the mutability of the disease as reflected in its changing prevalence, distribution and clinical characteristics.

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