scholarly journals Phase variation and host immunity against high molecular weight (HMW) adhesins shape population dynamics of nontypeable Haemophilus influenzae within human hosts

2014 ◽  
Vol 355 ◽  
pp. 208-218 ◽  
Author(s):  
Gregg S. Davis ◽  
Simeone Marino ◽  
Carl F. Marrs ◽  
Janet R. Gilsdorf ◽  
Suzanne Dawid ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Population Dynamics ◽  
Haemophilus Influenzae ◽  
High Molecular Weight ◽  
Phase Variation ◽  
Host Immunity ◽  
Nontypeable Haemophilus Influenzae

scholarly journals Identification of New hmwA Alleles from Nontypeable Haemophilus influenzae

2005 ◽  
Vol 73 (2) ◽  
pp. 1221-1225 ◽  
Author(s):  
I. Zafer Ecevit ◽  
Kirk W. McCrea ◽  
Carl F. Marrs ◽  
Janet R. Gilsdorf
Keyword(s):  
Molecular Weight ◽  
Epithelial Cells ◽  
Haemophilus Influenzae ◽  
High Molecular Weight ◽  
Nontypeable Haemophilus Influenzae ◽  
Dna Variation ◽  
High Molecular Weight Proteins ◽  
Different Strains ◽  
High Degree ◽  
New Alleles

ABSTRACT High-molecular-weight proteins of Haemophilus influenzae mediate attachment to epithelial cells. Previous reports describe several allelic versions of hmwA genes that have different adherence properties. Here we report three new alleles of hmwA (hmwA from strain AAr96, hmwA from strain AAr105, and hmwA from strain G822), demonstrating the high degree of DNA variation of these genes among different strains.

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