scholarly journals Erythropoietin protects the central nervous system during prolonged hypothermic circulatory arrest: An experimental study in a canine model

2006 ◽  
Vol 131 (6) ◽  
pp. 1331-1337 ◽  
Author(s):  
Mitsuhiro Kawata ◽  
Shinichi Takamoto ◽  
Kazuo Kitahori ◽  
Hiroyuki Tsukihara ◽  
Tetsuro Morota ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Experimental Study ◽  
Nervous System ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
The Central Nervous System

Clinical neurologic and developmental studies after cardiac surgery utilizing hypothermic circulatory arrest and cardiopulmonary bypass

1993 ◽  
Vol 3 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Gil Wernovsky ◽  
Richard A. Jonas ◽  
Paul R. Hickey ◽  
Adré J. du Plessis ◽  
Jane W. Newburger
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Circulatory Arrest ◽  
Neurodevelopmental Outcome ◽  
Hypothermic Circulatory Arrest ◽  
Cerebral Injury ◽  
Profound Hypothermia ◽  
The Central Nervous System

The dramatic reduction in surgical mortality associated with repair of congenital heart anomalies in recent decades has been accompanied by a growing recognition of adverse neurologic sequels in some of the survivors. Abnormalities of the central nervous system may be a function of coexisting cerebral abnormalities or acquired events unrelated to surgical management (such as paradoxical embolus, cerebral infection, or effects of chronic cyanosis), but insults to the central nervous system appear to occur most frequently during or immediately after surgery. In particular, techniques of support used during neonatal and infant cardiac surgery—cardiopulmonary bypass, profound hypothermia and circulatory arrest—have been implicated as important causes of cerebral injury. This paper will review the effects of bypass and deep hypothermic circulatory arrest on neurodevelopmental outcome.

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