scholarly journals Long-term survival after non–small cell lung cancer surgery: Development and validation of a prognostic model with a preoperative and postoperative mode

2006 ◽  
Vol 132 (3) ◽  
pp. 491-498 ◽  
Author(s):  
Özcan Birim ◽  
A. Pieter Kappetein ◽  
Marco Waleboer ◽  
John P.A. Puvimanasinghe ◽  
Marinus J.C. Eijkemans ◽  
...  
2016 ◽  
Vol 30 (4) ◽  
pp. 930-935 ◽  
Author(s):  
Juan P. Cata ◽  
Justin Jones ◽  
Boris Sepesi ◽  
Reza J. Mehran ◽  
Andrea Rodriguez-Restrepo ◽  
...  

2014 ◽  
Vol 76 (5) ◽  
pp. 218 ◽  
Author(s):  
Myoung-Rin Park ◽  
Yeon-Hee Park ◽  
Jae-Woo Choi ◽  
Dong-Il Park ◽  
Chae-Uk Chung ◽  
...  

2020 ◽  
Vol 2020 ◽  
Author(s):  
Sara Ricciardi ◽  
Federico Davini ◽  
Carmelina C. Zirafa ◽  
Gaetano Romano ◽  
Franca M. A. Melfi

1988 ◽  
Vol 6 (7) ◽  
pp. 1161-1169 ◽  
Author(s):  
D V Jackson ◽  
L D Case ◽  
P J Zekan ◽  
B L Powell ◽  
R D Caldwell ◽  
...  

The effect of adding the epipodophyllotoxin etoposide (VP-16-213) to a standard chemotherapy regimen for patients with extensive stage small-cell lung cancer was evaluated during a randomized trial. Chemotherapy consisted of vincristine, doxorubicin, and cyclophosphamide (VAC) alone or with etoposide (EVAC). Of 139 patients enrolled, 136 patients were eligible for study and all but five were evaluable for response. The overall objective response was 46% in the VAC group v 70% in the etoposide-treated group (P = .008) with complete response (CR) rates of 12% v 29%, respectively (P = .030). Although the time to the observation of disease progression was significantly longer in the group of patients receiving etoposide (9.6 v 6.5 months, P = .010), overall survival was similar; this was probably due to administration of other agents including etoposide at the time of VAC failure. However, there were noteworthy differences in long-term (greater than or equal to 2 year) survival. Whereas only four (6%) patients treated with VAC lived 2 years, 11 (16%) of the etoposide-treated group did so (P = .100). Two-year failure-free survival was attained in one (2%) of the VAC patients and eight (11%) of the patients treated with etoposide (P = .034). Long-term survivorship, heretofore usually reported in patients with limited stage disease after a variety of treatments, may be possible with this drug combination in the setting of extensive disease.


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