P45.12 Renal Function Change During Alectinib in ALK Rearranged Non-Small Cell Lung Cancer: A Retrospective Multicentre Analysis

2021 ◽  
Vol 16 (10) ◽  
pp. S1090
Author(s):  
D. Pignataro ◽  
C. Paratore ◽  
M. Di Maio ◽  
M. Tucci ◽  
S. Novello
2020 ◽  
Vol 76 (11) ◽  
pp. 1573-1580
Author(s):  
Louis Magali ◽  
Foucher Pascal ◽  
Aho Serge ◽  
Boulin Mathieu ◽  
Zouak Ayoube ◽  
...  

1998 ◽  
Vol 34 (1) ◽  
pp. 199-202 ◽  
Author(s):  
J.A Gietema ◽  
H.J.M Groen ◽  
S Meijer ◽  
E.F Smit

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Panagiotis I. Georgianos ◽  
Vasilios Vaios ◽  
Eleni Leontaridou ◽  
Georgia Karayannopoulou ◽  
Triantafyllia Koletsa ◽  
...  

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3.5 months after initiation of immunotherapy with nivolumab. Urinalysis revealed sterile pyuria, without microscopic hematuria or proteinuria. Immunological examination was negative. A renal biopsy showed severe interstitial inflammatory infiltration of T-cells, monocytes, and eosinophils without interstitial granulomas and normal appearance of glomeruli, indicating acute interstitial nephritis (AIN) as the cause of AKI. After a short-term course of corticosteroids and permanent nivolumab discontinuation, partial recovery of renal function was noted. AIN is a rare adverse effect of ICPIs that mandates the close monitoring of renal function in patients under immunotherapy with these agents.


2020 ◽  
Vol 45 (5) ◽  
pp. 1153-1158 ◽  
Author(s):  
Kelly L. Niggebrugge‐Mentink ◽  
Marieke M. Beex‐Oosterhuis ◽  
Peter G. J. Horst ◽  
Matthijs E. C. Poll ◽  
Hetty G. Dieleman ◽  
...  

2016 ◽  
Vol 37 (4) ◽  
pp. 363-373 ◽  
Author(s):  
Weiwei Tan ◽  
Shinji Yamazaki ◽  
Theodore R. Johnson ◽  
Rong Wang ◽  
Melissa T. O’Gorman ◽  
...  

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