P68.10 PFN1 Induces Tumor Metastasis Through Promoting Secretion of Microvesicles By ROCK I/p-MLC Pathway in Non-Small Cell Lung Cancer

2021 ◽  
Vol 16 (10) ◽  
pp. S1203
Author(s):  
Y. Wang ◽  
C. Hu ◽  
Y. Lu
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals MiR-7-5p suppresses tumor metastasis of non-small cell lung cancer by targeting NOVA2

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Haiping Xiao
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Underlying Mechanism ◽  
Small Cell ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Small Cell Lung

Abstract Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Distant metastasis is thought to be one of the most important factors responsible for the failure of NSCLC therapy. MicroRNA-7-5p (miR-7-5p) has been demonstrated to be a tumor suppressor in breast cancer, hepatocarcinoma, prostate cancer and glioblastoma multiforme (GBM). However, its role in NSCLC is still not fully understood. This study evaluated the role of miR-7-5p in the progression of NSCLC and explored the underlying mechanism. Materials & methods The quantitative real-time PCR (qPCR), MTT, migration and invasion assays were used to evaluate the effects of miR-7-5p on the proliferation, migration and invasion of A549 and SPCA-1 cells. A tumor xenograft model was created to determine the effects of miR-7-5p on metastasis in vivo. The dual-luciferase reporter gene, neuro-oncological ventral antigen 2 (NOVA2) overexpression and western blotting assays were performed to explore the underlying mechanism. Results MiR-7-5p is downregulated in NSCLC tissues and lung cancer cell lines. It suppresses proliferation, migration, invasion and EMT marker expression in vitro and in vivo. Further study showed that miR-7-5p suppresses tumor metastasis of NSCLC by targeting NOVA2. Overexpression of NOVA2 attenuates the miR-7-5p-mediated inhibitory effect on lung cancer cells. Conclusion MiR-7-5p suppresses NSCLC metastasis. Targeting miR-7-5p may contribute to the success of NSCLC therapy.

scholarly journals FoxM1 Is Associated with Poor Prognosis of Non-Small Cell Lung Cancer Patients through Promoting Tumor Metastasis

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59412 ◽  
Author(s):  
Nuo Xu ◽  
Deshui Jia ◽  
Wenfeng Chen ◽  
Hao Wang ◽  
Fanglei Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lung Cancer ◽  
2012 ◽  
Vol 77 (3) ◽  
pp. 585-592 ◽  
Author(s):  
Fang-Yi Lo ◽  
Hsiung-Ting Chen ◽  
Hung-Chi Cheng ◽  
Han-Shui Hsu ◽  
Yi-Ching Wang
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Poor Survival

DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer

2019 ◽  
Vol 374 (2) ◽  
pp. 304-314 ◽  
Author(s):  
Jing Li ◽  
Tao Yu ◽  
Mingxia Yan ◽  
Xiao Zhang ◽  
Li Liao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Small Cell Lung

FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer

2018 ◽  
Vol 25 (4) ◽  
pp. 1302-1317 ◽  
Author(s):  
Lingyu Li ◽  
Wei Li ◽  
Naifei Chen ◽  
Haixin Zhao ◽  
Guang Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Circular Rnas ◽  
Small Cell Lung ◽  
Oncogenic Driver

scholarly journals Neuron specific enolase promotes tumor metastasis by activating the Wnt/β-catenin pathway in small cell lung cancer

2021 ◽  
Vol 14 (4) ◽  
pp. 101039
Author(s):  
Zhiqiang Zha ◽  
Dailing Li ◽  
Peiling Zhang ◽  
Peipei Wang ◽  
Xisheng Fang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Neuron Specific Enolase ◽  
Small Cell ◽  
Small Cell Lung

Prognostic Value of Serum IL-17 and VEGF Levels in Small Cell Lung Cancer

2015 ◽  
Vol 30 (4) ◽  
pp. 359-363 ◽  
Author(s):  
Qunying Lin ◽  
Lei Xue ◽  
Tian Tian ◽  
Bo Zhang ◽  
Lijing Guo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Prognostic Value ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Control Group ◽  
Small Cell Lung ◽  
Tumor Dissemination

Objective To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC). Materials and Methods IL-17 and VEGF levels were determined by a commercially available ELISA method. Results Serum IL-17 and VEGF levels were higher in the SCLC group than the control group (p<0.001 and p<0.0001, respectively). In addition, there was a significant correlation between IL-17 and VEGF. The level of IL-17 showed significant correlations with tumor stage and tumor metastasis, while serum VEGF levels were significantly associated only with tumor metastasis. Univariate and multivariate analysis indicated that an elevated IL-17 level was an independent prognostic factor for shorter overall survival in SCLC. Conclusions IL-17 may play an important role in tumor dissemination in SCLC patients and measurement of IL-17 could have useful prognostic value for worse overall survival in patients with SCLC.

scholarly journals Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 99801-99815 ◽  
Author(s):  
Shuai Zhang ◽  
Dehai Che ◽  
Fang Yang ◽  
Chunling Chi ◽  
Hongxue Meng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Associated Macrophages
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