scholarly journals Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies

2019 ◽  
Vol 17 (3) ◽  
pp. 589-614 ◽  
Author(s):  
Seungwon An ◽  
Ilangovan Raju ◽  
Bayasgalan Surenkhuu ◽  
Ji-Eun Kwon ◽  
Shilpa Gulati ◽  
...  
Keyword(s):  
Dry Eye ◽  
Neutrophil Extracellular Traps ◽  
Therapeutic Strategies ◽  
Pathological Changes ◽  
Host Disease ◽  
Extracellular Traps ◽  
Graft Vs Host Disease ◽  
Novel Biomarkers

scholarly journals On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2079
Author(s):  
Michal Santocki ◽  
Elzbieta Kolaczkowska
Keyword(s):  
Neutrophil Extracellular Traps ◽  
Therapeutic Strategies ◽  
Neutrophil Extracellular Trap ◽  
Know How ◽  
Extracellular Traps ◽  
Pathological Conditions ◽  
Extracellular Trap

Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they are removed in mild pathophysiological conditions and why their removal is impaired in multiple severe pathological conditions. Herein, we bring together all data available up till now on how NETs are cleared—from engaged cells, their phenotypes, to involved enzymes and molecules. Moreover, we hypothesize on why NET removal is challenged in multiple disorders and propose further directions for studies on NET removal as well as possible therapeutic strategies to have them cleared.

scholarly journals Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2143 ◽  
Author(s):  
Yasir Alhamdi ◽  
Cheng-Hock Toh
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Cell Injury ◽  
Neutrophil Extracellular Traps ◽  
Intravascular Coagulation ◽  
Extracellular Traps ◽  
Complex Interactions ◽  
Recent Advances ◽  
Novel Biomarkers

Disseminated intravascular coagulation (DIC) is an acquired condition that develops as a complication of systemic and sustained cell injury in conditions such as sepsis and trauma. It represents major dysregulation and increased thrombin generationin vivo. A poor understanding and recognition of the complex interactions in the coagulation, fibrinolytic, inflammatory, and innate immune pathways have resulted in continued poor management and high mortality rates in DIC. This review focuses attention on significant recent advances in our understanding of DIC pathophysiology. In particular, circulating histones and neutrophil extracellular traps fulfil established criteria in DIC pathogenesis. Both are damaging to the vasculature and highly relevant to the cross talk between coagulation and inflammation processes, which can culminate in adverse clinical outcomes. These molecules have a strong potential to be novel biomarkers and therapeutic targets in DIC, which is still considered synonymous with ‘death is coming’.

scholarly journals NETs and oncologic process

2021 ◽  
Vol 15 (1) ◽  
pp. 107-116
Author(s):  
E. V. Slukhanchuk
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophil Extracellular Traps ◽  
Therapeutic Strategies ◽  
Innate Immune ◽  
Systemic Lupus ◽  
Extracellular Traps ◽  
Activated Neutrophils ◽  
Autoimmune Conditions

Neutrophil Extracellular Traps (NETs) represent the networks consisting of DNA, histones, and proteins produced by activated neutrophils. Such structures have been proved to play a crucial role in inducing neutrophil innate immune response in the pathogenesis of such autoimmune conditions as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, as well as in the pathogenesis of other non-infectious processes, e. g., clotting disorders, thrombosis, diabetes, atherosclerosis, vasculitis and oncology diseases. Recent studies on animal models and human pathologies have uncovered a tremendous role for NETs in tumor progression and metastasis. In this regard, NETs should be considered as pro-oncogenic substances, which further investigation will provide an opportunity to develop new therapeutic strategies.

Enhanced formation of neutrophil extracellular traps in patients with graft versus host disease

2015 ◽  
Vol 94 (12) ◽  
pp. 2081-2083
Author(s):  
Jianlin Qiao ◽  
Feng Zhu ◽  
Yun Liu ◽  
Yuanyuan Li ◽  
Pan Li ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Neutrophil Extracellular Traps ◽  
Host Disease ◽  
Graft Versus Host ◽  
Extracellular Traps

scholarly journals Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease

Eye ◽  
2008 ◽  
Vol 23 (1) ◽  
pp. 202-208 ◽  
Author(s):  
Y Ban ◽  
Y Ogawa ◽  
E Goto ◽  
M Uchino ◽  
N Terauchi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Lipid Layer ◽  
Host Disease ◽  
Graft Vs Host Disease

scholarly journals Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1383 ◽  
Author(s):  
Bhawna Tomar ◽  
Hans-Joachim Anders ◽  
Jyaysi Desai ◽  
Shrikant R. Mulay
Keyword(s):  
Distress Syndrome ◽  
Neutrophil Infiltration ◽  
Neutrophil Extracellular Traps ◽  
Therapeutic Strategies ◽  
The Novel ◽  
Extracellular Traps ◽  
Putative Target ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome, neutrophilia, and cytokine storm, along with severe inflammatory response syndrome or sepsis. Here, we propose the putative role of enhanced neutrophil infiltration and the release of neutrophil extracellular traps, complement activation and vascular thrombosis during necroinflammation in COVID-19. Furthermore, we discuss how neutrophilic inflammation contributes to the higher mortality of COVID-19 in patients with underlying co-morbidities such as diabetes and cardiovascular diseases. This perspective highlights neutrophils as a putative target for the immunopathologic complications of severely ill COVID-19 patients. Development of the novel therapeutic strategies targeting neutrophils may help reduce the overall disease fatality rate of COVID-19.

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