scholarly journals Nutritional modulation of blood pressure and vascular changes during severe menstrual cramps

2020 ◽  
Author(s):  
Uche C. Njoku ◽  
Peter U. Amadi ◽  
Joy A. Amadi
Keyword(s):  
Blood Pressure ◽  
Vascular Changes ◽  
Nutritional Modulation

Peripheral Vascular Changes and Ambulatory Blood Pressure Profiles

1993 ◽  
Vol 6 (12) ◽  
pp. 1033-1039 ◽  
Author(s):  
Daniel Duprez ◽  
Marc De Buyzere ◽  
Johan De Sutter ◽  
Tine De Backer ◽  
Denis L. Clement
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Vascular Changes ◽  
Peripheral Vascular ◽  
Pressure Profiles

scholarly journals PERIPHERAL VASCULAR REACTIONS IN ANAPHYLAXIS OF THE MOUSE

1949 ◽  
Vol 89 (6) ◽  
pp. 583-596 ◽  
Author(s):  
Philip D. McMaster ◽  
Heinz Kruse
Keyword(s):  
Blood Pressure ◽  
Anaphylactic Shock ◽  
Blood Stream ◽  
The Other ◽  
Vascular Changes ◽  
Peripheral Vascular ◽  
Arterial Spasm ◽  
Vascular Spasm ◽  
Arteries And Veins ◽  
Large Vessels

Pronounced vascular changes occurring in the ears and claws of mice during anaphylactic shock are described. Practically at once after a foreign serum (pig, horse, or rabbit) enters the blood stream of sensitized animals both the arterial and venous vessels undergo marked, local or generalized constriction in the organs mentioned. Usually spasm of the vessel walls occurs simultaneously in the arteries and veins, but it may appear first in the arteries, or occasionally in the veins. When venous spasm precedes arterial spasm, the true capillaries become distended with cells; if the reverse order holds, the ears appear bloodless. There is no active constriction or dilatation of capillaries; the capillary behavior follows passively the changes in the large vessels. Peripheral vascular spasm occurs while the carotid blood pressure is high, but a few minutes later, while this still holds true, the ear vessels begin to relax and the circulation is resumed. Shortly afterwards the blood pressure falls to levels far below normal, but the vessels remain open. If the circulation of one ear is obstructed while anaphylactic shock is produced, no vascular spasm occurs in it. Release of the obstruction during the animal's recovery results in belated constriction of the blood vessels of this ear although by now the vessels in the other ear are dilated and the general systolic blood pressure is very low. The vascular reactions in the ears appear to be uninfluenced by the blood pressure in the large vessels, and they are not a response to nervous stimuli. They are local in origin. The vascular changes are often not clearly perceptible in the gross but are plainly to be seen under a low power of the microscope. They occur in some sensitized mice exhibiting no manifest signs of shock, differing only in degree from the changes taking place when shock is severe or fatal.

Abstract P219: Exercise Training Normalizes Vascular Changes in Aging Hypertension Involving microRNAs Profile and Target Genes

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Tiago Fernandes ◽  
Fernanda R Roque ◽  
Vander J Neves ◽  
João L Penteado ◽  
André C Silveira ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Soleus Muscle ◽  
Femoral Artery ◽  
Target Genes ◽  
P Value ◽  
Baseline Heart Rate ◽  
Type I ◽  
Vascular Changes ◽  
Fold Enrichment

MiRNAs profile and target genes involved in hypertension-associated vascular changes were evaluated. In addition, we checked the therapeutic role of exercise training (ET) on these parameters. Spontaneously hypertensive rats (SHR) aged 6 months and their controls Wistar Kyoto (WKY) were divided into 4 groups: SHR, trained SHR (SHR-T), WKY and trained WKY (WKY-T). Swimming ET consisted of 60 min of duration, 1x/day/10 weeks, with 4% caudal body weight workload. SHR showed an increased in systolic blood pressure (207 ± 5.5 mmHg) compared to WKY (133 ± 3.9 mmHg) analyzed by tail-cuff system, with no changes in baseline heart rate. We observed a reduction in VO 2 peak (WKY: 62 ± 1.5; SHR: 53 ± 2.5 mL.kg -1 .min -1 ) accompanied by soleus muscle atrophy (fiber type I - WKY: 4039 ± 195; SHR: 2658 ± 53; type IIa - WKY: 2903 ± 182, SHR: 2050 ± 68; Intermediate - WKY: 2663 ± 136, SHR: 1967 ± 95 μm 2 ) in SHR. Vascular function of femoral artery was similar in SHR and WKY, however, wall-to-lumen ratio was increased in femoral artery (WKY: 0.17±0.01, SHR: 0.27±0.01 a.u.) and muscular arteriole (WKY: 0.54±0.02, SHR: 1.14±0.03 a.u.) accompanied by capillary rarefaction (WKY: 1.2 ± 0.05, SHR: 0.6 ± 0.03 capillary-to-fiber ratio) in soleus muscle from SHR vs. WKY. In contrast, ET promoted reduction in blood pressure and resting bradycardia in trained animals. ET corrected the VO 2 peak reduction, muscle wasting, microvascular remodeling in SHR-T toward control levels. ET downregulated 8 miRNAs (-96, -205, -182, -146b-5p, -140, -328a, -665, -1) and upregulated 3 miRNAs (-499, -208b and -99b) in SHR-T when compared to SHR. Bioinformatics study for functional analysis of the predicted targets genes for the 11 miRNAs restored by ET demonstrated enrichment of different signaling pathways including cell death (p value <0.001; Fold enrichment 16.78) and vascular development (p value < 0.001; Fold enrichment 10.62). Thus, targets involved in angiogenesis and vascular integrity by the VEGF/VEGFR2/AKT/eNOS/Bcl-2 pathway were impaired in hypertension and corrected by ET. The results support the hypothesis that the structural changes arising from the progression of hypertension may be regulated by a set of miRNAs and target genes; and ET participates in restoring the vascular remodeling.

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