Effects of aging and blood pressure on the structure of the thoracic aorta in SAM mice: a model of age-associated degenerative vascular changes

2001 ◽  
Vol 36 (1) ◽  
pp. 111-124 ◽  
Author(s):  
B.H Zhu ◽  
M Ueno ◽  
T Matsushita ◽  
H Fujisawa ◽  
N Seriu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thoracic Aorta ◽  
Vascular Changes ◽  
Effects Of Aging ◽  
Sam Mice

Peripheral Vascular Changes and Ambulatory Blood Pressure Profiles

1993 ◽  
Vol 6 (12) ◽  
pp. 1033-1039 ◽  
Author(s):  
Daniel Duprez ◽  
Marc De Buyzere ◽  
Johan De Sutter ◽  
Tine De Backer ◽  
Denis L. Clement
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Vascular Changes ◽  
Peripheral Vascular ◽  
Pressure Profiles

Case 16.16

2014 ◽  
pp. 789-789
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Blood Pressure ◽  
Thoracic Aorta ◽  
Resistant Hypertension ◽  
Lower Extremities ◽  
Filling Defect ◽  
Drug Resistant ◽  
Upper And Lower Extremities

82-year-old woman with drug-resistant hypertension and a blood pressure discrepancy between upper and lower extremities MIP image from 3D CE MRA of the thoracic aorta (Figure 16.16.1) shows an irregular filling defect in the distal thoracic aorta, which causes significant narrowing of the aorta. Coronal oblique reformatted image from the 3D CE MRA (...

Age-related changes in thoracic aorta of obese Zucker rats

1992 ◽  
Vol 262 (5) ◽  
pp. H1548-H1556 ◽  
Author(s):  
R. H. Cox ◽  
D. C. Kikta
Keyword(s):  
Blood Pressure ◽  
Thoracic Aorta ◽  
Muscle Activation ◽  
Systolic Pressure ◽  
Serum Levels ◽  
Zucker Rats ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Arterial Blood ◽  
Age Related

Studies were performed on the ontogeny of arterial blood pressure and functional properties of the thoracic aorta in lean (L) and obese (O) male Zucker rats at ages of 6-36 wk. Body weight was larger in the O than the L at all ages, with differences reaching values of 200-250 g at ages over 24 wk (at 33-36 wk: L = 510 +/- 9 and O = 730 +/- 15 g). Systolic blood pressure was lower in young O compared with L (6-15 wk) but increased with age at a rate seven times greater in O than in L. For ages of 33-36 wk, systolic pressure was significantly higher in O compared with L (O = 132 +/- 2 vs. L = 122 +/- 2 mmHg). Total serum cholesterol (at 36 wk: L = 278 +/- 31 and O = 354 +/- 12 mg/dl) and triglycerides (at 36 wk: L = 493 +/- 71 and O = 1,618 +/- 220 mg/dl), as well as glucose levels, increased with age in both groups and were significantly higher in O at all ages. Serum levels of thyroxine but not triiodothyronine were significantly lower in O at all ages. No differences were found in passive mechanics at any age. Values of maximum active stress with smooth muscle activation by 75 mM K+ plus 10 microM norepinephrine were significantly higher at 24 and 36 wk in O (at 36 wk: L = 573 +/- 42 and O = 821 +/- 89 x 10(3) dyn/m2).(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of Aging on the Glomerular Capillaries, Blood Pressure, and Renal Function in Rats

2015 ◽  
pp. 157-162 ◽  
Author(s):  
Hans-Joachim Schurek ◽  
Janusz Panzer ◽  
Andreas Wiemeyer ◽  
Karlwilhelm K�hn ◽  
Bernhard Aeikens ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Effects Of Aging ◽  
Glomerular Capillaries

Effects of Aging on the Variability of Arterial Pressure in Essential Hypertensive Patients

1982 ◽  
Vol 63 (s8) ◽  
pp. 411s-414s ◽  
Author(s):  
Jun Ogawa ◽  
Shigeo Takata ◽  
Gakuji Nomura ◽  
Shiro Arai ◽  
Takayuki Ikeda ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Stroke Volume ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pulse Pressure ◽  
Baroreflex Sensitivity ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Average Systolic Blood Pressure ◽  
Effects Of Aging

1. We studied the effects of aging on the variability of blood pressure in mild to moderate essential hypertensive subjects. 2. Cardiac index was greater and total peripheral resistance index was less in patients under 40 years (by an average of 1.06 litres min−1 m−2 and 9.23 mmHg 1−1 min−1 m−2) than in those over 40 respectively (P < 0.001 for each). 3. Pulse pressure/stroke volume was less by an average of 0.345 mmHg/ml in patients under 40 years than that in those over 40 (P < 0.001). Pulse pressure/stroke volume was correlated with age (r = 0.621), average systolic blood pressure (r = 0.623) and inversely with baroreflex sensitivity (r = −0.494). 4. Baroreflex sensitivity was less by an average of 3.1 ms/mmHg in patients over 30 years than in those under 30 (P < 0.025). Baroreflex sensitivity was inversely correlated with age (r = −0.617) and average systolic blood pressure (r = −0.589). 5. Beat by beat variability of systolic blood pressure was correlated with age (r = 0.460), particularly when the data of those in their twenties were excluded (r = 0.618), and significantly with pulse pressure/stroke volume (r = 0.650), average systolic blood pressure (r = 0.618) and inversely with baroreflex sensitivity (r = −0.477). These relationships were not observed for diastolic blood pressure. 6. Maximum difference in systolic blood pressure in a day was correlated with pulse pressure/stroke volume (r = 0.482) and average systolic blood pressure (r = 0.648) but not with baroreflex sensitivity. These relationships were not observed for diastolic blood pressure. 7. Variability of systolic blood pressure in patients over 30 years gradually increased with age. In contrast, those of systolic and diastolic blood pressures in subjects in their twenties were relatively large. This might be related to factors other than aging, presumably those which underlie the hyperdynamic circulatory state.

scholarly journals Effects of Aging on Blood Pressure Variability in Resting Conditions

1995 ◽  
Vol 39 (2) ◽  
pp. 101
Author(s):  
DERK P. VEERMAN ◽  
BEN P. M. IMHOLZ ◽  
WOUTER WIELING ◽  
JOHN M. KAREMAKER ◽  
GERI A. VAN MONTFRANS
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Effects Of Aging

scholarly journals Products of Sulfide/Selenite Interaction Possess Antioxidant Properties, Scavenge Superoxide-Derived Radicals, React with DNA, and Modulate Blood Pressure and Tension of Isolated Thoracic Aorta

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Marian Grman ◽  
Anton Misak ◽  
Lucia Kurakova ◽  
Vlasta Brezova ◽  
Sona Cacanyiova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thoracic Aorta ◽  
Biological Effects ◽  
Antioxidant Properties ◽  
Relaxation Effect ◽  
Molar Ratio ◽  
Signalling Molecule ◽  
Biphasic Effect ◽  
Antioxidant Effects ◽  
Preincubation Time

Selenium (Se), an essential trace element, and hydrogen sulfide (H2S), an endogenously produced signalling molecule, affect many physiological and pathological processes. However, the biological effects of their mutual interaction have not yet been investigated. Herein, we have studied the biological and antioxidant effects of the products of the H2S (Na2S)/selenite (Na2SeO3) interaction. As detected by the UV-VIS and EPR spectroscopy, the product(s) of the H2S-Na2SeO3 and H2S-SeCl4 interaction scavenged superoxide-derived radicals and reduced ⋅cPTIO radical depending on the molar ratio and the preincubation time of the applied interaction mixture. The results confirmed that the transient species are formed rapidly during the interaction and exhibit a noteworthy biological activity. In contrast to H2S or selenite acting on their own, the H2S/selenite mixture cleaved DNA in a bell-shaped manner. Interestingly, selenite protected DNA from the cleavage induced by the products of H2S/H2O2 interaction. The relaxation effect of H2S on isolated thoracic aorta was eliminated when the H2S/selenite mixture was applied. The mixture inhibited the H2S biphasic effect on rat systolic and pulse blood pressure. The results point to the antioxidant properties of products of the H2S/selenite interaction and their effect to react with DNA and influence cardiovascular homeostasis. The effects of the products may contribute to explain some of the biological effects of H2S and/or selenite, and they may imply that a suitable H2S/selenite supplement might have a beneficial effect in pathological conditions arisen, e.g., from oxidative stress.

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