Mechanisms of Action of Eicosapentaenoic Acid in Bladder Cancer Cells In Vitro: Alterations in Mitochondrial Metabolism, Reactive Oxygen Species Generation and Apoptosis Induction

2009 ◽  
Vol 181 (4) ◽  
pp. 1885-1893 ◽  
Author(s):  
Alison Colquhoun
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Eicosapentaenoic Acid ◽  
Cancer Cells ◽  
Reactive Oxygen Species Generation ◽  
Mechanisms Of Action ◽  
Oxygen Species ◽  
Apoptosis Induction ◽  
Bladder Cancer Cells

scholarly journals Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells

1997 ◽  
Vol 76 (2) ◽  
pp. 206-210 ◽  
Author(s):  
A Miyajima ◽  
J Nakashima ◽  
K Yoshioka ◽  
M Tachibana ◽  
H Tazaki ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Bladder Cancer Cells ◽  
In Cis

scholarly journals Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5312
Author(s):  
Ana T. P. C. Gomes ◽  
M. Graça P. M. S. Neves ◽  
Rosa Fernandes ◽  
Carlos F. Ribeiro ◽  
José A. S. Cavaleiro ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Oxygen Formation ◽  
Bladder Cancer Cells ◽  
Photodynamic Activity ◽  
Singlet Oxygen Formation

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.

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