PD7-02 DELETION OF THE TRPV4 CATION CHANNEL LEADS TO DECREASED SENSORY INPUT INTO THE CENTRAL NERVOUS SYSTEM DURING THE MICTURITION CYCLE: A PET IMAGING STUDY IN RATS

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Yves Deruyver ◽  
Roma Rietjens ◽  
Jan Franken ◽  
Ann Van Santvoort ◽  
Cindy Casteels ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pet Imaging ◽  
Sensory Input ◽  
Imaging Study ◽  
Cation Channel ◽  
The Central Nervous System

scholarly journals Positron emission tomography reporter gene strategy for use in the central nervous system

2019 ◽  
Vol 116 (23) ◽  
pp. 11402-11407 ◽  
Author(s):  
Tom Haywood ◽  
Corinne Beinat ◽  
Gayatri Gowrishankar ◽  
Chirag B. Patel ◽  
Israt S. Alam ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Central Nervous System ◽  
Nervous System ◽  
Reporter Gene ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Great Promise ◽  
Adeno Associated Virus ◽  
Positron Emission ◽  
The Central Nervous System

There is a growing need for monitoring or imaging gene therapy in the central nervous system (CNS). This can be achieved with a positron emission tomography (PET) reporter gene strategy. Here we report the development of a PET reporter gene system using the PKM2 gene with its associated radiotracer [18F]DASA-23. The PKM2 reporter gene was delivered to the brains of mice by adeno-associated virus (AAV9) via stereotactic injection. Serial PET imaging was carried out over 8 wk to assess PKM2 expression. After 8 wk, the brains were excised for further mRNA and protein analysis. PET imaging at 8 wk post-AAV delivery showed an increase in [18F]DASA-23 brain uptake in the transduced site of mice injected with the AAV mice over all controls. We believe PKM2 shows great promise as a PET reporter gene and to date is the only example that can be used in all areas of the CNS without breaking the blood–brain barrier, to monitor gene and cell therapy.

scholarly journals Mechanical loading of a long bone induces plasticity in sensory input to the central nervous system

2009 ◽  
Vol 463 (3) ◽  
pp. 254-257 ◽  
Author(s):  
Qiang Wu ◽  
Susannah J. Sample ◽  
Theresa A. Baker ◽  
Cathy F. Thomas ◽  
Mary Behan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mechanical Loading ◽  
Sensory Input ◽  
Long Bone ◽  
The Central Nervous System

AIRFLOW SENSORS IN THE AVIAN WING

1993 ◽  
Vol 179 (1) ◽  
pp. 13-30 ◽  
Author(s):  
R. E. Brown ◽  
M. R. Fedde
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sensory Input ◽  
Separation Point ◽  
Discharge Frequency ◽  
Airflow Velocity ◽  
Discharge Characteristics ◽  
Distal Half ◽  
The Central Nervous System ◽  
Stimulation Of

Mechanoreceptors on or near feather follicles in the wings of birds may provide information about airflow over the wing. We studied discharge characteristics of rapidly and slowly adapting mechanoreceptors associated with propatagial covert feathers, slowly adapting receptors within the alular joint and vibration-sensitive receptors of filoplume follicles attached to the follicles of secondary flight feathers during manual feather movements and during airflow over the wing. Dorsal elevation of covert feathers produced an increase in discharge frequency related to the angle of elevation. Extension of the alula produced an increase in discharge frequency related to the angle of extension. Stimulation of receptors located on the distal half of the follicles of secondary flight feathers by airflow over the wing produced a continuous discharge whose frequency correlated with airflow velocity. There is thus abundant sensory input from the wing to the central nervous system. We conclude that birds have the necessary sensor-feather mechanisms in the wing (1) to detect an imminent stall and the location of the separation point of the airflow from the wing's surface, and (2) to measure airspeed by detecting the frequency of vibration of the secondary flight feathers.

The significance of palpation by the maxillary palps of Locusta migratoria (L): an electrophysiological and behavioural study

1975 ◽  
Vol 63 (3) ◽  
pp. 701-712
Author(s):  
W. M. Blaney ◽  
A. M. Duckett
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sensory Input ◽  
Locusta Migratoria ◽  
Behavioural Study ◽  
The Central Nervous System ◽  
Maxillary Palps

Palpation increases the amount of sensory input reaching the central nervous system compared with that obtained from sustained contact but that increase is not essential to allow discrimination. During a meal on favoured food, phagostimulatory input from the palps is not needed to drive feeding. When less favoured food is taken, phagostimulatory input from the palps may enhance feeding. Even with favoured food, the palps are important in registering inhibitory substances.

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