scholarly journals MP05-01 THE IMPACT OF CONTRALATERAL KIDNEY VOLUME ON RENAL FUNCTION AFTER RADICAL NEPHROURETERECTOMY: IMPLICATIONS FOR ELIGIBILITY FOR NEOADJUVANT CHEMOTHERAPY FOR UPPER TRACT UROTHELIAL CANCER

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Wan Song ◽  
Hyun Hwan Sung ◽  
Deok Hyun Han ◽  
Byong Chang Jeong ◽  
Seong Il Seo ◽  
...  
Keyword(s):  
Renal Function ◽  
Neoadjuvant Chemotherapy ◽  
Urothelial Cancer ◽  
Kidney Volume ◽  
Radical Nephroureterectomy ◽  
Contralateral Kidney ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer ◽  
The Impact

scholarly journals Treatment of Distal Upper Tract Urothelial Cancer with Distal Ureterectomy Preserves Renal Function without Increasing Local Recurrence Rate Compared with Radical Nephroureterectomy

2021 ◽  
Vol 5 (1) ◽  
pp. 86-90
Author(s):  
Mahesh Bahadur Adhikari ◽  
Woon Chau Tsang ◽  
Ho Yee Tiong
Keyword(s):  
Renal Function ◽  
Hospital Stay ◽  
Urothelial Carcinoma ◽  
Urothelial Cancer ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Duration Of Surgery ◽  
Upper Tract Urothelial Cancer ◽  
Distal Ureterectomy

Introduction: Kidney sparing surgery like endoscopic resection and distal ureterectomy has been recently proposed as alternative surgical options to manage distal Upper Tract Urothelial Cancer. This study aims to compare the surgical, oncological and functional outcomes of distal ureterectomy and Radical Nephroureterectomy for distal Upper Tract Urothelial Carcinoma.  Methods and Material: Out of 57 patients with Upper Tract Urothelial Carcinoma treated surgically at a single institution between 2010 and 2016, nineteen patients had distal Upper Tract Urothelial Carcinoma. A retrospective review was performed on these 19 patients (11 Radical Nephroureterectomy and 8 distal ureterectomy). Radical Nephroureterectomy was performed using an open or laparoscopic approach (n= 4 and 7 respectively). All Distal Ureterectomy patients were performed via an open extra-peritoneal Gibson incision. Pelvic lymphadenectomy and Subsequent ureteroneocystostomy in the Distal Ureterectomy group was performed directly and was augmented by psoas hitch or using boari flap reconstruction. Demographic, clinical features and post-operative outcomes were compared between the Radical Nephroureterectomy and Distal Ureterectomy groups.  Results: There was a trend towards shorter mean duration of surgery (238±34 vs. 286 ±90 min) and length of hospital stay (LOS) (7.6±2.8 vs. 17.3±20.7 days) in the Distal Ureterectomy group compared to the Radical Nephroureterectomy group (P=NS). Peri-operative Complication of Clavien grade 1-2 was seen in 4(33.33%) Radical Nephroureterectomy and 3 (37.5%) Distal Ureterectomy cases respectively. All patients had high grade Upper Tract Urothelial Carcinoma with equivalent pTNM staging in both groups with clear surgical margins. Immediate post-operative renal function improvement was statistically significant in the Distal Ureterectomy group (Radical Nephroureterectomy 2.27±5.93 vs 10.86±9.92 Distal Ureterectomy, p=0.034). Three out of 11 Radical Nephroureterectomy group patients required dialysis.  Conclusions: Local recurrences were similar after Distal Ureterectomy and Radical Nephroureterectomy with equivalent pathological outcomes in distal Upper Tract Urothelial Carcinoma. There was a clear trend towards shorter hospital stay and better renal function preservation in favor of Distal Ureterectomy with fewer patients requiring dialysis. 

The Impact of Sex Differences on Renal Function Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Retrospective Study

2021 ◽  
Author(s):  
Tsu-Ming Chien ◽  
Ching-Chia Li ◽  
Yen-Man Lu ◽  
Hsueh-Wei Chang ◽  
Yii-Her Chou ◽  
...  
Keyword(s):  
Renal Function ◽  
Sex Differences ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Clinicopathological Parameters ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Female Patients ◽  
Kaplan Meier ◽  
The Impact

Abstract Background: Upper tract urothelial carcinoma (UTUC) is a relatively rare type of urothelial carcinoma. Additionally, only few reports have examined the sex differences in patients with UTUC. Therefore, the present study aimed to identify the sex factors affecting renal function in patients with UTUC.Methods: Patients who underwent radical nephroureterectomy for non-metastatic UTUC between 2000 and 2013 were retrospectively reviewed and divided into two groups by sex. The Kaplan–Meier method was applied to evaluate the effects of sex on survival, whereas for the other clinicopathological parameters, hazard ratios were evaluated using the Cox regression model. The analyses were also performed in patients with different chronic kidney disease (CKD) stages.Results: A total of 368 patients were included, 147 men and 221 women. Female patients had a higher rate of anemia, advanced CKD stage, and dialysis. Male patients predominantly had a higher rate of smoking. The Kaplan–Meier analysis revealed no differences between sexes on metastasis-free survival (MFS) and cancer-specific survival. Multivariate analysis confirmed that ureteral tumors, advanced pathological tumor stage, and adjuvant chemotherapy indicated significantly worse survival outcomes in both sexes. However, only female patients with advanced CKD showed poorer MFS. After adjusting for renal function, the analysis found men had worse MFS.Conclusions: The female sex is significantly associated with a higher prevalence of advanced CKD among patients with UTUC in Taiwan. The impact of sex differences on renal function needs to be considered when evaluating survival.

scholarly journals Impact of Sex on Response to Neoadjuvant Chemotherapy in Patients with Upper-tract Urothelial Cancer

2020 ◽  
Vol 19 ◽  
pp. 16-19
Author(s):  
David D’Andrea ◽  
Beat Foerster ◽  
Surena F. Matin ◽  
Ja H. Ku ◽  
Tim Muilwijk ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Urothelial Cancer ◽  
Upper Tract ◽  
Upper Tract Urothelial Cancer ◽  
Response To Neoadjuvant Chemotherapy
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