PRS68 HEALTHCARE RESOURCE USE IN PATIENTS WITH SEVERE EOSINOPHILIC ASTHMA AFTER THE INITIATION OF MEPOLIZUMAB IN REAL-LIFE SETTINGS - REALITI-A STUDY

BackgroundLittle is known about the prevalence of severe, uncontrolled eosinophilic asthma (SUEA) and associated costs.AimsWe sought to determine the prevalence of SUEA and compare asthma-related healthcare resource use (HCRU) and associated costs with overall means for a general asthma population.MethodsThis cohort study evaluated anonymised medical record data (December 1989 through June 2015) from the Clinical Practice Research Datalink and the Optimum Patient Care Research Database to study UK patients with active asthma (diagnostic code and one or more drug prescriptions in the baseline year), aged 5 years and older, without concomitant COPD, and with recorded eosinophil count. SUEA was defined as two or more asthma attacks during 1 baseline year preceding a high blood eosinophil count (≥0.3×109/L) for patients prescribed long-acting β2-agonist (LABA) and high-dosage inhaled corticosteroids (ICS) during baseline plus 1 follow-up year. We compared asthma-related HCRU and associated direct costs (2015 pounds sterling, £) during the follow-up year for SUEA versus the general asthma population.ResultsOf 363 558 patients with active asthma and recorded eosinophil count, 64% were women, mean (SD) age was 49 (21) years; 43% had high eosinophil counts, 7% had two or more attacks in the baseline year and 10% were prescribed high-dosage ICS/LABA for 2 study years. Overall, 2940 (0.81%; 95% CI 0.78% to 0.84%) patients had SUEA. Total mean per-patient HCRU and associated costs were four times greater for SUEA versus all patients (HCRU and cost ratios 3.9; 95% CI 3.7 to 4.1).ConclusionsLess than 1% of patients in a general asthma population had SUEA. These patients accounted for substantially greater asthma-related HCRU and costs than average patients with asthma.

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Type D personality in Greek employees: Somatization, cardiovascular events and healthcare resource use

PsycEXTRA Dataset ◽

10.1037/e604062012-370 ◽

2012 ◽

Author(s):

Athanasios Lagoudis ◽

Christine Varvara ◽

Panagiotis Stafylas ◽

Stavros Gousopoulos

Keyword(s):

Resource Use ◽

Cardiovascular Events ◽

Healthcare Resource ◽

Type D Personality ◽

Healthcare Resource Use ◽

Type D

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Change in Patient-Reported Outcomes in Severe Eosinophilic Asthma Patients Treated With Benralizumab Under Real-life Conditions

Case Medical Research ◽

10.31525/ct1-nct04184284 ◽

2019 ◽

Author(s):

Keyword(s):

Patient Reported Outcomes ◽

Real Life ◽

Eosinophilic Asthma ◽

Severe Eosinophilic Asthma ◽

Life Conditions ◽

Patient Reported ◽

Asthma Patients

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Predictors of poor health and functional recovery following road trauma: protocol of a British Columbian inception cohort study

BMJ Open ◽

10.1136/bmjopen-2021-049623 ◽

2021 ◽

Vol 11 (4) ◽

pp. e049623

Author(s):

Leona K Shum ◽

Herbert Chan ◽

Shannon Erdelyi ◽

Lulu X Pei ◽

Jeffrey R Brubacher

Keyword(s):

Resource Use ◽

Healthcare Resource ◽

Healthcare Providers ◽

Healthcare Resource Use ◽

Physical And Mental Health ◽

Inception Cohort ◽

Policy Makers ◽

Productivity Costs ◽

Poor Outcome ◽

Lost Productivity

IntroductionRoad trauma (RT) is a major public health problem affecting physical and mental health, and may result in prolonged absenteeism from work or study. It is important for healthcare providers to know which RT survivors are at risk of a poor outcome, and policy-makers should know the associated costs. Unfortunately, outcome after RT is poorly understood, especially for RT survivors who are treated and released from an emergency department (ED) without the need for hospital admission. Currently, there is almost no research on risk factors for a poor outcome among RT survivors. This study will use current Canadian data to address these knowledge gaps.Methods and analysisWe will follow an inception cohort of 1500 RT survivors (16 years and older) who visited a participating ED within 24 hours of the accident. Baseline interviews determine pre-existing health and functional status, and other potential risk factors for a poor outcome. Follow-up interviews at 2, 4, 6, and 12 months (key stages of recovery) use standardised health-related quality of life tools to determine physical and mental health outcome, functional recovery, and healthcare resource use and lost productivity costs.Ethics and disseminationThe Road Trauma Outcome Study is approved by our institutional Research Ethics Board. This study aims to provide healthcare providers with knowledge on how quickly RT survivors recover from their injuries and who may be more likely to have a poor outcome. We anticipate that this information will be used to improve management of all road users following RT. Healthcare resource use and lost productivity costs will be collected to provide a better cost estimate of the effects of RT. This information can be used by policy-makers to make informed decisions on RT prevention programmes.

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