scholarly journals PNS9 Adverse Events Associated with External Reference Pricing in the USA

2020 ◽  
Vol 23 ◽  
pp. S645
Author(s):  
S. Bathija ◽  
M. Tang ◽  
N. Ngo ◽  
R. Macaulay
Keyword(s):  
Adverse Events ◽  
Reference Pricing ◽  
External Reference ◽  
The Usa

Naldemedine: Peripherally Acting Opioid Receptor Antagonist for Treating Opioid-induced Adverse Effects

2020 ◽  
Vol 20 (31) ◽  
pp. 2830-2842
Author(s):  
Masanao Inagaki ◽  
Toshiyuki Kanemasa ◽  
Takaaki Yokota
Keyword(s):  
Adverse Effects ◽  
Adverse Events ◽  
Severe Pain ◽  
Lead Compound ◽  
Inhibitory Effects ◽  
Pharmacokinetic Profiles ◽  
Structure Activity ◽  
The Usa ◽  
Relationship Study ◽  
The Eu

Opioids are widely used for pain management in moderate-to-severe pain. However, opioids are associated with adverse events, such as constipation and emesis/vomiting. To reduce these undesired effects, a structure–activity relationship study of morphinan derivatives was conducted, and a promising lead compound with inhibitory effects on opioid receptors was obtained. Further improvement in the potency and pharmacokinetic profiles of the lead compound led to the discovery of naldemedine, which showed anti-constipation and anti-emetic effects against these adverse events that were induced by morphine without influencing morphine’s analgesic effect. Naldemedine was launched in Japan and the USA in 2017 and in the EU in 2019, for treating opioid-induced constipation.

scholarly journals PNS170 CHEAP OR TIMELY DRUG? PRACTICAL IMPACT OF EXTERNAL REFERENCE PRICING POLICY IN THE EUROPEAN UNION

2019 ◽  
Vol 22 ◽  
pp. S790
Author(s):  
J. Laxton ◽  
T. Mlcoch ◽  
E. Zasukhina ◽  
M. Paris ◽  
T. Koubsky ◽  
...  
Keyword(s):  
European Union ◽  
The European Union ◽  
Pricing Policy ◽  
Reference Pricing ◽  
External Reference ◽  
Practical Impact

scholarly journals Overview Of External Reference Pricing Systems In Europe

2014 ◽  
Vol 17 (3) ◽  
pp. A12
Author(s):  
C. Rémuzat ◽  
D. Urbinati ◽  
J. Roïz ◽  
A. Kornfeld ◽  
M. Toumi
Keyword(s):  
Reference Pricing ◽  
External Reference

scholarly journals First Evaluation Of Colombian’s External Reference Pricing System

2014 ◽  
Vol 17 (3) ◽  
pp. A15 ◽  
Author(s):  
T. Andia ◽  
A. Gaviria ◽  
C. Gomez ◽  
L.F. Jaramillo ◽  
S. Marquez ◽  
...  
Keyword(s):  
Reference Pricing ◽  
External Reference ◽  
Pricing System

scholarly journals External Reference Pricing Impact of the Integration of the Amnog Discount In The List Price

2014 ◽  
Vol 17 (7) ◽  
pp. A423
Author(s):  
M. Thivolet ◽  
L. Cetinsoy ◽  
A.L. Vataire ◽  
C. Rémuzat ◽  
J. Brunet ◽  
...  
Keyword(s):  
List Price ◽  
Reference Pricing ◽  
External Reference

scholarly journals Nasogastric/nasoenteric tube-related adverse events: an integrative review

2021 ◽  
Vol 29 ◽  
Author(s):  
Ana Paula Gobbo Motta ◽  
Mayara Carvalho Godinho Rigobello ◽  
Renata Cristina de Campos Pereira Silveira ◽  
Fernanda Raphael Escobar Gimenes
Keyword(s):  
Adverse Events ◽  
Healthcare Professionals ◽  
Scientific Literature ◽  
Adult Patients ◽  
Respiratory Complications ◽  
Tube Obstruction ◽  
Tube Removal ◽  
Pressure Injury ◽  
The Usa ◽  
Evidence Based Guideline

Objective: to analyze in the scientific literature the evidence on nasogastric/nasoenteric tube related adverse events in adult patients. Method: integrative literature review through the search of publications in journals indexed in PubMed/MEDLINE, CINAHL, LILACS, EMBASE and Scopus, and hand searching, was undertaken up to April 2017. Results: the sample consisted of 69 primary studies, mainly in English and published in the USA and UK. They were divided in two main categories and subcategories: the first category refers to Mechanical Adverse Events (respiratory complications; esophageal or pharyngeal complications; tube obstruction; intestinal perforation; intracranial perforation and unplanned tube removal) and the second alludes to Others (pressure injury related to fixation and misconnections). Death was reported in 16 articles. Conclusion: nasogastric/nasoenteric tube related adverse events are relatively common and the majority involved respiratory harm that resulted in increased hospitalization and/or death. The results may contribute to healthcare professionals, especially nurses, to develop an evidence-based guideline for insertion and correct positioning of bedside enteral tubes in adult patients.

A case for external reference pricing to regulate drug costs in low- and middle-income countries

2021 ◽  
Vol 27 (10) ◽  
pp. 1-4
Author(s):  
Amirul Ashraf ◽  
Siew Chin Ong
Keyword(s):  
Drug Costs ◽  
Drug Pricing ◽  
Middle Income ◽  
Complex Issue ◽  
Middle Income Countries ◽  
Reference Pricing ◽  
External Reference ◽  
Low And Middle Income

Amirul Ashraf and Siew Chin Ong discuss external reference pricing as a possible method of navigating the complex issue of drug pricing in Malaysia.

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