scholarly journals Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis

2018 ◽  
Vol 94 (4) ◽  
pp. 756-772 ◽  
Author(s):  
Lili Zhou ◽  
Shan Zhou ◽  
Peng Yang ◽  
Yuan Tian ◽  
Zhiwei Feng ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Cannabinoid Receptor ◽  
Novel Approach ◽  
Targeted Inhibition

scholarly journals Cannabinoid receptor type 2 gene is associated with human osteoporosis

2005 ◽  
Vol 14 (22) ◽  
pp. 3389-3396 ◽  
Author(s):  
Meliha Karsak ◽  
Martine Cohen-Solal ◽  
Jan Freudenberg ◽  
Agnes Ostertag ◽  
Caroline Morieux ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2

scholarly journals Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain

2021 ◽  
Vol 22 (15) ◽  
pp. 8051
Author(s):  
Rodrigo Teodoro ◽  
Daniel Gündel ◽  
Winnie Deuther-Conrad ◽  
Lea Ueberham ◽  
Magali Toussaint ◽  
...  
Keyword(s):  
Cannabinoid Receptors ◽  
Cannabinoid Receptor ◽  
Biological Evaluation ◽  
Emission Tomography ◽  
Tailored Therapy ◽  
Positron Emission ◽  
Cannabinoid Receptor Type 2 ◽  
Attractive Therapeutic Target ◽  
The Brain

Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for neurodegenerative diseases and cancer. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor receptor density and/or occupancy during a CB2R-tailored therapy, we herein describe the radiosynthesis of cis-[18F]1-(4-fluorobutyl-N-((1s,4s)-4-methylcyclohexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide ([18F]LU14) starting from the corresponding mesylate precursor. The first biological evaluation revealed that [18F]LU14 is a highly affine CB2R radioligand with >80% intact tracer in the brain at 30 min p.i. Its further evaluation by PET in a well-established rat model of CB2R overexpression demonstrated its ability to selectively image the CB2R in the brain and its potential as a tracer to further investigate disease-related changes in CB2R expression.

scholarly journals A novel approach to glycemic control in type 2 diabetes mellitus, partial jejunal diversion: pre-clinical to clinical pathway

2017 ◽  
Vol 5 (1) ◽  
pp. e000431 ◽  
Author(s):  
Martin Fried ◽  
Karin Dolezalova ◽  
Adam P Chambers ◽  
Elliott J Fegelman ◽  
Robin Scamuffa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Clinical Pathway ◽  
Novel Approach

scholarly journals Selection of solar tracking system using extended TOPSIS technique with interval type-2 pythagorean fuzzy numbers

2021 ◽  
Author(s):  
Rimsha Umer ◽  
Muhammad Touqeer ◽  
Abdullah Hisam Omar ◽  
Ali Ahmadian ◽  
Soheil Salahshour ◽  
...  
Keyword(s):  
Fuzzy Numbers ◽  
Tracking System ◽  
Weighted Averaging ◽  
Distance Method ◽  
Novel Approach ◽  
Solar Tracking ◽  
Interval Type ◽  
Topsis Technique ◽  
Pythagorean Fuzzy Numbers

AbstractThe Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) is considered among the most frequently used techniques to deal with multi-criteria group decision-making (MCGDM) conflicts. In this article, we have presented an extended TOPSIS technique in the framework of interval type-2 trapezoidal Pythagorean fuzzy numbers (IT2TrPFN). We first projected a novel approach to evaluate the distance between them using ordered weighted averaging operator and $$(\alpha ,\beta )$$ ( α , β ) -cut. Subsequently, we widen the concept of TOPSIS method formed on the distance method with IT2TrPFNs and applied it on MCGDM dilemma by considering the attitudes and perspectives of the decision-makers. Lastly, an application of solar tracking system and numerous contrasts with the other existing techniques are presented to express the practicality and feasibility of our projected approach.

Sign in / Sign up

Export Citation Format

Share Document