Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: Modulation by Momordica charantia (karela) extract

Life Sciences ◽  
2004 ◽  
Vol 74 (12) ◽  
pp. 1503-1511 ◽  
Author(s):  
Haider Raza ◽  
Ijaz Ahmed ◽  
Annie John
Keyword(s):  
Immunohistochemical Localization ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
Glutathione S Transferase ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Tissue-specific expression of PPAR mRNAs in diabetic rats and divergent effects of cilostazol

2008 ◽  
Vol 86 (7) ◽  
pp. 465-471 ◽  
Author(s):  
Furong Wang ◽  
Ling Gao ◽  
Bendi Gong ◽  
Jianting Hu ◽  
Mei Li ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Renal Cortex ◽  
Expression Patterns ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
Peroxisome Proliferator ◽  
Specific Expression ◽  
Camp Content ◽  
Tissue Specific ◽  
Tissue Specific Expression

Cilostazol and ligands of peroxisome proliferator-activated receptors (PPARs) have been effectively used to alleviate diabetic complications, but the common and tissue-specific expression patterns of PPARs in different tissues in diabetic patients and those treated with cilostazol have not been reported. Here, we aimed to assess the effects of diabetes and cilostazol on mRNA expression of PPARα and PPARγ in the aorta, renal cortex, and retina of diabetic rats treated with cilostazol for 8 weeks. PPARα mRNA expression showed uniform downregulation in all these tissues in diabetic rats, and this effect was reversed by cilostazol treatment. Surprisingly, PPARγ mRNA expression was reduced in the renal cortex and retina, yet increased in the aorta of diabetic rats, although cilostazol still reversed these changes. Interestingly, cilostazol, a well-known phosphodiesterase 3 inhibitor and cAMP elevator, augmented cAMP content only in the aorta, but showed no significant effects in the renal cortex of diabetic rats. In conclusion, mRNA expression of PPARs is tissue-specific in diabetes and may be differently affected by cilostazol, possibly because of its tissue-specific effects on cAMP content.

Tissue-Specific Expression of the Uncoupling Protein Family in Streptozotocin-Induced Diabetic Rats

2008 ◽  
Vol 224 (3) ◽  
pp. 172-177
Author(s):  
Shuji Hidaka ◽  
Hironobu Yoshimatsu ◽  
Tetsuya Kakuma ◽  
Hiroshi Sakino ◽  
Seiya Kondou ◽  
...  
Keyword(s):  
Uncoupling Protein ◽  
Diabetic Rats ◽  
Protein Family ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Tissue-Specific Expression of the Uncoupling Protein Family in Streptozotocin-Induced Diabetic Rats

2000 ◽  
Vol 224 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Shuji Hidaka ◽  
Hironobu Yoshimatsu ◽  
Tetsuya Kakuma ◽  
Hiroshi Sakino ◽  
Seiya Kondou ◽  
...  
Keyword(s):  
Uncoupling Protein ◽  
Diabetic Rats ◽  
Protein Family ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Tissue-specific Expression and Subcellular Distribution of Murine Glutathione S-transferase Class Kappa

2004 ◽  
Vol 52 (5) ◽  
pp. 653-662 ◽  
Author(s):  
Rachel E. Thomson ◽  
Alison L. Bigley ◽  
John R. Foster ◽  
Ian R. Jowsey ◽  
Clifford R. Elcombe ◽  
...  
Keyword(s):  
Subcellular Distribution ◽  
Glutathione S Transferase ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Tissue-specific expression patterns of nuclear receptors

2013 ◽  
Author(s):  
AL Bookout ◽  
Y Jeong ◽  
M Downes ◽  
RT Yu ◽  
RM Evans ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Expression Patterns ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
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