This paper presents a time-domain hydroelastic analysis method for bridges supported by floating pontoons in inhomogeneous wave conditions. The inhomogeneous wave effect is accounted for by adopting different wave spectra over different regions along the structure, then the time history of inhomogeneous first-order wave excitation forces on the floating pontoons can be obtained. The frequency-domain hydrodynamic coefficients are transformed into the time-domain hydroelastic model using Cummins' equations. The linear hydroelastic responses of a curved floating bridge with end supports, subjected to irregular waves with spatially varying significant wave heights and peak periods, are investigated. Moreover, sensitive analyses are performed to study the effects of the inhomogeneity on the hydroelastic responses. The primary results indicate that the inhomogeneity of the waves has a significant effect on the dynamic responses of the floating bridge.