scholarly journals Tumor Microenvironment/NIR-responsive carbon monoxide delivery with hollow mesoporous CuS nanoparticles for MR imaging guided synergistic therapy

2021 ◽  
pp. 109731
Author(s):  
Shaohui Zheng ◽  
Peipei Dou ◽  
Shang Jin ◽  
Min Jiao ◽  
Wenjun Wang ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Tumor Microenvironment ◽  
Mr Imaging

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

2021 ◽  
Author(s):  
Endong Zhang ◽  
Zicheng Zuo ◽  
Wen Yu ◽  
Hao Zhao ◽  
Shengpeng Xia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Conjugated Polymer ◽  
Tumor Therapy ◽  
Living Cells ◽  
Tumor Treatment ◽  
Treatment Efficiency ◽  
Therapy Strategy ◽  
Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

Two-Photon Fluorescence and MR Bio-imaging of Endogenous H2O2 in Tumor Microenvironment by a Dual-Mode Nanoprobe

2021 ◽  
Author(s):  
Hongmei Zhong ◽  
Shengrong Yu ◽  
Bingqian Li ◽  
Kangdi He ◽  
Dian Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tumor Microenvironment ◽  
Mr Imaging ◽  
High Selectivity ◽  
Carbon Quantum Dots ◽  
Dual Mode ◽  
Two Photon ◽  
Bio Imaging ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based two-photon carbon quantum dots and MnO2, has been developed for two-photon fluorescence and MR imaging of endogenous H2O2 in tumor microenvironment, which achieved high selectivity,...

scholarly journals A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Li ◽  
Zeming Liu ◽  
Weng Zeng ◽  
Ziqi Wang ◽  
Chunping Liu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Tumor Site ◽  
Co Poisoning ◽  
Chemotherapy Agent ◽  
Manganese Carbonyl ◽  
Co Gas

Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intravenous injection, ZCM gradually accumulates in cancerous tissues, decomposing in the acidic tumor microenvironment, releasing CPT and MnCO. CPT acts as a chemotherapy agent destroying tumors and producing copious H2O2. MnCO can react with the H2O2 to generate CO, powerfully damaging the tumor. Both in vitro and in vivo experiments indicate that the ZCM system is both safe and has excellent tumor inhibition properties. ZCM is a novel system for CO controlled release, with significant potential to improve future cancer therapy.

Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

2020 ◽  
Vol 8 (18) ◽  
pp. 4056-4066 ◽  
Author(s):  
Qian Chen ◽  
Xueru Shan ◽  
Suqing Shi ◽  
Chunzhu Jiang ◽  
Tinghua Li ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mr Imaging ◽  
Tannic Acid ◽  
Core Shell ◽  
Composite Nanoparticle ◽  
Promising Application

A tannic acid–Fe3+ networks-functionalized polydopamine-based composite nanoparticle was constructed and demonstrated the promising application for T1/T2-weighted MR imaging-guided synergistic treatment of PTT and reductant/photothermal-enhanced CDT.

Carbon monoxide poisoning: Bilateral lesions in the thalamus on MR imaging of the brain

1990 ◽  
Vol 20 (6) ◽  
pp. 478-479 ◽  
Author(s):  
R. F. Tuchman ◽  
F. G. Moser ◽  
S. L. Moshé
Keyword(s):  
Carbon Monoxide ◽  
Mr Imaging ◽  
Carbon Monoxide Poisoning ◽  
Bilateral Lesions ◽  
The Brain
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