Synthesis of quinazolin-4(3H)-ones via electrochemical decarboxylative cyclization of α‑keto acids with 2-aminobenzamides

2021 ◽  
Vol 500 ◽  
pp. 111345
Author(s):  
Qing Tian ◽  
Jinli Zhang ◽  
Liang Xu ◽  
Yu Wei
Keyword(s):  
Keto Acids ◽  
Decarboxylative Cyclization

pH Dependence of the polarographic limiting currents of α-keto acids

1961 ◽  
Vol 26 (1) ◽  
pp. 141-155 ◽  
Author(s):  
S. Ono ◽  
M. Takagi ◽  
T. Wasa
Keyword(s):  
Ph Dependence ◽  
Keto Acids

scholarly journals THE INFLUENCE OF α-KETO ACIDS ON THE DESAMIDATION OF AMINO ACID AMIDES

1946 ◽  
Vol 165 (2) ◽  
pp. 741-742
Author(s):  
Jesse P. Greenstein ◽  
Charles E. Carter
Keyword(s):  
Amino Acid ◽  
Keto Acids

scholarly journals Interactions between Glutamate Dehydrogenase, Transaminases, and Keto Acids

1971 ◽  
Vol 246 (23) ◽  
pp. 7241-7249
Author(s):  
Leonard A. Fahien ◽  
Jia-Huey Lin-Yu ◽  
Susannah E. Smith ◽  
John M. Happy
Keyword(s):  
Glutamate Dehydrogenase ◽  
Keto Acids

scholarly journals Protometabolic Reduction of NAD+ with α-Keto Acids

JACS Au ◽  
2021 ◽  
Author(s):  
Shibaji Basak ◽  
Serge Nader ◽  
Sheref S. Mansy
Keyword(s):  
Keto Acids

scholarly journals Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
José C. Páez-Franco ◽  
Jiram Torres-Ruiz ◽  
Víctor A. Sosa-Hernández ◽  
Rodrigo Cervantes-Díaz ◽  
Sandra Romero-Ramírez ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Lung Damage ◽  
Amino Acid Supplementation ◽  
Enzymatic Conversion ◽  
Clinical Markers ◽  
Hypoxic Conditions ◽  
Oxygen Homeostasis ◽  
Keto Acids

AbstractWe identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.

Photochemical synthesis of 3-hydroxyphenanthro[9,10-c]furan-1(3H)-ones from α-keto acids and alkynes

2020 ◽  
Author(s):  
Beibei Zhao ◽  
Zhen Zhang ◽  
Yu Ge ◽  
Pinhua Li ◽  
Tao Miao ◽  
...  
Keyword(s):  
Efficient Method ◽  
Photochemical Synthesis ◽  
Keto Acids

A novel and efficient method for the synthesis of 3-hydroxyphenanthro[9,10-c]furan-1(3H)-ones has been achieved from readily available α-keto acids and alkynes through photo-initiated transformation, providing a range of structurally diverse products...

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