scholarly journals Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
José C. Páez-Franco ◽  
Jiram Torres-Ruiz ◽  
Víctor A. Sosa-Hernández ◽  
Rodrigo Cervantes-Díaz ◽  
Sandra Romero-Ramírez ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Lung Damage ◽  
Amino Acid Supplementation ◽  
Enzymatic Conversion ◽  
Clinical Markers ◽  
Hypoxic Conditions ◽  
Oxygen Homeostasis ◽  
Keto Acids

AbstractWe identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.

scholarly journals COVID-19 Metabolomic Profile: A Link Between Lung Dysfunction Markers and Altered Amino Acid Metabolism

2020 ◽  
Author(s):  
José C. Páez-Franco ◽  
José J. Torres-Ruíz ◽  
Víctor A. Sosa-Hernandez ◽  
Rodrigo Cervantes-Díaz ◽  
Sandra Romero-Ramírez ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Metabolism ◽  
Lung Damage ◽  
Amino Acid Supplementation ◽  
Enzymatic Conversion ◽  
Clinical Markers ◽  
Metabolomic Profile ◽  
Hypoxic Conditions ◽  
Keto Acids ◽  
Lung Dysfunction

Abstract We identified the main changes in serum metabolites associated with severe (n=46) and mild (n=19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three 𝛼-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of 𝛼-keto-acids to 𝛼- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.

Amino acid metabolism of dog jejunum before and during absorption of keto analogues.

1977 ◽  
Vol 232 (3) ◽  
pp. E263
Author(s):  
F L Weber ◽  
W C Maddrey ◽  
M Walser
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Arterial Blood ◽  
Keto Acids ◽  
Significant Release ◽  
Significant Uptake ◽  
Keto Analogues ◽  
Jejunal Wall

In fasting dogs, significant uptake by the jejunal wall from arterial blood was found for glutamine and eight other amino acids. Significant release into the mesenteric vein of ammonium, alanine, citrulline, and proline occurred, equal in nitrogen content to glutamine nitrogen taken up. The keto analogues of leucine, valine, and isoleucine, infused for 1 h into the lumen at initial concentrations of 10mM, disappeared from the lumen at 20.2 +/- 1.6, 18.6 +/- 2.0, and 15.7 +/- 2.8 mumol/cm in 1h, respectively. Eight fifteen and seventeen percent, respectively, of these absorbed quantities were released into mesenteric blood as leucine, valine, and isoleucine plus alloisoleucine, indicating significant amination of the keto acids by the gut wall. No significant changes were detected in the arteriovenous differences of any other amino acids or ammonium. The remainder of the absorbed analogues of valine and isoleucine appeared as such in the blood. In the case of the keto analogue of leucine, there was apparent degradation by the gut wall of 34% of the absorbed compound.

Amino Acid Metabolism in Plants. II. Transamination Reactions of Free Protein Amino Acids in Cell-Free Extracts of Cotyledons and Growing Tissues of Bushbean Seedlings (Phaseolus vulgaris L.)

1972 ◽  
Vol 50 (5) ◽  
pp. 538-542 ◽  
Author(s):  
J. C. Forest ◽  
F. Wightman
Keyword(s):  
Amino Acids ◽  
Protein Synthesis ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
The Other ◽  
Amino Group ◽  
Phaseolus Vulgaris L ◽  
Keto Acids ◽  
Protein Amino Acids

The different transaminase reactions for 22 protein amino acids were investigated in extracts of cotyledons and growing tissues of 8-day-old bushbean seedlings when either α-ketoglutarate, oxaloacetate, pyruvate, or glyoxylate was used as amino group acceptor. The results indicate that both cotyledons and growing tissues exhibited a similar pattern of transaminase activities with respect to the amino acids normally required for protein synthesis. It was found that with the exception of proline, hydroxyproline, and cystine which did not appear to be transaminated, and of serine and threonine which were transaminated only when pyruvate or glyoxylate was provided as the amino group acceptor, all the other 17 amino acids were transaminated to different extents when each of the four keto acids tested was supplied as the amino group acceptor. Glutamic acid, aspartic acid, and alanine were, by far, the best amino group donors and α-ketoglutarate was generally found to be the best amino acceptor. Consideration is given to the number and substrate specificity of the aminotransferases catalyzing the reactions demonstrated in this study.

Amino Acid Metabolism

1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Effect of intravenous bicarbonate administration on postoperative amino acid metabolism

1985 ◽  
Vol 4 ◽  
pp. 141-146 ◽  
Author(s):  
K VESTERBERG ◽  
J BERGSTROM ◽  
P FURST ◽  
U LEANDER ◽  
E VINNARS
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism
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