Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses

2014 ◽  
Vol 396 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Yaqin Tu ◽  
Qilin Yu ◽  
Guorun Fan ◽  
Ping Yang ◽  
Qiaohong Lai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Diabetes Risk ◽  
Adipoq Gene ◽  
Meta Analyses ◽  
Control Study

scholarly journals Dietary manganese, plasma markers of inflammation, and the development of type 2 diabetes in postmenopausal women: findings from the Women’s Health Initiative

2020 ◽  
Author(s):  
Jung Ho Gong ◽  
Kenneth Lo ◽  
Qing Liu ◽  
Jie Li ◽  
Shuiqing Lai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Diabetes Risk ◽  
Inflammatory Biomarkers ◽  
Health Initiative ◽  
Markers Of Inflammation ◽  
Control Study

Objective<b>: </b>To examine the association between manganese intake and the risk of type 2 diabetes in postmenopausal women and determine whether this association is mediated by circulating markers of inflammation. <p>Research Design and Methods: We included 84,285 postmenopausal women without history of diabetes from the national Women’s Health Initiative Observational Study (WHI-OS). Replication analysis was then conducted among 62,338 women participated in the WHI-Clinical Trial (WHI-CT). Additionally, data from a case-control study of 3,749 women nested in the WHI-OS with information on biomarkers of inflammation and endothelial dysfunction were examined using mediation analysis to determine the relative contributions of these known biomarkers by which manganese affect T2D risk.</p> <p>Results: Compared with the lowest quintile of energy-adjusted dietary manganese, WHI-OS participants in the highest quintile had a 30% lower risk of type 2 diabetes (hazards ratio [HR] 0.70 [95% CI 0.65, 0.76]). A consistent association was also confirmed in the WHI-CT (HR 0.79 [95% CI 0.73, 0.85]). In the nested case-control study, higher energy-adjusted dietary manganese was associated with lower circulating levels of inflammatory biomarkers that significantly mediated the association between dietary manganese and type 2 diabetes risk. Specifically, 19% and 12% of type 2 diabetes risk due to manganese were mediated through interleukin 6 and high-sensitivity C-reactive protein, respectively.</p> <p>Conclusions: Higher intake of manganese was directly associated with a lower type 2 diabetes risk independent of known risk factors. This association may be partially mediated by inflammatory biomarkers.</p>

scholarly journals Association of ADIPOQ Gene Variant rs266729 with Circulatory Adiponectin Levels in Patients with Type 2 Diabetes in North Indian Population: A Case-Control Study

2017 ◽  
Vol 10 (1) ◽  
pp. 407-417 ◽  
Author(s):  
Mohammad Mustufa Khan ◽  
Gyanendra Kumar Sonkar ◽  
Roshan Alam ◽  
Sangeeta Singh ◽  
Sudhir Mehrotra ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Indian Population ◽  
Case Control Study ◽  
Case Control ◽  
Gene Variant ◽  
North Indian Population ◽  
Adipoq Gene ◽  
Control Study

scholarly journals Dietary manganese, plasma markers of inflammation, and the development of type 2 diabetes in postmenopausal women: findings from the Women’s Health Initiative

2020 ◽  
Author(s):  
Jung Ho Gong ◽  
Kenneth Lo ◽  
Qing Liu ◽  
Jie Li ◽  
Shuiqing Lai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Diabetes Risk ◽  
Inflammatory Biomarkers ◽  
Health Initiative ◽  
Markers Of Inflammation ◽  
Control Study

Objective<b>: </b>To examine the association between manganese intake and the risk of type 2 diabetes in postmenopausal women and determine whether this association is mediated by circulating markers of inflammation. <p>Research Design and Methods: We included 84,285 postmenopausal women without history of diabetes from the national Women’s Health Initiative Observational Study (WHI-OS). Replication analysis was then conducted among 62,338 women participated in the WHI-Clinical Trial (WHI-CT). Additionally, data from a case-control study of 3,749 women nested in the WHI-OS with information on biomarkers of inflammation and endothelial dysfunction were examined using mediation analysis to determine the relative contributions of these known biomarkers by which manganese affect T2D risk.</p> <p>Results: Compared with the lowest quintile of energy-adjusted dietary manganese, WHI-OS participants in the highest quintile had a 30% lower risk of type 2 diabetes (hazards ratio [HR] 0.70 [95% CI 0.65, 0.76]). A consistent association was also confirmed in the WHI-CT (HR 0.79 [95% CI 0.73, 0.85]). In the nested case-control study, higher energy-adjusted dietary manganese was associated with lower circulating levels of inflammatory biomarkers that significantly mediated the association between dietary manganese and type 2 diabetes risk. Specifically, 19% and 12% of type 2 diabetes risk due to manganese were mediated through interleukin 6 and high-sensitivity C-reactive protein, respectively.</p> <p>Conclusions: Higher intake of manganese was directly associated with a lower type 2 diabetes risk independent of known risk factors. This association may be partially mediated by inflammatory biomarkers.</p>

scholarly journals Association of polymorphisms of the KCNQ1 and ADIPOQ genes with the prognosis of type 2 diabetes

2020 ◽  
pp. 95-96
Author(s):  
Е.С. Мельникова ◽  
О.Д. Рымар ◽  
А.А. Иванова ◽  
С.В. Мустафина ◽  
М.Ю. Шапкина ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Fragment Length Polymorphism ◽  
Statistical Processing ◽  
Case Control ◽  
Control Group ◽  
Kcnq1 Gene ◽  
Adipoq Gene ◽  
Control Study

Цель работы - изучение ассоциации однонуклеотидных полиморфизмов rs2237892 гена KCNQ1 и rs6773957 гена ADIPOQ с сахарным диабетом 2 типа (СД2). На основе проспективного обследования репрезентативной популяционной выборки жителей г.Новосибирска сформированы две группы по принципу «случай - контроль». Группа СД2 (n=443, средний возраст 56,2 лет, мужчины - 28,8%, женщины - 71,2%), группа контроля (n=532, средний возраст 56,1 лет, мужчины - 33,8%, женщины - 66,2%) сформированы из банка ДНК международного исследования HAPIEE. ДНК выделена методом фенолхлороформной экстракции. Генотипирование выполнено методом ПЦР с последующим анализом полиморфизма длин рестрикционных фрагментов. Статистическая обработка проведена с использованием программного пакета SPSS 16.0. По частотам генотипов и аллелей полиморфизмов rs2237892 гена KCNQ1 и rs6773957 гена ADIPOQ не выявлено статистически значимых различий между группами, в том числе и при разделении по полу и возрасту (p>0,05). Значимого влияния rs2237892 гена KCNQ1 и rs6773957 гена ADIPOQ на риск развития СД2 не обнаружено. The aim of this work is study the association of rs2237892 and rs6773957 with T2D in a case-control study. Two groups was formed based on the case - control study. The T2D group is 443 person (mean age 56.2 years, men - 28.8 %, women - 66.2 %), the control group was selected according to the sex and age from the DNA bank of project Health, Alcohol and Psychosocial factors In Eastern Europe (HAPIEE) (n = 532, mean age 56.1 years, men - 33.8 %, women - 66.2 %). DNA was isolated by phenol-chloroform extraction. Genotyping was done by PCR followed by analysis of restriction fragment length polymorphism. Statistical processing was performed using the SPSS 16.0 software package. The genotypes frequencies of rs2237892 of the KCNQ1 gene and rs6773957 of the ADIPOQ gene did not show statistically significant differences. There was no significant effect of rs2237892 of the KCNQ1 gene and rs6773957 of the ADIPOQ gene on the risk of developing type 2 diabetes.

scholarly journals Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case–control study in Han Chinese

2012 ◽  
Vol 57 (5) ◽  
pp. 320-325 ◽  
Author(s):  
Feng Lu ◽  
Yun Qian ◽  
Huizhang Li ◽  
Meihua Dong ◽  
Yudi Lin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Diabetes Risk ◽  
Control Study

Corrigendum to: Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian Population: A Case-Control Study

2021 ◽  
Vol 21 (7) ◽  
pp. 1375-1375
Author(s):  
Amin Bakhtiyari ◽  
Karimeh Haghani ◽  
Salar Bakhtiyari ◽  
Mohammad A. Zaimy ◽  
Nooriali Zahed ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Diabetes Risk ◽  
Iranian Population ◽  
Control Study

Due to oversight on the part of the authors, the names of two of the co-authors have been incorrectly published in the article entitled, “Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian Population: A Case-Control Study”, 2021, Vol. 21, No. 3, pp. 441-447 [1]. The original article can be found online at: https://doi.org/10.2174/1871530320666200713091827. Original: Amin Bakhtiyari, Karimeh Haghani, Salar Bakhtiyari*, Mohammad A. Zaimy, Nooriali Zahed, Ali Gheysarzadeh, Shahram Darabi, Seidali Nahalkhani, Mansour Amraei and Iraj Alipourfard Corrected: Amin Bakhtiyari, Karimeh Haghani, Salar Bakhtiyari*, Mohammad A. Zaimy, Ali Noori-Zadeh, Ali Gheysarzadeh, Shahram Darabi, Ali Seidkhani-Nahal, Mansour Amraei and Iraj Alipourfard

Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case–control study of Chinese Han population

Endocrine ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 413-422 ◽  
Author(s):  
Wencong Du ◽  
Qian Li ◽  
Ying Lu ◽  
Xiaofang Yu ◽  
Xinhua Ye ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Adipoq Gene ◽  
Control Study
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