scholarly journals A theoretical study to establish the relationship between the three-dimensional structure of triose-phosphate isomerase of Giardia duodenalis and point mutations in the respective gene

2010 ◽  
Vol 24 (5) ◽  
pp. 281-285 ◽  
Author(s):  
Matthew J. Nolan ◽  
Andreas Hofmann ◽  
Aaron R. Jex ◽  
Robin B. Gasser
Keyword(s):  
Theoretical Study ◽  
Three Dimensional ◽  
Point Mutations ◽  
Giardia Duodenalis ◽  
Triose Phosphate Isomerase ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Triose Phosphate ◽  
The Relationship

An Analysis of the Three-Dimensional Structure of Chicken Triose Phosphate Isomerase

1977 ◽  
Vol 5 (3) ◽  
pp. 642-647 ◽  
Author(s):  
D. C. PHILLIPS ◽  
P. S. RIVERS ◽  
M. J. E. STERNBERG ◽  
J. M. THORNTON ◽  
I. A. WILSON
Keyword(s):  
Three Dimensional ◽  
Triose Phosphate Isomerase ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Triose Phosphate

On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase

1981 ◽  
Vol 293 (1063) ◽  
pp. 159-171 ◽  
Keyword(s):  
Catalytic Mechanism ◽  
Polypeptide Chain ◽  
Three Dimensional ◽  
Triose Phosphate Isomerase ◽  
Dimensional Structure ◽  
Dihydroxyacetone Phosphate ◽  
Triose Phosphate ◽  
Independent Determination ◽  
Chicken Muscle

Triose phosphate isomerase is a dimeric enzyme of molecular mass 56000 which catalyses the interconversion of dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate. The crystal structure of the enzyme from chicken muscle has been determined at a resolution of 2.5 A, and an independent determination of the structure of the yeast enzyme has just been completed at 3 A resolution. The conformation of the polypeptide chain is essentially identical in the two structures, and consists of an inner cylinder of eight strands of parallel |3-pleated sheet, with mostly helical segments connecting each strand. The active site is a pocket containing glutamic acid 165, which is believed to act as a base in the reaction. Crystallographic studies of the binding of DHAP to both the chicken and the yeast enzymes reveal a common mode of binding and suggest a mechanism for catalysis involving polarization of the substrate carbonyl group.

Three-Dimensional Structure of a Huadian Oil Shale Kerogen Model: An Experimental and Theoretical Study

2015 ◽  
Vol 29 (7) ◽  
pp. 4122-4136 ◽  
Author(s):  
Xiao-Hui Guan ◽  
Yao Liu ◽  
Di Wang ◽  
Qing Wang ◽  
Ming-Shu Chi ◽  
...  
Keyword(s):  
Oil Shale ◽  
Theoretical Study ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Three Dimensional Structure

scholarly journals Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme

Blood ◽  
1996 ◽  
Vol 87 (7) ◽  
pp. 2974-2982 ◽  
Author(s):  
CE Naylor ◽  
P Rowland ◽  
AK Basak ◽  
S Gover ◽  
PJ Mason ◽  
...  
Keyword(s):  
Tertiary Structure ◽  
Clinical Symptoms ◽  
Enzyme Stability ◽  
Three Dimensional ◽  
Point Mutations ◽  
Clinical Manifestations ◽  
Enzyme Deficiency ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Glucose 6 Phosphate Dehydrogenase

Human glucose 6-phosphate dehydrogenase (G6PD) has a particularly large number of variants resulting from point mutations; some 60 mutations have been sequenced to date. Many variants, some polymorphic, are associated with enzyme deficiency. Certain variants have severe clinical manifestations; for such variants, the mutant enzyme almost always displays a reduced thermal stability. A homology model of human G6PD has been built, based on the three-dimensional structure of the enzyme from Leuconostoc mesenteroides. The model has suggested structural reasons for the diminished enzyme stability and hence for deficiency. It has shown that a cluster of mutations in exon 10, resulting in severe clinical symptoms, occurs at or near the dimer interface of the enzyme, that the eight-residue deletion in the variant Nara is at a surface loop, and that the two mutations in the A- variant are close together in the three-dimensional structure.

scholarly journals Heavy rain and strong wind events and cyclones in the Balearics

2006 ◽  
Vol 7 ◽  
pp. 73-77 ◽  
Author(s):  
J. Campins ◽  
A. Jansà ◽  
A. Genovés
Keyword(s):  
Three Dimensional ◽  
Geographical Location ◽  
Heavy Rain ◽  
Balearic Islands ◽  
Dimensional Structure ◽  
Strong Wind ◽  
Affected Area ◽  
Three Dimensional Structure ◽  
Wind Events ◽  
The Relationship

Abstract. The relationship between heavy rain (HR) and/or strong wind (SW) events and cyclones is investigated for the Balearic Islands. First, a list of HR and SW events is cross-referenced with an objective cyclone database for a 9-year period (from June 1995 to May 2004). The presence of a cyclone centre close to the Balearics is looked for each event. For HR events in most of the cases a cyclone centre is located in the vicinity. Furthermore, cyclones are located in such a way that allow the supply of warm and wet air to the affected area. But for SW events, although in the majority of cases a cyclone centre is detected, cyclones are located farther than for HR events and their geographical location is more widespread. Afterwards, the three-dimensional structure of cyclones related to HR and/or SW events is studied in detail.

Modeling the impact of point mutations on the stability of proteins

2020 ◽  
Vol 18 (04) ◽  
pp. 2050019
Author(s):  
K. G. Kulikov ◽  
T. V. Koshlan
Keyword(s):  
Protein Interactions ◽  
Protein Complexes ◽  
Three Dimensional ◽  
Point Mutations ◽  
Dimensional Structure ◽  
Amino Acid Residues ◽  
Three Dimensional Structure ◽  
The Stability ◽  
The Impact ◽  
Proven Theorem

A new method has been introduced which allows us to determine the stability of protein complexes with point changes of amino acid residues that also take into account the three-dimensional structure of the complex. This formulated and proven theorem is aimed at determining the criterion for the stability of protein molecules. The algorithm and software package were developed for analyzing protein interactions, taking into account their three-dimensional structure from the PDB database.

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