Aerospace applications require special procedures for component design and manufacturing. Spur gears of different designs, because of their simpler geometries, are used in vital units-transmissions of helicopters and alike aerospace vehicles. In this study, performances of various profile designs of previously researched low and high contact ratio spur gears with some realistic design parameters are studied. Effects of the realistic parameters of variable tooth pair stiffness, relief shape, and adjacent pitch error on Transmission Error (TE), tooth loads and root stresses are presented; composition of these parameters determines the efficiency of the gearbox assembly. Detail of minimization of tooth root stress through optimized/proper design of relief is described. More comprehensive comparison of the gear tooth profile design cases is done to be able to guide aerospace transmission designers for practical applications with realistic parameters for each of the design cases. A preference order is done among the design cases, depending on effect of some design parameters on the results such as tooth loads, tooth root stresses, TE curves and peak-to-peak TE values.