Regional and Distant Metastasis of Oral Squamous Cell Carcinoma in a Male Castrated Llama: A Case Report

A 19-year-old male castrated llama presented with a 3-year history of tooth root abscesses and an osseous mass on the left mandible. Surgical excision of the affected teeth and mass was performed, and histopathologic review indicated that the mass was an oral squamous cell carcinoma. The patient was admitted to the hospital again 4 months later in severe respiratory distress with submandibular edema, and bicavitary effusion. Necropsy results revealed regional and distant metastatic squamous cell carcinoma.

In-depth analysis of crack area characteristics of fisheye failures influenced by the multiaxial stress condition in the tooth root fillet of high-strength gears

Modern high-strength gears have to satisfy many requirements, such as improved tooth root bending strength. The process of shot-peening is correlated to the introduction of compressive residual stresses in the surface layer of a gear to achieve a higher tooth root bending strength. However, due to the compressive residual stresses fisheye failures can occur and can have a determining effect on the endurance of high-strength gears. By preventing such failures, it should be possible to increase further the tooth root bending strength of high-strength gears. However, this requires a deeper understanding of the crack initiation and propagation processes. Especially the unique multiaxial stress condition in the tooth root fillet of a gear could influence the crack area characteristics significantly. Though, in the literature there is no proper characterization of crack area characteristics in the tooth root fillet of gears in detail, so far. Furthermore, in previous work a model approach for the evaluation of the tooth root bending strength of gears was presented, which is based on the results of Murakami. A first comparison with experimental data showed a basic applicability of the model approach on gears. However, the derived model approach showed some room for improvement. Questions arose as to whether the approach is really fully applicable to gears, whether further modifications are needed, or whether further extension is even practical, since the fisheye fracture characteristics of gears might differ significantly from those of standard specimens. The aim of this paper is therefore to present an extensive in-depth analysis of the crack area characteristics in the event of tooth root fracture damages caused by a fisheye failure in high-strength gears. Furthermore, a case study is used to verify whether a detailed evaluation of the characteristics of non-metallic inclusions leads to more accurate results of the model approach.

Precise mathematical model for the ratchet tooth root bending stress

A ratchet is an essential component of the ratchet pawl mechanism. But the traditional ratchet strength check method has certain limitations in the design process. In this paper, the stress analysis of the ratchet is discussed and a precision mathematical model for the ratchet tooth root bending stress is proposed for the first time. This model was established by the folded section and defined by the incision effect theory. To test the prediction ability of the proposed mathematical model, the maximum stress of three standard ratchets and one non-standard ratchet were analyzed by the FEA (finite element analysis) method. The non-standard ratchet was adapted in the ratchet experiment to analyze its maximum stress. The analysis results presented in this paper show that the proposed mathematical model has a good predictability, regardless of whether it is a standard or non-standard ratchet. It is recommended that this model can be used to predict the ratchet tooth root bending stress in the ratchet design process.

Reconstructing the childhood diet of individuals buried with the Pictish monastic community at Portmahomack

This research aims to reconstruct the childhood diets (aged 9–10 years) of the individuals buried during the active years of the Pictish monastic community (hereafter referred to as PMC) from early medieval (7th–11th century) Portmahomack in north-east Scotland, using 13C and 15N isotopes. Dietary reconstructions were achieved by isotope analysis of δ13C and δ15N on the tooth root apex from permanent first molars (M1) of 26 adult male individuals. The results indicate that the indi-viduals in PMC predominantly consumed terrestrial C3 resources during childhood, with a rich terrestrial protein diet and some marine resource consumption. Statistically significant differences were observed between childhood and adulthood diets (the latter derived from previous research), suggesting that when these individuals were children, they consumed more marine protein than in later years as adults. This is true for all individuals, whether or not they spent significant time in Portmahomack during their childhoods. This is the most extensive study of the childhood diet of in-dividuals from the PMC and so makes a significant contribution to augmenting information on diet and lifestyles in Pictish Scotland.

The Role of Wnt Signaling in Postnatal Tooth Root Development

Appropriate tooth root formation and tooth eruption are critical for achieving and maintaining good oral health and quality of life. Tooth eruption is the process through which teeth emerge from their intraosseous position to their functional position in the oral cavity. This temporospatial process occurs simultaneously with tooth root formation through a cascade of interactions between the epithelial and adjoining mesenchymal cells. Here, we will review the role of the Wnt system in postnatal tooth root development. This signaling pathway orchestrates the process of tooth root formation and tooth eruption in conjunction with several other major signaling pathways. The Wnt signaling pathway is comprised of the canonical, or Wnt/β-catenin, and the non-Canonical signaling pathway. The expression of multiple Wnt ligands and their downstream transcription factors including β-catenin is found in the cells in the epithelia and mesenchyme starting from the initiation stage of tooth development. The inhibition of canonical Wnt signaling in an early stage arrests odontogenesis. Wnt transcription factors continue to be present in dental follicle cells, the progenitor cells responsible for differentiation into cells constituting the tooth root and the periodontal tissue apparatus. This expression occurs concurrently with osteogenesis and cementogenesis. The conditional ablation of β-catenin in osteoblast and odontoblast causes the malformation of the root dentin and cementum. On the contrary, the overexpression of β-catenin led to shorter molar roots with thin and hypo-mineralized dentin, along with the failure of tooth eruption. Therefore, the proper expression of Wnt signaling during dental development is crucial for regulating the proliferation, differentiation, as well as epithelial-mesenchymal interaction essential for tooth root formation and tooth eruption.