Femoroplasty – augmentation of the proximal femur with a composite bone cement – feasibility, biomechanical properties and osteosynthesis potential

Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature, and the monomer has certain toxicity. Our study tried to modify the PMMA bone cement by doping with various particle weight fractions (5, 10 and 15%) of SCPP particles and polydopamine-coated SCPP particles (D/SCPP) to overcome its clinical application disadvantages. Our study showed that all results of physical properties of samples are in accordance with ISO 5833. The 15% D/SCPP/PMMA composite bone cement had much better biocompatibility compared with pure PMMA bone cement and SCPP/PMMA composite bone cement due to the best cell growth-promoting mineralization deposition on the surface of 15% D/SCPP/PMMA composite bone cements and Sr 2+ released from SCPP particles. Our research also revealed that the reaction temperature was found to be reduced with an increase in doped particles after incorporating the particles into composite bone cements. The novel PMMA bone cements modified by D/SCPP particles are promising materials for bone repair.

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Development of a New Composite Bone Cement as a Bone Substitute for Vertebroplasty

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.309-311.805 ◽

2006 ◽

Vol 309-311 ◽

pp. 805-808 ◽

Cited By ~ 1

Author(s):

Koji Goto ◽

Shunsuke Fujibayashi ◽

Jiro Tamura ◽

Keiichi Kawanabe ◽

Shin Hasegawa ◽

...

Keyword(s):

Electron Microscopy ◽

Scanning Electron Microscopy ◽

Bone Cement ◽

Bone Contact ◽

Beta Tricalcium Phosphate ◽

Surface Staining ◽

Contact Microradiography ◽

Urethane Dimethacrylate ◽

Scanning Electron ◽

Composite Bone

A new composite bone cement designated ‘G2B1’ was developed for percutaneous transpedicular vertebroplasty. G2B1 contains beta tricalcium phosphate particles and methylmethacrylate –methylacrylate copolymer as the powder components, and methylmethacrylate, urethane dimethacrylate, and tetrahydrofurfuryl methacrylate as the liquid components. Osteoconductivity and histological changes with time were evaluated using scanning electron microscopy, contact microradiography, and Giemsa surface staining 4, 8, 12, 26, and 52 weeks after implantation into rat tibiae. To evaluate osteoconductivity, affinity indices (%) were calculated. Scanning electron microscopy and contact microradiography revealed that bone contact with G2B1 was attained within 4 weeks (affinity index: 50.2 ± 11.8 at 4 weeks) and at most of the margin within 26 weeks (affinity index: 87.4 ± 7.2 at 26 weeks). Giemsa surface staining showed that there was almost no inflammatory reaction around the G2B1. These results indicate that G2B1 is a biocompatible and highly osteoconductive bone cement.

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