Computational identification of interplay between phosphorylation and O-β-glycosylation of human occludin as potential mechanism to impair hepatitis C virus entry

2012 ◽  
Vol 12 (6) ◽  
pp. 1235-1245 ◽  
Author(s):  
Azeem Mehmood Butt ◽  
Dandan Feng ◽  
Izza Nasrullah ◽  
Shifa Tahir ◽  
Muhammad Idrees ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Potential Mechanism ◽  
Computational Identification

scholarly journals Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0154498 ◽  
Author(s):  
Aarti Ramanathan ◽  
Viktoria Gusarova ◽  
Neil Stahl ◽  
Anne Gurnett-Bander ◽  
Christos A. Kyratsous
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Human Antibody

scholarly journals Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments

2017 ◽  
Vol 114 (23) ◽  
pp. E4527-E4529 ◽  
Author(s):  
Hirofumi Ohashi ◽  
Yoshiki Koizumi ◽  
Kento Fukano ◽  
Takaji Wakita ◽  
Alan S. Perelson ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Direct Acting Antiviral ◽  
Entry Inhibitors ◽  
Virus Entry Inhibitors ◽  
Direct Acting

scholarly journals Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers

BMC Genomics ◽  
2009 ◽  
Vol 10 (1) ◽  
pp. 373 ◽  
Author(s):  
Xinxia Peng ◽  
Yu Li ◽  
Kathie-Anne Walters ◽  
Elizabeth R Rosenzweig ◽  
Sharon L Lederer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Regulatory Modules ◽  
Computational Identification ◽  
Human Livers

scholarly journals A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry

2010 ◽  
Vol 6 (9) ◽  
pp. e1001086 ◽  
Author(s):  
Carl J. Baldick ◽  
Michael J. Wichroski ◽  
Annapurna Pendri ◽  
Ann W. Walsh ◽  
Jie Fang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Small Molecule ◽  
Virus Entry ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor

scholarly journals Hepatitis C virus entry into the hepatocyte

2011 ◽  
Vol 6 (6) ◽  
pp. 933-945 ◽  
Author(s):  
Sandrine Belouzard ◽  
Laurence Cocquerel ◽  
Jean Dubuisson
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Current Knowledge ◽  
Virus Entry ◽  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Surface Proteins ◽  
Enveloped Virus ◽  
Early Endosomes

AbstractHepatitis C virus (HCV) is a small enveloped virus with a positive stranded RNA genome belonging to the Flaviviridae family. The virion has the unique ability of forming a complex with lipoproteins, which is known as the lipoviroparticle. Lipoprotein components as well as the envelope proteins, E1 and E2, play a key role in virus entry into the hepatocyte. HCV entry is a complex multistep process involving sequential interactions with several cell surface proteins. The virus relies on glycosaminoglycans and possibly the low-density lipoprotein receptors to attach to cells. Furthermore, four specific entry factors are involved in the following steps which lead to virus internalization and fusion in early endosomes. These molecules are the scavenger receptor SRB1, tetraspanin CD81 and two tight junction proteins, Claudin-1 and Occludin. Although they are essential to HCV entry, the precise role of these molecules is not completely understood. Finally, hepatocytes are highly polarized cells and which likely affects the entry process. Our current knowledge on HCV entry is summarized in this review.

scholarly journals The ins and outs of hepatitis C virus entry and assembly

2013 ◽  
Vol 11 (10) ◽  
pp. 688-700 ◽  
Author(s):  
Brett D. Lindenbach ◽  
Charles M. Rice
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry
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