scholarly journals Mice immunization with Trypanosoma brucei gambiense translationally controlled tumor protein modulates immunoglobulin and cytokine production, as well as parasitaemia and mice survival after challenge with the parasite

2020 ◽  
pp. 104636
Author(s):  
Géraldine Bossard ◽  
Valérie Rodrigues ◽  
Eleonore Tour ◽  
Anne Geiger
Keyword(s):  
Trypanosoma Brucei ◽  
Cytokine Production ◽  
Translationally Controlled Tumor Protein ◽  
Trypanosoma Brucei Gambiense

scholarly journals Characterization of recombinant Trypanosoma brucei gambiense Translationally Controlled Tumor Protein (rTbgTCTP) and its interaction with Glossina midgut bacteria

Gut Microbes ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 413-427 ◽  
Author(s):  
Géraldine Bossard ◽  
Manon Bartoli ◽  
Marie-Laure Fardeau ◽  
Philippe Holzmuller ◽  
Bernard Ollivier ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Translationally Controlled Tumor Protein ◽  
Trypanosoma Brucei Gambiense

scholarly journals The Trypanosoma brucei gambiense Secretome Impairs Lipopolysaccharide-Induced Maturation, Cytokine Production, and Allostimulatory Capacity of Dendritic Cells

2013 ◽  
Vol 81 (9) ◽  
pp. 3300-3308 ◽  
Author(s):  
Edwin Garzón ◽  
Philippe Holzmuller ◽  
Rachel Bras-Gonçalves ◽  
Philippe Vincendeau ◽  
Gérard Cuny ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Trypanosoma Brucei ◽  
Cytokine Production ◽  
Interleukin 10 ◽  
Host Immune System ◽  
Necrosis Factor Alpha ◽  
Content Type ◽  
Host Immune Responses ◽  
Trypanosoma Brucei Gambiense ◽  
Factor Alpha

ABSTRACTTrypanosoma brucei gambiense, a parasitic protozoan belonging to kinetoplastids, is the main etiological agent of human African trypanosomiasis (HAT), or sleeping sickness. One major characteristic of this disease is the dysregulation of the host immune system. The present study demonstrates that the secretome (excreted-secreted proteins) ofT. b. gambienseimpairs the lipopolysaccharide (LPS)-induced maturation of murine dendritic cells (DCs). The upregulation of major histocompatibility complex class II, CD40, CD80, and CD86 molecules, as well as the secretion of cytokines such as tumor necrosis factor alpha, interleukin-10 (IL-10), and IL-6, which are normally released at high levels by LPS-stimulated DCs, is significantly reduced when these cells are cultured in the presence of theT. b. gambiensesecretome. Moreover, the inhibition of DC maturation results in the loss of their allostimulatory capacity, leading to a dramatic decrease in Th1/Th2 cytokine production by cocultured lymphocytes. These results provide new insights into a novel efficient immunosuppressive mechanism directly involving the alteration of DC function which might be used byT. b. gambienseto interfere with the host immune responses in HAT and promote the infectious process.

scholarly journals Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

2013 ◽  
Vol 7 (10) ◽  
pp. e2475 ◽  
Author(s):  
Fabrice E. Graf ◽  
Philipp Ludin ◽  
Tanja Wenzler ◽  
Marcel Kaiser ◽  
Reto Brun ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Field Isolates ◽  
Trypanosoma Brucei Gambiense ◽  
Aquaporin 2

Cyclical transmission of Trypanosoma brucei gambiense in Glossina palpalis gambiensis displays great differences among field isolates

Acta Tropica ◽  
2006 ◽  
Vol 100 (1-2) ◽  
pp. 151-155 ◽  
Author(s):  
S. Ravel ◽  
D. Patrel ◽  
M. Koffi ◽  
V. Jamonneau ◽  
G. Cuny
Keyword(s):  
Trypanosoma Brucei ◽  
Field Isolates ◽  
Glossina Palpalis Gambiensis ◽  
Trypanosoma Brucei Gambiense ◽  
Glossina Palpalis ◽  
Cyclical Transmission

scholarly journals Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense

2015 ◽  
Vol 6 ◽  
pp. 1-9 ◽  
Author(s):  
Natalia Tiberti ◽  
Veerle Lejon ◽  
Dieudonné Mumba Ngoyi ◽  
Enock Matovu ◽  
John Enyaru ◽  
...  
Keyword(s):  
Immune Response ◽  
Trypanosoma Brucei ◽  
Sleeping Sickness ◽  
Trypanosoma Brucei Rhodesiense ◽  
Trypanosoma Brucei Gambiense

scholarly journals Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal

2012 ◽  
Vol 6 (6) ◽  
pp. e1691 ◽  
Author(s):  
Vincent Jamonneau ◽  
Hamidou Ilboudo ◽  
Jacques Kaboré ◽  
Dramane Kaba ◽  
Mathurin Koffi ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Brucei Gambiense ◽  
Human Infections

scholarly journals IL-2 production inhibitory activity of the sera in trypanosoma brucei gambiense infected mice.

1989 ◽  
Vol 17 (1) ◽  
pp. 9-15
Author(s):  
DAO TAO ◽  
MINORU HIGASA ◽  
HIKOSHIRO MIYAMOTO ◽  
KAZUHIKO YAMADA ◽  
TOSHINORI KOMATSU ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Inhibitory Activity ◽  
Trypanosoma Brucei Gambiense
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