Neuroprotective and neuro-survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and mitochondrial uncoupling protein −2(UCP-2)

2020 ◽  
Vol 143 ◽  
pp. 110094
Author(s):  
Afrah Sepehr ◽  
Fereshteh Taheri ◽  
Sara Heidarian ◽  
Majid Motaghinejad ◽  
Sepideh Safari
Keyword(s):  
Signaling Pathway ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Mitochondrial Uncoupling ◽  
Mitochondrial Uncoupling Protein

scholarly journals Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine

2012 ◽  
Vol 1823 (10) ◽  
pp. 1856-1863 ◽  
Author(s):  
Elisa Dalla Pozza ◽  
Claudia Fiorini ◽  
Ilaria Dando ◽  
Marta Menegazzi ◽  
Anna Sgarbossa ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Cell Resistance ◽  
Mitochondrial Uncoupling ◽  
Mitochondrial Uncoupling Protein

scholarly journals Mitochondrial Uncoupling protein‐2 regulates NLRP3 inflammasome

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Rajan babu Venugopal ◽  
Ruan Rollin Cox ◽  
prasanna Tamarappu Parthasarathy ◽  
Richard F Lockey ◽  
Narasaiah Kolliputi
Keyword(s):  
Nlrp3 Inflammasome ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Mitochondrial Uncoupling ◽  
Mitochondrial Uncoupling Protein

scholarly journals Neuroprotective Role of Mitochondrial Uncoupling Protein 2 in Cerebral Stroke

2009 ◽  
Vol 29 (6) ◽  
pp. 1069-1078 ◽  
Author(s):  
Suresh L Mehta ◽  
P. Andy Li
Keyword(s):  
Uncoupling Protein ◽  
Cellular Damage ◽  
Cerebral Stroke ◽  
Inner Mitochondrial Membrane ◽  
Mitochondrial Uncoupling ◽  
Mitochondria Membrane Potential ◽  
Mitochondrial Uncoupling Protein ◽  
Mitochondrial Transporter ◽  
Develop Strategy

The uncoupling proteins (UCPs) are mitochondrial transporter proteins involved in proton conductance across inner mitochondrial membrane (IMM). UCP2, which is one of the members of this class of proteins, has a wide but restricted tissue distribution including brain. Its physiologic role according to emerging evidences, although still not clear, indicate that distribution of UCP2 may be related to regulation of mitochondria membrane potential (ΔΨm), production of reactive oxygen species (ROS), preservation of calcium homeostasis, modulation of neuronal activity, and eventually inhibition of cellular damage. These factors are very important in determining the fate of neurons and damage progression in the brain during various neurodegenerative diseases including cerebral stroke. Recent evidence indicates that an increased expression and activity of UCP2 are well correlated with neuronal survival after stroke and trauma. This review briefly covers the present understanding of UCP2, which eventually may be beneficial to understand the precise role of UCP2 to develop strategy to identify its potential therapeutic application.

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