Can music restore brain connectivity in post-stroke cognitive deficits?

2022 ◽  
pp. 110761
Author(s):  
Paolo Bartolomeo
2021 ◽  
pp. 174749302098455
Author(s):  
Nick A Weaver ◽  
Angelina K Kancheva ◽  
Jae-Sung Lim ◽  
J Matthijs Biesbroek ◽  
Irene MC Huenges Wajer ◽  
...  

Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (<5th percentile; normative data) and infarct location in 1198 patients (age 67 ± 12 years, 43% female) with acute ischemic stroke using voxel-based lesion-symptom mapping. As a frame of reference, infarct patterns associated with impairments in individual cognitive domains were determined, based on a more detailed neuropsychological assessment. Results Impairment on the MMSE was present in 420 patients (35%). Large voxel clusters in the left middle cerebral artery territory and thalamus were significantly (p < 0.01) associated with cognitive impairment on the MMSE, with highest odds ratios (>15) in the thalamus and superior temporal gyrus. In comparison, domain-specific impairments were related to various infarct patterns across both hemispheres including the left medial temporal lobe (verbal memory) and right parietal lobe (visuospatial functioning). Conclusions Our findings indicate that post-stroke cognitive impairment on the MMSE primarily relates to infarct locations in the left middle cerebral artery territory. The MMSE is apparently less sensitive to cognitive deficits that specifically relate to other locations.


2021 ◽  
Vol 11 (1) ◽  
pp. 53
Author(s):  
Sara Kierońska ◽  
Milena Świtońska ◽  
Grzegorz Meder ◽  
Magdalena Piotrowska ◽  
Paweł Sokal

Fiber tractography based on diffuse tensor imaging (DTI) can reveal three-dimensional white matter connectivity of the human brain. Tractography is a non-invasive method of visualizing cerebral white matter structures in vivo, including neural pathways surrounding the ischemic area. DTI may be useful for elucidating alterations in brain connectivity resulting from neuroplasticity after stroke. We present a case of a male patient who developed significant mixed aphasia following ischemic stroke. The patient had been treated by mechanical thrombectomy followed by an early rehabilitation, in conjunction with transcranial direct current stimulation (tDCS). DTI was used to examine the arcuate fasciculus and uncinate fasciculus upon admission and again at three months post-stroke. Results showed an improvement in the patient’s symptoms of aphasia, which was associated with changes in the volume and numbers of tracts in the uncinate fasciculus and the arcuate fasciculus.


2014 ◽  
Vol 94 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Emma Schleiger ◽  
Nabeel Sheikh ◽  
Tennille Rowland ◽  
Andrew Wong ◽  
Stephen Read ◽  
...  

2020 ◽  
pp. 465-500
Author(s):  
Marcelo L. Berthier ◽  
Guadalupe Dávila ◽  
Lisa Edelkraut ◽  
Diana López-Barroso ◽  
María José Torres-Prioris ◽  
...  

The purpose of the study was to assess the prevalence of post-stroke pain and the effectiveness of its diagnosis and treatment in the conditions of university clinic. It was shown that the frequency of post-stroke pain syndrome is 55.8% of the total number of patients with PPS. The pain in the shoulder joint of the paretic limb is most often recorded, due to the subluxation of the humerus, which is recorded in 28.3% of patients with PPS during hospital stay and 20.3% in the first weeks after discharge. The frequency of PPS of the central genesis is 31.1%. Syndrome of complex regional pain occurs in 4.4% of patients, pain associated with spasticity – in 13.0%. The use of visual analog scales makes it possible to diagnose post-stroke pain syndrome in patients who are conscious and have no significant cognitive deficits. With the application of complex treatment of pain syndrome, a satisfactory clinical effect is achieved in all patients, and the best response to treatment was in patients with pain in the shoulder joint of the paretic limb due to the subluxation of the head of the humerus.


2020 ◽  
Vol 41 (6) ◽  
pp. 1387-1399 ◽  
Author(s):  
Christoph Sperber ◽  
Chloé Nolingberg ◽  
Hans‐Otto Karnath

2003 ◽  
Vol 42 (05) ◽  
pp. 519-523 ◽  
Author(s):  
G. C. Burdea

Summary Objectives: To discuss the advantages and disadvantages of rehabilitation applications of virtual reality. Methods: VR can be used as an enhancement to conventional therapy for patients with conditions ranging from musculo-skeletal problems, to stroke-induced paralysis, to cognitive deficits. This approach is called “VR-augmented rehabilitation.” Alternately, VR can replace conventional interventions altogether, in which case the rehabilitation is “VR-based.” If the intervention is done at a distance, then it is called “telerehabilitation.” Simulation exercises for post-stroke patients have been developed using a “teacher object” approach or a video game approach. Simulations for musculo-skeletal patients use virtual replicas of rehabilitation devices (such as rubber ball, power putty, peg board). Phobia-inducing virtual environments are prescribed for patients with cognitive deficits. Results: VR-augmented rehabilitation has been shown effective for stroke patients in the chronic phase of the disease. VR-based rehabilitation has been improving patients with fear of flying, Vietnam syndrome, fear of heights, and chronic stroke patients. Telerehabilitation interventions using VR have improved musculo-skeletal and post-stroke patients, however less data is available at this time. Conclusions: Virtual reality presents significant advantages when applied to rehabilitation of patients with varied conditions. These advantages include patient motivation, adaptability and variability based on patient baseline, transparent data storage, online remote data access, economy of scale, reduced medical costs. Challenges in VR use for rehabilitation relate to lack of computer skills on the part of therapists, lack of support infrastructure, expensive equipment (initially), inadequate communication infrastructure (for telerehabilitation in rural areas), and patient safety concerns.


1999 ◽  
Vol 33 (4) ◽  
pp. 598-600 ◽  
Author(s):  
David Fenn ◽  
Kuruvilla George

Objective: Although post-stroke depression is well recognised, post-stroke mania has rarely been reported and researched. Most reported cases have involved lesions of the non-dominant hemisphere. We report a case of late-onset mania following stroke with a lesion in the dominant hemisphere. Clinical picture: A 78-year-old, right-handed man developed sudden cognitive deficits and manic symptoms. Investigations revealed lesions in the dominant hemisphere. Treatment: Pharmacological intervention was complicated by side effects. Outcome: His symptoms resolved gradually over 2 months and he was back to normal in 4 months. Conclusions: We would encourage further study in the area of post-stroke mania and especially in relation to the site of the lesion in the brain.


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