In vitro investigation of potential application of pH-sensitive poly(vinylidene fluoride)–poly(acrylic acid) pore-filled membranes for controlled drug release in ruminant animals

2009 ◽  
Vol 337 (1-2) ◽  
pp. 9-16 ◽  
Author(s):  
Kang Hu ◽  
James M. Dickson
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Potential Application ◽  
Vinylidene Fluoride ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
In Vitro Investigation ◽  
Poly Vinylidene Fluoride ◽  
Ruminant Animals

Drug release from poly(acrylic acid) grafted poly(vinylidene fluoride) membrane bags in the gastrointestinal tract in the rat and dog

2000 ◽  
Vol 66 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Tommy Tarvainen ◽  
Timo Nevalainen ◽  
Annika Sundell ◽  
Bror Svarfvar ◽  
Johanna Hyrsylä ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Drug Release ◽  
Acrylic Acid ◽  
Vinylidene Fluoride ◽  
Poly Vinylidene Fluoride ◽  
Poly Acrylic Acid

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

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