Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

Author(s):  
Zahra Faraji Rad ◽  
Philip D. Prewett ◽  
Graham J. Davies
Author(s):  
Wande Zhang ◽  
Li-Hsin Han ◽  
Shaochen Chen

In this work, we demonstrate the plausibility of integrating two-photon polymerization (TPP) with nanoimprinting for direct, digital nanomanufacturing. TPP offers manufacturing of nanomolds at a low cost, while the nanoimprinting process using the nanomolds enables massively parallel printing of nanostructures. A Ti:sapphire femtosecond laser (800 nm wavelength, 100 fs pulse width, at a repetition rate of 80 MHz) was used to induce TPP in dipentaerythritol pentaacrylate to fabricate the nanoimprinting mold with 400 nm wide line array on a glass substrate. The mold surface was silanized by tridecafuoro-1,1,2,2-tetrahydrooctyl-1 trichlorosilane to facilitate the detachment of the mold from the imprinted material. This mold was then used to imprint poly(ethylene glycol) diacrylate (PEGDA). PEGDA is an important biomaterial for many applications such as tissue scaffolds for cell growth. A spectrophotometer and a scanning electron microscope were used to characterize the materials and nanostructures.


2009 ◽  
Vol 1239 ◽  
Author(s):  
Shaun D. Gittard ◽  
Roger J Narayan ◽  
Aleksandr Ovsianikov ◽  
Boris N. Chichkov

AbstractOver the past twenty years, the use of rapid prototyping techniques for processing of medical devices has seen rapid growth. A number of rapid prototyping techniques currently exist for producing a broad range of medical devices using metals, ceramics, polymers, and composite materials. One promising rapid prototyping technology for creating medical devices with small scale features is two photon polymerization; this scalable photopolymerization technique enables processing of photosensitive materials such as organically-modified ceramic materials. In this study, two photon polymerization was used to produce microneedles that mimic the anatomy of the mosquito fascicle. The labrum of the mosquito was replicated in the mosquito-like microneedle. On the other hand, the maxillae of the mosquito were not replicated in the mosquito-like microneedle; the absence of these features was attributed to inadequate mechanical support of the maxillae. This study suggests that two photon polymerization and other rapid prototyping technologies may be used to produce biomimetic drug delivery devices that imitate the intricate structures found in nature.


Author(s):  
Andre Neumeister ◽  
Mark Boyle ◽  
Roman Kiyan ◽  
Johannes Zinn ◽  
Wendel Wohlleben ◽  
...  

2017 ◽  
Vol 68 (3) ◽  
pp. 453-458 ◽  
Author(s):  
Daniel Besnea ◽  
Alina Spanu ◽  
Iuliana Marlena Prodea ◽  
Gheorghita Tomescu ◽  
Iolanda Constanta Panait

The paper points out the advantages of rapid prototyping for improving the performances/constructive optimization of mixing devices used in process industries, here exemplified to propeller types ones. The multidisciplinary optimization of the propeller profile affords its design using parametric CAD methods. Starting from the mathematical curve equations proposed for the blade profile, it was determined its three-dimensional virtual model. The challenge has been focused on the variation of propeller pitch and external diameter. Three dimensional ranges were manufactured using the additive manufacturing process with Marker Boot 3D printer. The mixing performances were tested on the mixing equipment measuring the minimum rotational speed and the correspondent shaft torque for complete suspension achieved for each of the three models. The virtual and rapid prototyping method is newly proposed by the authors to obtain the basic data for scale up of the mixing systems, in the case of flexible production (of low quantities), in which both the nature and concentration of the constituents in the final product varies often. It is an efficient and low cost method for the rapid identification of the optimal mixing device configuration, which contributes to the costs reduction and to the growing of the output.


Author(s):  
Chandroth P. Jisha ◽  
Kuei-Chu Hsu ◽  
YuanYao Lin ◽  
Ja-Hon Lin ◽  
Chien-Chung Jeng ◽  
...  

Aerospace ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 74
Author(s):  
Alejandro Sobron ◽  
David Lundström ◽  
Petter Krus

Testing of untethered subscale models, often referred to as subscale flight testing, has traditionally had a relatively minor, yet relevant use in aeronautical research and development. As recent advances in electronics, rapid prototyping and unmanned-vehicle technologies expand its capabilities and lower its cost, this experimental method is seeing growing interest across academia and the industry. However, subscale models cannot meet all similarity conditions required for simulating full-scale flight. This leads to a variety of approaches to scaling and to other alternative applications. Through a literature review and analysis of different scaling strategies, this study presents an overall picture of how subscale flight testing has been used in recent years and synthesises its main issues and practical limitations. Results show that, while the estimation of full-scale characteristics is still an interesting application within certain flight conditions, subscale models are progressively taking a broader role as low-cost technology-testing platforms with relaxed similarity constraints. Different approaches to tackle the identified practical challenges, implemented both by the authors and by other organisations, are discussed and evaluated through flight experiments.


2020 ◽  
pp. 1-1
Author(s):  
Zhi-Yong Hu ◽  
Hang Ren ◽  
Hong Xia ◽  
Zhen-Nan Tian ◽  
Jin-Lei Qi ◽  
...  

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