The induction of Staphylococcus aureus biofilm formation or Small Colony Variants is a strain-specific response to host-generated chemical stresses

2015 ◽  
Vol 17 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Long M.G. Bui ◽  
John D. Turnidge ◽  
Stephen P. Kidd
Keyword(s):  
Staphylococcus Aureus ◽  
Biofilm Formation ◽  
Specific Response ◽  
Small Colony Variants ◽  
Small Colony

scholarly journals Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Haruna Adamu ◽  
Abdulrahman Kasim ◽  
Shitu Abdullahi ◽  
Patrick Shaibu
Keyword(s):  
Staphylococcus Aureus ◽  
Biofilm Formation ◽  
Small Colony Variants ◽  
Aureus Infection ◽  
Small Colony

scholarly journals Phenotypic Switching of Staphylococcus aureus Mu50 Into a Large Colony Variant Enhances Heritable Resistance Against β-Lactam Antibiotics

2021 ◽  
Vol 12 ◽  
Author(s):  
Yajun Sun ◽  
Miaomiao Liu ◽  
Mingze Niu ◽  
Xin Zhao
Keyword(s):  
Staphylococcus Aureus ◽  
Biofilm Formation ◽  
Bacterial Population ◽  
Protein A ◽  
Host Immunity ◽  
Phenotypic Switching ◽  
Small Colony Variants ◽  
Large Colony ◽  
Small Colony ◽  
Encoding Protein

Phenotypic heterogeneity within a bacterial population may confer new functionality and allow microorganisms to adapt to fluctuating environments. Previous work has suggested that Staphylococcus aureus could form small colony variants to avoid elimination by therapeutic antibiotics and host immunity systems. Here we show that a reversible non-pigment large colony morphology (Mu50∆lcpA-LC) was observed in S. aureus Mu50 after knocking out lcpA, coding for the LytR-CpsA-Psr family A protein. Mu50∆lcpA-LC increased resistance to β-lactam antibiotics, in addition, the enlarged cell size, enhanced spreading ability on solid medium, and reduced biofilm formation, suggesting better abilities for bacterial expansion. Moreover, the expression of spa encoding protein A was significantly increased in Mu50∆lcpA-LC. This study shows that besides the small colony variants, S. aureus could fight against antibiotics and host immunity through phenotype switching into a large colony variant.

Properties and control of cold-induced small colony variants of Staphylococcus aureus

2020 ◽  
pp. 100874
Author(s):  
Jiaju Qiao ◽  
Mengjiao Zhu ◽  
Yun Fan ◽  
Zhaoxin Lu ◽  
Fengxia Lv ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Small Colony Variants ◽  
Small Colony ◽  
And Control

scholarly journals Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide

2010 ◽  
Vol 10 (1) ◽  
pp. 33 ◽  
Author(s):  
Gabriel Mitchell ◽  
David Séguin ◽  
Ann-Elise Asselin ◽  
Eric Déziel ◽  
André M Cantin ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Small Colony Variants ◽  
Biofilm Production ◽  
Sigma B ◽  
Small Colony

Insights into the Emergence, Clinical Prevalence, and Significance of Staphylococcus aureus Small Colony Variants

2020 ◽  
pp. 189-211
Author(s):  
Derek E. Andreini ◽  
Christopher D. Bell ◽  
Malcolm Xing ◽  
Bingyun Li
Keyword(s):  
Staphylococcus Aureus ◽  
Small Colony Variants ◽  
Small Colony
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