CORR Insights®: Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Daniel Schlatterer
Keyword(s):  
Staphylococcus Aureus ◽  
Selective Pressure ◽  
Small Colony Variants ◽  
Small Colony

Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Robert Manasherob ◽  
Jake A. Mooney ◽  
David W. Lowenberg ◽  
Paul L. Bollyky ◽  
Derek F. Amanatullah
Keyword(s):  
Staphylococcus Aureus ◽  
Selective Pressure ◽  
Small Colony Variants ◽  
Small Colony

scholarly journals Evolution of Staphylococcus aureus under Vancomycin Selective Pressure: the Role of the Small-Colony Variant Phenotype

2014 ◽  
Vol 59 (2) ◽  
pp. 1347-1351 ◽  
Author(s):  
Justin R. Lenhard ◽  
Christof von Eiff ◽  
Irene S. Hong ◽  
Patricia N. Holden ◽  
Michael D. Bear ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Therapy ◽  
Selective Pressure ◽  
Type Model ◽  
Methicillin Resistant ◽  
Small Colony Variants ◽  
Content Type ◽  
Small Colony Variant ◽  
Small Colony

ABSTRACTStaphylococcus aureussmall-colony variants (SCVs) often persist despite antibiotic therapy. Against a 108-CFU/ml methicillin-resistantS. aureus(MRSA) (strain COL) population of which 0%, 1%, 10%, 50%, or 100% was an isogenichemBknockout (Ia48) subpopulation displaying the SCV phenotype, vancomycin achieved maximal reductions of 4.99, 5.39, 4.50, 3.28, and 1.66 log10CFU/ml over 48 h. Vancomycin at ≥16 mg/liter shifted a population from 50% SCV cells at 0 h to 100% SCV cells at 48 h, which was well characterized by a Hill-type model (R2> 0.90).

Properties and control of cold-induced small colony variants of Staphylococcus aureus

2020 ◽  
pp. 100874
Author(s):  
Jiaju Qiao ◽  
Mengjiao Zhu ◽  
Yun Fan ◽  
Zhaoxin Lu ◽  
Fengxia Lv ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Small Colony Variants ◽  
Small Colony ◽  
And Control
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