Impact of mitochondrial DNA copy number and displacement loop alterations on polycystic ovary syndrome risk in south Indian women

Mitochondrion ◽  
2019 ◽  
Vol 44 ◽  
pp. 35-40 ◽  
Author(s):  
Tumu Venkat Reddy ◽  
Suresh Govatati ◽  
Mamata Deenadayal ◽  
Shivaji Sisinthy ◽  
Manjula Bhanoori
Keyword(s):  
Mitochondrial Dna ◽  
Polycystic Ovary Syndrome ◽  
Copy Number ◽  
Polycystic Ovary ◽  
Dna Copy Number ◽  
Ovary Syndrome ◽  
Indian Women ◽  
Mitochondrial Dna Copy Number ◽  
South Indian

Mitochondrial DNA copy number in peripheral blood in polycystic ovary syndrome

Metabolism ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 1677-1682 ◽  
Author(s):  
Sang-Hee Lee ◽  
Da-Jung Chung ◽  
Hee-Sun Lee ◽  
Tae-June Kim ◽  
Myung-Hee Kim ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Polycystic Ovary Syndrome ◽  
Peripheral Blood ◽  
Copy Number ◽  
Polycystic Ovary ◽  
Dna Copy Number ◽  
Ovary Syndrome ◽  
Mitochondrial Dna Copy Number

Association of HSD11B1 rs12086634 and HSD11B1 rs846910 gene polymorphisms with polycystic ovary syndrome in South Indian women

2017 ◽  
Vol 38 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Nayana Devang ◽  
Kapaettu Satyamoorthy ◽  
Padmalatha S. Rai ◽  
M. Nandini ◽  
Arindam Basu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Gene Polymorphisms ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Indian Women ◽  
South Indian

scholarly journals An interleukin-6 gene promoter polymorphism is associated with polycystic ovary syndrome in South Indian women

2013 ◽  
Vol 30 (12) ◽  
pp. 1541-1546 ◽  
Author(s):  
Venkat Reddy Tumu ◽  
Suresh Govatati ◽  
Praveen Guruvaiah ◽  
Mamata Deenadayal ◽  
Sisinthy Shivaji ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Interleukin 6 ◽  
Polycystic Ovary ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Ovary Syndrome ◽  
Indian Women ◽  
South Indian ◽  
Gene Promoter Polymorphism

scholarly journals Distinct Genetic Susceptibility Patterns of the Obese and Non-obese South Indian Women with Polycystic Ovary Syndrome

2021 ◽  
Vol 21 (01) ◽  
Author(s):  
B. Mohan Reddy
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Genetic Susceptibility ◽  
Metabolic Pathway ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Indian Women ◽  
Regulatory Variants ◽  
South Indian ◽  
Susceptibility Patterns

The researchers studied association of 92 SNPs of the metabolic and reproductive pathways genes in the obesity related cohorts of obese PCOS cases and non-obese controls, and non-obese PCOS cases and non-obese controls and observed eleven SNPs to be significantly associated (p < 0.05). While eight of those SNPs, five from FTO and one each from MTCH2, DENNDIA and THADA genes, were found to be associated in the first set involving obese PCOS cases, only three SNPs (IRS2-intronic, LOC107984901-intergenic and SUMO1P1-regulatory variants) showed association in the 2nd set involving non-obese cases. The SNPs associated in the two cohorts were distinct and mutually exclusive. However, all the SNPs associated in either obese or non-obese PCOS cohorts were not only risk-prone but also broadly represented a metabolic pathway, involving mostly obesity and T2DM related genes, prompting one to surmise if the recent spurt in PCOS prevalence is not driven by changes in the lifestyles.

Sign in / Sign up

Export Citation Format

Share Document