scholarly journals Altering neuronal circuitry with 4-aminopyridine for visual improvement in leber’s hereditary optic neuropathy (LHON)

Mitochondrion ◽  
2021 ◽  
Author(s):  
Jane W. Chan ◽  
William Sultan ◽  
Rustum Karanjia ◽  
Alfredo A. Sadun
Keyword(s):  
Optic Neuropathy ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Neuronal Circuitry ◽  
Visual Improvement ◽  
Hereditary Optic Neuropathy

scholarly journals Leber’s hereditary optic neuropathy - case report

2012 ◽  
Vol 2 (2) ◽  
pp. 148-152
Author(s):  
Mirjana A. Janicijevic Petrovic ◽  
Tatjana Sarenac Vulovic ◽  
Nenad Petrovic ◽  
Suncica Sreckovic ◽  
Svetlana Paunovic ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Optic Neuropathy ◽  
Visual Loss ◽  
Positive Family History ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Inheritance Pattern ◽  
Visual Improvement ◽  
Hereditary Optic Neuropathy ◽  
Biochemical Abnormalities

Leber’s hereditary optic neuropathy is a neuro-ophthalmological entity characterized by acute or subacute bilateral, not simultaneous visual loss with centro cekal scotoma and occasional further visual improvement. This rare ophthalmological disease can be accompanied with dyschromatopsia. It is associated with a matrilineal inheritance pattern. Its diagnosis used to be solely clini¬cal, aided by imaging and neuro-physiological studies, until the advent of descriptions of mitochondrial biochemical abnormalities and genetic testing. We describe a case of 24 year old male with progressive painless deterioration of visual acuity and positive family history.

Leber's Hereditary Optic Neuropathy: Novel Views and Persisting Challenges

2018 ◽  
Vol 16 (8) ◽  
Author(s):  
Jasna Jancic ◽  
Janko Samardzic ◽  
Stevan Stojanovic ◽  
Amalija Stojanovic ◽  
Ana Marija Milanovic ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

scholarly journals Progress in Gene Therapy to Prevent Retinal Ganglion Cell Loss in Glaucoma and Leber’s Hereditary Optic Neuropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Sara E. Ratican ◽  
Andrew Osborne ◽  
Keith R. Martin
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Optic Nerve ◽  
Genome Editing ◽  
Optic Neuropathy ◽  
Single Gene ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Potential Use ◽  
Hereditary Optic Neuropathy

The eye is at the forefront of the application of gene therapy techniques to medicine. In the United States, a gene therapy treatment for Leber’s congenital amaurosis, a rare inherited retinal disease, recently became the first gene therapy to be approved by the FDA for the treatment of disease caused by mutations in a specific gene. Phase III clinical trials of gene therapy for other single-gene defect diseases of the retina and optic nerve are also currently underway. However, for optic nerve diseases not caused by single-gene defects, gene therapy strategies are likely to focus on slowing or preventing neuronal death through the expression of neuroprotective agents. In addition to these strategies, there has also been recent interest in the potential use of precise genome editing techniques to treat ocular disease. This review focuses on recent developments in gene therapy techniques for the treatment of glaucoma and Leber’s hereditary optic neuropathy (LHON). We discuss recent successes in clinical trials for the treatment of LHON using gene supplementation therapy, promising neuroprotective strategies that have been employed in animal models of glaucoma and the potential use of genome editing techniques in treating optic nerve disease.

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