scholarly journals A study of haematological and bone marrow changes in symptomatic patients with human immune deficiency virus infection with special mention of functional iron deficiency, anaemia of critically ill and haemophagocytic lymphohistiocytosis

2013 ◽  
Vol 69 (4) ◽  
pp. 319-325 ◽  
Author(s):  
Jyoti Kotwal ◽  
Vikram Singh ◽  
Anupam Kotwal ◽  
Vibha Dutta ◽  
Velu Nair
Keyword(s):  
Immune Deficiency ◽  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Human Immune Deficiency Virus ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Functional Iron Deficiency ◽  
Deficiency Anaemia ◽  
Special Mention ◽  
Human Immune

Reticulocyte Parameters in Microcytic Hypochromic Anaemias Using Beckman Coulter DxH800 – A Study from Kerala, India

2021 ◽  
Vol 8 (14) ◽  
pp. 888-892
Author(s):  
Blessy Mary Thomas ◽  
Sheila Das ◽  
Sunil Antony ◽  
Alice David
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Response To Therapy ◽  
Control Group ◽  
Blood Samples ◽  
Deficiency Anaemia ◽  
Chronic Disorder ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia

BACKGROUND Microcytic hypochromic anaemia is commonly due to iron deficiency, anaemia of chronic disorder [ACD] and thalassaemic syndromes. Reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anaemias and monitoring bone marrow response to therapy METHODS All samples were selected from routine blood counts, and sent for investigation of anaemia, over a period of two years. These samples were run on the DxH800 (Beckman Coulter). 385 cases were selected for the study. Blood analysis for all these cases had been requested by general practitioners to investigate anaemia. These blood samples had been collected in ethylenediaminetetraacetic acid (EDTA) anticoagulant vacutainers and processed within 2 hours of collection. Determination of red cell and reticulocyte parameters in all blood samples, was performed using the Beckman Coulter 7-part analyser [Unicell DxH 800]. RESULTS Of the 156 cases of microcytic hypochromic anaemia studied, iron deficiency anaemia (IDA) was present in 91 cases, anaemia of chronic disorder (ACD) in 50 cases, beta thalassemia trait (BTT) in 15 cases. Of the 50 ACD cases, 37 were associated with IDA. The control group comprised of 229 adult medical students (143 women and 103 men) with a median age of 18.84 ± 0.98 years. We also had 4 cases of other haemoglobinopathies, which were microcytic hypochromic, but were not included in our study as the number of cases was too less to be analysed. CONCLUSIONS New reticulocyte parameters are useful for evaluation of iron status and diagnosing iron deficiency anaemias. They also are reliable parameters for recognising subsets of anaemic patients thereby improving the management of anaemia. KEYWORDS Reticulocyte, Microcytic, Hypochromic, Anaemia, Beckman Coulter

Haematology and immunology

2020 ◽  
pp. 635-662
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Nazia Hussain ◽  
Emma Nash ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
General Practice ◽  
Iron Deficiency ◽  
Sedimentation Rate ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

This chapter in the Oxford Handbook of General Practice explores haematology in general practice. It covers full blood count and erythrocyte sedimentation rate. It explores diagnosis and initial investigation of anaemia, iron deficiency anaemia, haemoglobinopathies, bleeding and clotting disorders, and anticoagulation. It examines haematological malignancy, acute leukaemia, chronic leukaemia and myeloproliferation, lymphoma, immune deficiency, and allergy.

Haematology and immunology

2014 ◽  
pp. 659-686
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Matt Burkes
Keyword(s):  
Immune Deficiency ◽  
Iron Deficiency ◽  
Acute Leukaemia ◽  
Blood Test ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

Full blood count and ESR Anaemia: diagnosis and initial investigation Iron deficiency anaemia Other anaemias Haemoglobinopathy Bleeding and clotting disorders Anticoagulation Haematological malignancy Acute leukaemia Chronic leukaemia and myeloproliferation Lymphoma Immune deficiency syndromes Allergies The most commonly requested blood test is the full blood count (FBC). It gives information on:...

scholarly journals Hepcidin and GDF-15 are potential biomarkers of Iron Deficiency Anaemia in Chronic Kidney Disease Patients in South Africa

2020 ◽  
Author(s):  
AISHATU MUHAMMAD NALADO ◽  
Gbenga Olorunfemi ◽  
Therese Dix-Peek ◽  
Caroline Dickens ◽  
Lungile Khambule ◽  
...  
Keyword(s):  
South Africa ◽  
Chronic Kidney Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
P Value ◽  
Academic Hospital ◽  
Functional Iron Deficiency ◽  
Deficiency Anaemia ◽  
Absolute Iron Deficiency ◽  
Potential Biomarkers

Abstract Background Iron deficiency anaemia is a significant cause of morbidity and mortality among chronic kidney disease (CKD) patients. There is a paucity of information on the role of hepcidin and growth differentiation factor-15 (GDF-15) as potential biomarkers of iron deficiency anaemia among non-dialysis CKD patients. This study aimed to determine the utility of hepcidin and GDF-15 as biomarkers of iron deficiency among non-dialysis CKD patients at an academic hospital in Johannesburg, South Africa. Method A cross-sectional study of 312 consecutive consenting non-dialysis CKD patients and 184 controls at Charlotte Maxeke Academic Hospital was conducted from June 2016 to December 2016. Socio-demographic and clinical characteristics were recorded. Plasma hepcidin and GDF-15 were measured using mass spectrometry and ELISA, respectively. Spearman rank correlation, linear and logistic regression and receiver operator curves were utilised to evaluate the predictive and diagnostic/reference values of hepcidin and GDF-15 in absolute and functional iron deficiency anaemia. Results The mean age of participants was 49.7 ±15.8 years, and 50.6% of them were females. The predictive value of diagnosing absolute iron deficiency anaemia among CKD patients using GDF-15 was 74.02% (95% CI: 67.62% - 80.42%) while the predictive value of diagnosing functional iron deficiency anaemia among CKD patients using hepcidin was 70.1% (95% CI: 62.79% - 77.49%).There was a weak negative correlation between hepcidin levels and GFR (r=-0.19, p=0.04) in anaemic CKD patients, and between serum GDF-15 and haemoglobin (r=-0.34, p=0.001). Serum ferritin (β=0.00389, P-value<0.001), was a predictor of log hepcidin. MCHC (β= -0.0220, P-value 0.005) and CKD stage (β=0.4761, P-value <0.001), race (β = 0.3429, P-value = 0.018) were predictors of log GDF-15. Both GDF-15 (adj OR: 1.0003, 95%CI: 1.0001 – 1.0005, P=0.017) and hepcidin (adj OR: 1.003, 95%CI: 1.0004 – 1.0055, P=0.023) were associated with iron deficiency anaemia after multiple linear regression modelling. Subgroup analysis showed that GDF-15 predicted absolute iron deficiency, while hepcidin predicted functional iron deficiency anaemiaConclusion GDF-15 and hepcidin are potential predictors of iron deficiency anaemia among CKD patients.

scholarly journals Estimating prevalence of functional iron deficiency anaemia in advanced cancer

2016 ◽  
Vol 25 (4) ◽  
pp. 1209-1214 ◽  
Author(s):  
Karen Neoh ◽  
Simon Stanworth ◽  
Sant-Rayn Pasricha ◽  
Michael I Bennett
Keyword(s):  
Iron Deficiency ◽  
Advanced Cancer ◽  
Iron Deficiency Anaemia ◽  
Functional Iron Deficiency ◽  
Deficiency Anaemia

scholarly journals Hepcidin and GDF-15 are potential biomarkers of Iron Deficiency Anaemia in Chronic Kidney Disease Patients in South Africa

2019 ◽  
Author(s):  
AISHATU MUHAMMAD NALADO ◽  
Gbenga Olorunfemi ◽  
Therese Dix-Peek ◽  
Caroline Dickens ◽  
Lungile Khambule ◽  
...  
Keyword(s):  
South Africa ◽  
Chronic Kidney Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
P Value ◽  
Academic Hospital ◽  
Functional Iron Deficiency ◽  
Deficiency Anaemia ◽  
And Gender ◽  
Potential Biomarkers

Abstract BackgroundIron deficiency anaemia is a significant cause of morbidity and mortality among chronic kidney disease (CKD) patients. There is a paucity of information on the role of hepcidin and growth differentiation factor-15 (GDF-15) as potential biomarkers of iron deficiency anaemia among non-dialysis CKD patients. This study aimed to determine the utility of hepcidin and GDF-15 as biomarkers of iron deficiency among non-dialysis CKD patients at an academic hospital in Johannesburg, South Africa. MethodA cross-sectional study of 312 consecutive consenting non-dialysis CKD patients and 184 controls at Charlotte Maxeke Academic Hospital was conducted from June 2016 to December 2016. Socio-demographic and clinical characteristics were recorded. Plasma hepcidin and GDF-15 were measured using mass spectrometry and ELISA, respectively. Spearman rank correlation, linear and logistic regression and receiver operator curves were utilised to evaluate the predictive and diagnostic/reference values of hepcidin and GDF-15 in absolute and functional iron deficiency anaemia. ResultsThe mean age of participants was 49.7 ±15.8 years, and 50.6% of them were females. The predictive value of diagnosing iron deficiency anaemia among CKD patients using GDF-15 and hepcidin was high (AUC=0.723 and 0.714, respectively). There was a weak negative correlation between hepcidin levels and GFR (r=-0.19, p=0.04) in anaemic CKD patients, and between serum GDF-15 and haemoglobin (r=-0.34, p=0.001). Serum ferritin (β=0.005, P-value<0.001), MCV (β=0.0276, P-value=0.029) and gender (β=-0.2188, P-value=0.042) were predictors of log hepcidin. Urea (β=0.0062, P-value=0.044), MCHC (β= -0.0816, P-value<0.001) and gender (β=-0.0755, P-value=0.001) were predictors of logGDF-15. Both GDF-15 (P=0.028) and hepcidin (P=0.049) were associated with iron deficiency anaemia. Subgroup analysis showed that GDF-15 predicted absolute iron deficiency, while hepcidin predicted functional iron deficiency anaemiaConclusionGDF-15 and hepcidin are potential predictors of iron deficiency anaemia among CKD patients.

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