Haematology and immunology

2014 ◽  
pp. 659-686
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Matt Burkes
Keyword(s):  
Immune Deficiency ◽  
Iron Deficiency ◽  
Acute Leukaemia ◽  
Blood Test ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

Full blood count and ESR Anaemia: diagnosis and initial investigation Iron deficiency anaemia Other anaemias Haemoglobinopathy Bleeding and clotting disorders Anticoagulation Haematological malignancy Acute leukaemia Chronic leukaemia and myeloproliferation Lymphoma Immune deficiency syndromes Allergies The most commonly requested blood test is the full blood count (FBC). It gives information on:...

Haematology and immunology

2020 ◽  
pp. 635-662
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Nazia Hussain ◽  
Emma Nash ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
General Practice ◽  
Iron Deficiency ◽  
Sedimentation Rate ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

This chapter in the Oxford Handbook of General Practice explores haematology in general practice. It covers full blood count and erythrocyte sedimentation rate. It explores diagnosis and initial investigation of anaemia, iron deficiency anaemia, haemoglobinopathies, bleeding and clotting disorders, and anticoagulation. It examines haematological malignancy, acute leukaemia, chronic leukaemia and myeloproliferation, lymphoma, immune deficiency, and allergy.

scholarly journals The Diagnostic Patterns of Iron Deficiency and Iron Deficiency Anaemia in Children of 6 to 59 Months in Cameroon

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
S. D. Agokeng ◽  
A. L. Njunda ◽  
C. T. Tayou ◽  
C. N. J. Assob
Keyword(s):  
Iron Deficiency ◽  
Mean Corpuscular Volume ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Ferritin Level ◽  
Full Blood Count ◽  
Corpuscular Volume ◽  
Deficiency Anaemia ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin

A Cross sectional multicentre study was carried out to determine the prevalence of Iron deficiency (ID) and Iron deficiency anaemia (IDA) in children using Ferritin and full blood count. Full blood count was done with Mindray Bc-2800 and Ferritin test with Enzyme Linked Immuno-Sorbent Assay. Authorization was granted by Cameroonian national Ethical Committee. Data were analysed using Statistical Package of Social Sciences 21.0 significant results were considered for P< 0.05. ID varied from 4.2% to 9.6% for cut-offs of 30 and 50μg/L. IDA ranged from 4.2 to 8.5% at these 2 cut-offs. Considering red cells indices, Mean Corpuscular Volume and Mean Corpuscular Haemoglobin blood count currently used should be interpreted cautiously as only Mean Corpuscular Volume and Mean Corpuscular Haemoglobin corroborate with a Ferritin level lower than 30 μg/L.

scholarly journals Prevalence of Iron Deficiency, Iron Deficiency Anaemia and General Anaemia in Male Gambian Blood Donors Residing in Greater Banjul Region

2021 ◽  
Author(s):  
Mustapha Dibbasey ◽  
Bolarinde Lawal ◽  
Solomon Umukoro ◽  
Peter Mitchel
Keyword(s):  
Iron Deficiency ◽  
Blood Donor ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Blood Donors ◽  
Blood Donation ◽  
Full Blood Count ◽  
Serum Samples ◽  
Deficiency Anaemia ◽  
Donor Population

AbstractObjectiveThe objective of this study is to determine the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) as well as general anaemia in male blood donors and their association with ageing process.Methodology and ResultsA total of two hundred and one (201) serum samples were analysed for ferritin in male Gambian blood donors. The ferritin measurement was achieved with COBAS® INTEGRA 400 plus. At the same time, haemoglobin values were retrospectively obtained from the archived haematological full blood count result in the GARIS database. IDA was defined as (Haemoglobin <13.0g/dL+ Ferritin<15ng/ml) whilst ID was defined as (Haemoglobin ≥13.0g/dL+ Ferritin<15ng/ml) and general anaemia was defined as haemoglobin <13.0g/dL in males. The prevalence of anaemia (20%, n=41), ID (22%, n=44) and IDA (10%, n=21), were recorded in male donors. The results show no relationship between ferritin and haemoglobin among the blood donors (collection coefficient (r) = 0.04). Besides, no linear association of having anaemia and ID with ageing was reported among the blood donor population.Conclusion and potential application of findingsID and IDA as well as general anaemia are highly prevalent among blood donors in the Gambia. Besides, no predisposition to ID and anaemia was observed in term of age, thus all blood donors from 18-60 should be considered for blood donation without any age preference.

scholarly journals TP7.2.11 Hypochromia is an early marker of iron deficiency anaemia

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Inae Hwang ◽  
Jeremy Cheong ◽  
Sriram Subramonia
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Gastrointestinal Cancers ◽  
Deficiency Anaemia ◽  
Referral Criteria ◽  
Laboratory Test Results ◽  
Red Cell Indices ◽  
Mean Corpuscular Haemoglobin

Abstract Aim Microcytosis in iron deficiency anaemia triggers an urgent referral for investigation of suspected gastrointestinal cancers. This study evaluated whether the inclusion of hypochromia as a marker for iron deficiency would lead to earlier referrals. Method Consecutive patients referred from primary care under the 2-week wait suspected gastrointestinal cancer pathway with unexplained iron deficiency anaemia between October 2019 and October 2020 were included. Results of red cell indices were obtained from an electronic platform for accessing laboratory test results(Sunquest ICE™, Version 5.4, Sunquest Information Systems). Mean corpuscular haemoglobin (MCH) of 27-32pg and mean corpuscular volume (MCV) of 80-102fL were considered normal. Results Seventy nine patients (32 men, 47 women) were included. Median (IQR) age was 73 (62-80) years. 67% (53/79) had a low MCH and 43% (34/79) had a low MCV at the time of referral. In the preceding months of referral (median [IQR] 4.3 [1.8-7.9] months) 64 patients had a full blood count performed of which 55% (35/64) had a low MCH and 20% (13/64) had a low MCV. The earliest available full blood count prior to referral (43 patients, median (IQR) of 16.5 (12-37) months) showed that 86% (37/43) had a low MCH compared to 33% (14/43) with a low MCV. A fall in MCH always preceded a fall in MCV at all the three time points analysed. Conclusion The inclusion of hypochromia as a marker of iron deficiency in the referral criteria for suspected gastrointestinal cancers would trigger significantly earlier referrals.

scholarly journals Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Orouba Almilaji ◽  
Sally D. Parry ◽  
Sharon Docherty ◽  
Jonathon Snook
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Early Stage ◽  
Deficiency Anaemia ◽  
Logistic Regression Models ◽  
Parametric Survival Model ◽  
Bowel Cancer Screening ◽  
The Uk

AbstractIron deficiency anaemia (IDA) is common in colorectal cancer (CRC), especially, in right-sided CRC which is known to have an overall worse prognosis. The associations between diagnostic pathway (Bowel Cancer Screening Programme (BCSP), IDA, symptomatic) and tumour side/stage was assessed using logistic regression models in 1138 CRC cases presenting during 2010–2016 at a single secondary-care centre in the UK. In the IDA sub-group, the relationship between CRC stage and the event of having a blood count prior to CRC diagnosis was examined using Bayesian parametric survival model. IDA was found as the only significant predictor of right-sided CRC (OR 10.61, 95% CI 7.02–16.52). Early-stage CRC was associated with both the IDA (OR 1.65, 95% CI 1.18–2.29) and BCSP pathway (OR 2.42, 95% CI 1.75–3.37). At any age, the risk of detecting CRC at late-stage was higher in those without a previous blood count check (hazard ratio 1.53, 95% credibility interval 1.08–2.14). The findings of this retrospective observational study suggest a benefit from diagnosing CRC through the detection of IDA, and warrant further research into the prognosis benefit of systematic approach to blood count monitoring of the at-risk population.

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