Proline cis-trans Isomerization Controls Autoinhibition of a Signaling Protein

Molecular Cell ◽

10.1016/j.molcel.2007.01.004 ◽

2007 ◽

Vol 25 (3) ◽

pp. 413-426 ◽

Author(s):

Paramita Sarkar ◽

Charles Reichman ◽

Tamjeed Saleh ◽

Raymond B. Birge ◽

Charalampos G. Kalodimos

Keyword(s):

Signaling Protein ◽

Trans Isomerization

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Faculty Opinions recommendation of Proline cis-trans isomerization controls autoinhibition of a signaling protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1104393.560416 ◽

2008 ◽

Author(s):

Dorothee Kern

Keyword(s):

Signaling Protein ◽

Trans Isomerization

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Faculty Opinions recommendation of RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1013099.189002 ◽

2003 ◽

Author(s):

Paul Anderson

Keyword(s):

Mast Cell ◽

Cell Development ◽

Guanine Nucleotide ◽

Cell Leukemia ◽

Binding Motifs ◽

Signaling Protein ◽

Mast Cell Leukemia ◽

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Faculty Opinions recommendation of Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029080.343640 ◽

2005 ◽

Author(s):

Thomas Kodadek

Keyword(s):

Ion Channel ◽

Trans Isomerization

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Faculty Opinions recommendation of Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1027701.343456 ◽

2005 ◽

Author(s):

Jenny Ting

Keyword(s):

Antiviral Signaling ◽

Signaling Protein ◽

Mitochondrial Antiviral Signaling ◽

Nf Kappab ◽

Identification And Characterization ◽

Mitochondrial Antiviral Signaling Protein

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Faculty Opinions recommendation of Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029549.357553 ◽

2006 ◽

Author(s):

Rino Rappuoli

Keyword(s):

Innate Immunity ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Antiviral Signaling ◽

Signaling Protein ◽

Mitochondrial Antiviral Signaling ◽

Mitochondrial Antiviral Signaling Protein

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Faculty Opinions recommendation of The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1122799.604724 ◽

2009 ◽

Author(s):

Avinash Bhandoola

Keyword(s):

Beta Catenin ◽

Hematopoietic Progenitors ◽

Signaling Protein

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Faculty Opinions recommendation of Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1165970.626844 ◽

2009 ◽

Author(s):

Mark Johnson ◽

Cielo Barragan

Keyword(s):

Wnt Signaling ◽

Signaling Pathway ◽

Wnt Signaling Pathway ◽

Signaling Protein

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Faculty Opinions recommendation of Transient non-native hydrogen bonds promote activation of a signaling protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1366960.838058 ◽

2009 ◽

Author(s):

Matthias Buck

Keyword(s):

Hydrogen Bonds ◽

Signaling Protein

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Faculty Opinions recommendation of Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14221957.15735057 ◽

2012 ◽

Author(s):

Ganes Sen ◽

Saurabh Chattopadhyay

Keyword(s):

Immune Response ◽

Experimental Colitis ◽

Commensal Bacteria ◽

Antiviral Signaling ◽

Signaling Protein ◽

Mitochondrial Antiviral Signaling ◽

Mitochondrial Antiviral Signaling Protein

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Faculty Opinions recommendation of Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717965100.793466266 ◽

2012 ◽

Author(s):

Nikolay Dokholyan ◽

Pradeep Kota

Keyword(s):

Real Time ◽

Protein Function ◽

Time Resolved ◽

Signaling Protein

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